The relative contributions of myocardial perfusion, blood volume and extracellular volume to native T1 and native T2 at rest and during adenosine stress in normal physiology
Abstract Background Both ischemic and non-ischemic heart disease can cause disturbances in the myocardial blood volume (MBV), myocardial perfusion and the myocardial extracellular volume fraction (ECV). Recent studies suggest that native myocardial T1 mapping can detect changes in MBV during adenosi...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2019-11-01
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| Series: | Journal of Cardiovascular Magnetic Resonance |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12968-019-0585-9 |
| _version_ | 1797204176957079552 |
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| author | Jannike Nickander Raquel Themudo Simon Thalén Andreas Sigfridsson Hui Xue Peter Kellman Martin Ugander |
| author_facet | Jannike Nickander Raquel Themudo Simon Thalén Andreas Sigfridsson Hui Xue Peter Kellman Martin Ugander |
| author_sort | Jannike Nickander |
| collection | DOAJ |
| description | Abstract Background Both ischemic and non-ischemic heart disease can cause disturbances in the myocardial blood volume (MBV), myocardial perfusion and the myocardial extracellular volume fraction (ECV). Recent studies suggest that native myocardial T1 mapping can detect changes in MBV during adenosine stress without the use of contrast agents. Furthermore, native T2 mapping could also potentially be used to quantify changes in myocardial perfusion and/or MBV. Therefore, the aim of this study was to explore the relative contributions of myocardial perfusion, MBV and ECV to native T1 and native T2 at rest and during adenosine stress in normal physiology. Methods Healthy subjects (n = 41, 26 ± 5 years, 51% females) underwent 1.5 T cardiovascular magnetic resonance (CMR) scanning. Quantitative myocardial perfusion [ml/min/g] and MBV [%] maps were computed from first pass perfusion imaging at adenosine stress (140 microg/kg/min infusion) and rest following an intravenous contrast bolus (0.05 mmol/kg, gadobutrol). Native T1 and T2 maps were acquired before and during adenosine stress. T1 maps at rest and stress were also acquired following a 0.2 mmol/kg cumulative intravenous contrast dose, rendering rest and stress ECV maps [%]. Myocardial T1, T2, perfusion, MBV and ECV values were measured by delineating a region of interest in the midmural third of the myocardium. Results During adenosine stress, there was an increase in myocardial native T1, native T2, perfusion, MBV, and ECV (p ≤ 0.001 for all). Myocardial perfusion, MBV and ECV all correlated with both native T1 and native T2, respectively (R2 = 0.35 to 0.61, p < 0.001 for all). Multivariate linear regression revealed that ECV and perfusion together best explained the change in native T2 (ECV beta 0.21, p = 0.02, perfusion beta 0.66, p < 0.001, model R2 = 0.64, p < 0.001), and native T1 (ECV beta 0.50, p < 0.001, perfusion beta 0.43, p < 0.001, model R2 = 0.69, p < 0.001). Conclusions Myocardial native T1, native T2, perfusion, MBV, and ECV all increase during adenosine stress. Changes in myocardial native T1 and T2 during adenosine stress in normal physiology can largely be explained by the combined changes in myocardial perfusion and ECV. Trial registration Clinicaltrials.gov identifier NCT02723747. Registered March 16, 2016. |
| first_indexed | 2024-04-24T08:31:04Z |
| format | Article |
| id | doaj.art-40301a291ec54d55b57168e509a8de11 |
| institution | Directory Open Access Journal |
| issn | 1532-429X |
| language | English |
| last_indexed | 2024-04-24T08:31:04Z |
| publishDate | 2019-11-01 |
| publisher | Elsevier |
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| series | Journal of Cardiovascular Magnetic Resonance |
| spelling | doaj.art-40301a291ec54d55b57168e509a8de112024-04-16T19:36:39ZengElsevierJournal of Cardiovascular Magnetic Resonance1532-429X2019-11-0121111010.1186/s12968-019-0585-9The relative contributions of myocardial perfusion, blood volume and extracellular volume to native T1 and native T2 at rest and during adenosine stress in normal physiologyJannike Nickander0Raquel Themudo1Simon Thalén2Andreas Sigfridsson3Hui Xue4Peter Kellman5Martin Ugander6Department of Clinical Physiology, Karolinska University Hospital and Karolinska InstitutetDepartment of Clinical Physiology, Karolinska University Hospital and Karolinska InstitutetDepartment of Clinical Physiology, Karolinska University Hospital and Karolinska InstitutetDepartment of Clinical Physiology, Karolinska University Hospital