A case of Podocytic Infolding Glomerulopathy with SLE and literature review
Abstract Background Podocytic infolding glomerulopathy (PIG) is a rare pathological change which was characterized by the microspheres or microtubular structures in the thickened glomerular basement membrane (GBM). Only a few dozen cases have been reported worldwide so far. Here we present a case of...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-12-01
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| Series: | BMC Nephrology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12882-021-02615-4 |
| _version_ | 1818701125092638720 |
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| author | Xi Liu Jieli Huang Kun Zhang Yangyang Niu Yuting Liu Chunli Cui Chen Yu |
| author_facet | Xi Liu Jieli Huang Kun Zhang Yangyang Niu Yuting Liu Chunli Cui Chen Yu |
| author_sort | Xi Liu |
| collection | DOAJ |
| description | Abstract Background Podocytic infolding glomerulopathy (PIG) is a rare pathological change which was characterized by the microspheres or microtubular structures in the thickened glomerular basement membrane (GBM). Only a few dozen cases have been reported worldwide so far. Here we present a case of PIG with systemic lupus erythematosus. Case presentation A 61-year-old Chinese female was diagnosed with systemic lupus erythematosus with clinical manifestations of proteinuria, pleural effusion, seroperitoneum, anemia, leukopenia, thrombocytopenia, antinuclear antibody positive, and hypocomplementemia. She also had benign ovarian tumor and Epstein-Barr virus infection. Renal biopsy immunofluorescent staining showed IgM and C3 were granularly deposited along the capillary wall instead of typical “full house” features. Electron microscopy showed lots of microspheres structures were seen in the thickened GBM. Conclusion We present a case of PIG in a patient with systemic lupus erythematosus. The mechanisms of PIG are unknown, but may be associated with connective tissue disease and podocyte injury. |
| first_indexed | 2024-12-17T15:15:52Z |
| format | Article |
| id | doaj.art-402fbb90f8b64d58893a8ff49de570f2 |
| institution | Directory Open Access Journal |
| issn | 1471-2369 |
| language | English |
| last_indexed | 2024-12-17T15:15:52Z |
| publishDate | 2021-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Nephrology |
| spelling | doaj.art-402fbb90f8b64d58893a8ff49de570f22022-12-21T21:43:31ZengBMCBMC Nephrology1471-23692021-12-012211410.1186/s12882-021-02615-4A case of Podocytic Infolding Glomerulopathy with SLE and literature reviewXi Liu0Jieli Huang1Kun Zhang2Yangyang Niu3Yuting Liu4Chunli Cui5Chen Yu6The Department of Nephrology, Tongji Hospital, Tongji University School of MedicineThe Department of Nephrology, Tongji Hospital, Tongji University School of MedicineThe Department of Nephrology, Tongji Hospital, Tongji University School of MedicineThe Department of Nephrology, Tongji Hospital, Tongji University School of MedicineThe Department of Nephrology, Tongji Hospital, Tongji University School of MedicineThe Department of Nephrology, Tongji Hospital, Tongji University School of MedicineThe Department of Nephrology, Tongji Hospital, Tongji University School of MedicineAbstract Background Podocytic infolding glomerulopathy (PIG) is a rare pathological change which was characterized by the microspheres or microtubular structures in the thickened glomerular basement membrane (GBM). Only a few dozen cases have been reported worldwide so far. Here we present a case of PIG with systemic lupus erythematosus. Case presentation A 61-year-old Chinese female was diagnosed with systemic lupus erythematosus with clinical manifestations of proteinuria, pleural effusion, seroperitoneum, anemia, leukopenia, thrombocytopenia, antinuclear antibody positive, and hypocomplementemia. She also had benign ovarian tumor and Epstein-Barr virus infection. Renal biopsy immunofluorescent staining showed IgM and C3 were granularly deposited along the capillary wall instead of typical “full house” features. Electron microscopy showed lots of microspheres structures were seen in the thickened GBM. Conclusion We present a case of PIG in a patient with systemic lupus erythematosus. The mechanisms of PIG are unknown, but may be associated with connective tissue disease and podocyte injury.https://doi.org/10.1186/s12882-021-02615-4Podocytic infolding glomerulopathyPodocytes,Systemic lupus erythematosusEB virusOvarian tumor |
| spellingShingle | Xi Liu Jieli Huang Kun Zhang Yangyang Niu Yuting Liu Chunli Cui Chen Yu A case of Podocytic Infolding Glomerulopathy with SLE and literature review BMC Nephrology Podocytic infolding glomerulopathy Podocytes,Systemic lupus erythematosus EB virus Ovarian tumor |
| title | A case of Podocytic Infolding Glomerulopathy with SLE and literature review |
| title_full | A case of Podocytic Infolding Glomerulopathy with SLE and literature review |
| title_fullStr | A case of Podocytic Infolding Glomerulopathy with SLE and literature review |
| title_full_unstemmed | A case of Podocytic Infolding Glomerulopathy with SLE and literature review |
| title_short | A case of Podocytic Infolding Glomerulopathy with SLE and literature review |
| title_sort | case of podocytic infolding glomerulopathy with sle and literature review |
| topic | Podocytic infolding glomerulopathy Podocytes,Systemic lupus erythematosus EB virus Ovarian tumor |
| url | https://doi.org/10.1186/s12882-021-02615-4 |
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