Efficacy of Synthetic Peptide Corresponding to the ACTH-Like Sequence of Human Immunoglobulin G1 in Experimental Autoimmune Encephalomyelitis
Peptide immunocortin sequence corresponds to the amino acid residues 11–20 of the variable part of human immunoglobulin G1 (IgG1) heavy chain. Since immunocortin was shown previously to inhibit phagocytosis in peritoneal macrophages and ConA-induced T-lymphocytes proliferation in culture, we suggest...
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| Format: | Article |
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Frontiers Media S.A.
2018-02-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fphar.2018.00113/full |
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| author | Valery I. Turobov Alexey V. Danilkovich Alexei B. Shevelev Yulia K. Biryukova Natalia V. Pozdniakova Viatcheslav N. Azev Arkady N. Murashev Arkady N. Murashev Valery M. Lipkin Igor P. Udovichenko |
| author_facet | Valery I. Turobov Alexey V. Danilkovich Alexei B. Shevelev Yulia K. Biryukova Natalia V. Pozdniakova Viatcheslav N. Azev Arkady N. Murashev Arkady N. Murashev Valery M. Lipkin Igor P. Udovichenko |
| author_sort | Valery I. Turobov |
| collection | DOAJ |
| description | Peptide immunocortin sequence corresponds to the amino acid residues 11–20 of the variable part of human immunoglobulin G1 (IgG1) heavy chain. Since immunocortin was shown previously to inhibit phagocytosis in peritoneal macrophages and ConA-induced T-lymphocytes proliferation in culture, we suggested that immunocortin administering may be of use for patients with self-immune syndrome. Immunocortin in concentration 10 μM inhibited proliferation of both antigen (myelin)-induced and ConA-induced LN lymphocytes isolated from the lymph nodes of Dark Agouti (DA) rats immunized with chorda shear. The biological trials of the synthetic immunocortin were carried out on the DA rats with induced experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis. These in vivo experiments have shown that intraperitoneal injections of immunocortin in a daily dosage 100 μg per animal reduced symptoms of EAE in DA rats. |
| first_indexed | 2024-04-13T01:53:41Z |
| format | Article |
| id | doaj.art-40304a9d049f45a685ae5a9b5e40ce7e |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-13T01:53:41Z |
| publishDate | 2018-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-40304a9d049f45a685ae5a9b5e40ce7e2022-12-22T03:07:49ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122018-02-01910.3389/fphar.2018.00113326394Efficacy of Synthetic Peptide Corresponding to the ACTH-Like Sequence of Human Immunoglobulin G1 in Experimental Autoimmune EncephalomyelitisValery I. Turobov0Alexey V. Danilkovich1Alexei B. Shevelev2Yulia K. Biryukova3Natalia V. Pozdniakova4Viatcheslav N. Azev5Arkady N. Murashev6Arkady N. Murashev7Valery M. Lipkin8Igor P. Udovichenko9Branch of Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, RussiaBranch of Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, RussiaEmanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, RussiaEmanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, RussiaN. N. Blokhin Cancer Research Center, Moscow, RussiaBranch of Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, RussiaBranch of Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, RussiaPushchino Research Center, Russian Academy of Sciences, Pushchino, RussiaBranch of Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, RussiaBranch of Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, RussiaPeptide immunocortin sequence corresponds to the amino acid residues 11–20 of the variable part of human immunoglobulin G1 (IgG1) heavy chain. Since immunocortin was shown previously to inhibit phagocytosis in peritoneal macrophages and ConA-induced T-lymphocytes proliferation in culture, we suggested that immunocortin administering may be of use for patients with self-immune syndrome. Immunocortin in concentration 10 μM inhibited proliferation of both antigen (myelin)-induced and ConA-induced LN lymphocytes isolated from the lymph nodes of Dark Agouti (DA) rats immunized with chorda shear. The biological trials of the synthetic immunocortin were carried out on the DA rats with induced experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis. These in vivo experiments have shown that intraperitoneal injections of immunocortin in a daily dosage 100 μg per animal reduced symptoms of EAE in DA rats.http://journal.frontiersin.org/article/10.3389/fphar.2018.00113/fullmultiple sclerosispeptide drugsimmunosuppressorsimmunocortinanimal model |
| spellingShingle | Valery I. Turobov Alexey V. Danilkovich Alexei B. Shevelev Yulia K. Biryukova Natalia V. Pozdniakova Viatcheslav N. Azev Arkady N. Murashev Arkady N. Murashev Valery M. Lipkin Igor P. Udovichenko Efficacy of Synthetic Peptide Corresponding to the ACTH-Like Sequence of Human Immunoglobulin G1 in Experimental Autoimmune Encephalomyelitis Frontiers in Pharmacology multiple sclerosis peptide drugs immunosuppressors immunocortin animal model |
| title | Efficacy of Synthetic Peptide Corresponding to the ACTH-Like Sequence of Human Immunoglobulin G1 in Experimental Autoimmune Encephalomyelitis |
| title_full | Efficacy of Synthetic Peptide Corresponding to the ACTH-Like Sequence of Human Immunoglobulin G1 in Experimental Autoimmune Encephalomyelitis |
| title_fullStr | Efficacy of Synthetic Peptide Corresponding to the ACTH-Like Sequence of Human Immunoglobulin G1 in Experimental Autoimmune Encephalomyelitis |
| title_full_unstemmed | Efficacy of Synthetic Peptide Corresponding to the ACTH-Like Sequence of Human Immunoglobulin G1 in Experimental Autoimmune Encephalomyelitis |
| title_short | Efficacy of Synthetic Peptide Corresponding to the ACTH-Like Sequence of Human Immunoglobulin G1 in Experimental Autoimmune Encephalomyelitis |
| title_sort | efficacy of synthetic peptide corresponding to the acth like sequence of human immunoglobulin g1 in experimental autoimmune encephalomyelitis |
| topic | multiple sclerosis peptide drugs immunosuppressors immunocortin animal model |
| url | http://journal.frontiersin.org/article/10.3389/fphar.2018.00113/full |
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