Peripheral non-enzymatic antioxidants in patients with schizophrenia: a case-control study
Abstract Background Recent studies show that oxidative stress is associated with the pathogenesis of schizophrenia. There are two major types of antioxidant systems in vivo, namely enzymatic antioxidants and non-enzymatic antioxidants. This study investigated differences of non-enzymatic antioxidant...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2020-05-01
|
| Series: | BMC Psychiatry |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12888-020-02635-8 |
| _version_ | 1818490473768026112 |
|---|---|
| author | Zhe Lu Tianyang Wen Yingtan Wang Weijing Kan Guanglei Xun |
| author_facet | Zhe Lu Tianyang Wen Yingtan Wang Weijing Kan Guanglei Xun |
| author_sort | Zhe Lu |
| collection | DOAJ |
| description | Abstract Background Recent studies show that oxidative stress is associated with the pathogenesis of schizophrenia. There are two major types of antioxidant systems in vivo, namely enzymatic antioxidants and non-enzymatic antioxidants. This study investigated differences of non-enzymatic antioxidants between schizophrenia patients and healthy controls. Methods Peripheral UA, ALB, and TBIL of 107 schizophrenic patients in the acute stage and 101 in the remission stage were measured respectively, so were 273 healthy controls. Results The levels of UA (P = 0.020) and TBIL (P < 0.001) of schizophrenic patients in the acute stage were higher than those of healthy controls, while the level of ALB (P < 0.001) was lower. Similar results were detected form schizophrenic patients in the remission stage. Schizophrenic patients in the acute stage were divided into antipsychotics-use subgroup (n = 56) and antipsychotics-naïve/free subgroup (n = 51). The level of UA (P = 0.001) in the antipsychotics-use subgroup was higher than that in the antipsychotics-naïve/free subgroup, while the level of TBIL (P = 0.002) was lower than that in the antipsychotics-naïve/free subgroup. Seventy-seven schizophrenic patients in the acute stage were followed up, and there was no significant difference in the level of UA before and after treatment, but levels of ALB (P < 0.001) and TBIL (P < 0.001) decreased significantly after the treatment. Conclusion This study demonstrated that the dysfunction of the peripheral non-enzymatic anti-oxidation system might be involved in the pathogenesis of schizophrenia. |
| first_indexed | 2024-12-10T17:17:31Z |
| format | Article |
| id | doaj.art-402fb184253a4185ace1e6ab95ac8a52 |
| institution | Directory Open Access Journal |
| issn | 1471-244X |
| language | English |
| last_indexed | 2024-12-10T17:17:31Z |
| publishDate | 2020-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Psychiatry |
| spelling | doaj.art-402fb184253a4185ace1e6ab95ac8a522022-12-22T01:40:05ZengBMCBMC Psychiatry1471-244X2020-05-012011910.1186/s12888-020-02635-8Peripheral non-enzymatic antioxidants in patients with schizophrenia: a case-control studyZhe Lu0Tianyang Wen1Yingtan Wang2Weijing Kan3Guanglei Xun4Cheeloo College of Medicine, Shandong UniversityShandong Mental Health CenterDepartment of Mental Health, Jining Medical UniversityBeijing An Ding Hospital, Capital Medical University, China National Clinical Research Center for Mental DisordersShandong Mental Health CenterAbstract Background Recent studies show that oxidative stress is associated with the pathogenesis of schizophrenia. There are two major types of antioxidant systems in vivo, namely enzymatic antioxidants and non-enzymatic antioxidants. This study investigated differences of non-enzymatic antioxidants between schizophrenia patients and healthy controls. Methods Peripheral UA, ALB, and TBIL of 107 schizophrenic patients in the acute stage and 101 in the remission stage were measured respectively, so were 273 healthy controls. Results The levels of UA (P = 0.020) and TBIL (P < 0.001) of schizophrenic patients in the acute stage were higher than those of healthy controls, while the level of ALB (P < 0.001) was lower. Similar results were detected form schizophrenic patients in the remission stage. Schizophrenic patients in the acute stage were divided into antipsychotics-use subgroup (n = 56) and antipsychotics-naïve/free subgroup (n = 51). The level of UA (P = 0.001) in the antipsychotics-use subgroup was higher than that in the antipsychotics-naïve/free subgroup, while the level of TBIL (P = 0.002) was lower than that in the antipsychotics-naïve/free subgroup. Seventy-seven schizophrenic patients in the acute stage were followed up, and there was no significant difference in the level of UA before and after treatment, but levels of ALB (P < 0.001) and TBIL (P < 0.001) decreased significantly after the treatment. Conclusion This study demonstrated that the dysfunction of the peripheral non-enzymatic anti-oxidation system might be involved in the pathogenesis of schizophrenia.http://link.springer.com/article/10.1186/s12888-020-02635-8SchizophreniaUric acidAlbuminTotal bilirubin |
| spellingShingle | Zhe Lu Tianyang Wen Yingtan Wang Weijing Kan Guanglei Xun Peripheral non-enzymatic antioxidants in patients with schizophrenia: a case-control study BMC Psychiatry Schizophrenia Uric acid Albumin Total bilirubin |
| title | Peripheral non-enzymatic antioxidants in patients with schizophrenia: a case-control study |
| title_full | Peripheral non-enzymatic antioxidants in patients with schizophrenia: a case-control study |
| title_fullStr | Peripheral non-enzymatic antioxidants in patients with schizophrenia: a case-control study |
| title_full_unstemmed | Peripheral non-enzymatic antioxidants in patients with schizophrenia: a case-control study |
| title_short | Peripheral non-enzymatic antioxidants in patients with schizophrenia: a case-control study |
| title_sort | peripheral non enzymatic antioxidants in patients with schizophrenia a case control study |
| topic | Schizophrenia Uric acid Albumin Total bilirubin |
| url | http://link.springer.com/article/10.1186/s12888-020-02635-8 |
| work_keys_str_mv | AT zhelu peripheralnonenzymaticantioxidantsinpatientswithschizophreniaacasecontrolstudy AT tianyangwen peripheralnonenzymaticantioxidantsinpatientswithschizophreniaacasecontrolstudy AT yingtanwang peripheralnonenzymaticantioxidantsinpatientswithschizophreniaacasecontrolstudy AT weijingkan peripheralnonenzymaticantioxidantsinpatientswithschizophreniaacasecontrolstudy AT guangleixun peripheralnonenzymaticantioxidantsinpatientswithschizophreniaacasecontrolstudy |