and Karolinska InstitutetNational Heart, Lung, and Blood Institute, National Institutes of HealthNational Heart, Lung, and Blood Institute, National Institutes of HealthDepartment of Clinical Physiology, Karolinska University Hospital and Karolinska InstitutetAbstract Background Both ischemic and non-ischemic heart disease can cause disturbances in the myocardial blood volume (MBV), myocardial perfusion and the myocardial extracellular volume fraction (ECV). Recent studies suggest that native myocardial T1 mapping can detect changes in MBV during adenosine stress without the use of contrast agents. Furthermore, native T2 mapping could also potentially be used to quantify changes in myocardial perfusion and/or MBV. Therefore, the aim of this study was to explore the relative contributions of myocardial perfusion, MBV and ECV to native T1 and native T2 at rest and during adenosine stress in normal physiology. Methods Healthy subjects (n = 41, 26 ± 5 years, 51% females) underwent 1.5 T cardiovascular magnetic resonance (CMR) scanning. Quantitative myocardial perfusion [ml/min/g] and MBV [%] maps were computed from first pass perfusion imaging at adenosine stress (140 microg/kg/min infusion) and rest following an intravenous contrast bolus (0.05 mmol/kg, gadobutrol). Native T1 and T2 maps were acquired before and during adenosine stress. T1 maps at rest and stress were also acquired following a 0.2 mmol/kg cumulative intravenous contrast dose, rendering rest and stress ECV maps [%]. Myocardial T1, T2, perfusion, MBV and ECV values were measured by delineating a region of interest in the midmural third of the myocardium. Results During adenosine stress, there was an increase in myocardial native T1, native T2, perfusion, MBV, and ECV (p ≤ 0.001 for all). Myocardial perfusion, MBV and ECV all correlated with both native T1 and native T2, respectively (R2 = 0.35 to 0.61, p < 0.001 for all). Multivariate linear regression revealed that ECV and perfusion together best explained the change in native T2 (ECV beta 0.21, p = 0.02, perfusion beta 0.66, p < 0.001, model R2 = 0.64, p < 0.001), and native T1 (ECV beta 0.50, p < 0.001, perfusion beta 0.43, p < 0.001, model R2 = 0.69, p < 0.001). Conclusions Myocardial native T1, native T2, perfusion, MBV, and ECV all increase during adenosine stress. Changes in myocardial native T1 and T2 during adenosine stress in normal physiology can largely be explained by the combined changes in myocardial perfusion and ECV. Trial registration Clinicaltrials.gov identifier NCT02723747. Registered March 16, 2016.http://link.springer.com/article/10.1186/s12968-019-0585-9Native T1Native T2Stress cardiovascular magnetic resonanceQuantitative perfusionMyocardial blood volumeExtracellular volume |
| spellingShingle | Jannike Nickander Raquel Themudo Simon Thalén Andreas Sigfridsson Hui Xue Peter Kellman Martin Ugander The relative contributions of myocardial perfusion, blood volume and extracellular volume to native T1 and native T2 at rest and during adenosine stress in normal physiology Journal of Cardiovascular Magnetic Resonance Native T1 Native T2 Stress cardiovascular magnetic resonance Quantitative perfusion Myocardial blood volume Extracellular volume |
| title | The relative contributions of myocardial perfusion, blood volume and extracellular volume to native T1 and native T2 at rest and during adenosine stress in normal physiology |
| title_full | The relative contributions of myocardial perfusion, blood volume and extracellular volume to native T1 and native T2 at rest and during adenosine stress in normal physiology |
| title_fullStr | The relative contributions of myocardial perfusion, blood volume and extracellular volume to native T1 and native T2 at rest and during adenosine stress in normal physiology |
| title_full_unstemmed | The relative contributions of myocardial perfusion, blood volume and extracellular volume to native T1 and native T2 at rest and during adenosine stress in normal physiology |
| title_short | The relative contributions of myocardial perfusion, blood volume and extracellular volume to native T1 and native T2 at rest and during adenosine stress in normal physiology |
| title_sort | relative contributions of myocardial perfusion blood volume and extracellular volume to native t1 and native t2 at rest and during adenosine stress in normal physiology |
| topic | Native T1 Native T2 Stress cardiovascular magnetic resonance Quantitative perfusion Myocardial blood volume Extracellular volume |
| url | http://link.springer.com/article/10.1186/s12968-019-0585-9 |
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