Efficacy of Synthetic Peptide Corresponding to the ACTH-Like Sequence of Human Immunoglobulin G1 in Experimental Autoimmune Encephalomyelitis

Efficacy of Synthetic Peptide Corresponding to the ACTH-Like Sequence of Human Immunoglobulin G1 in Experimental Autoimmune Encephalomyelitis

Peptide immunocortin sequence corresponds to the amino acid residues 11–20 of the variable part of human immunoglobulin G1 (IgG1) heavy chain. Since immunocortin was shown previously to inhibit phagocytosis in peritoneal macrophages and ConA-induced T-lymphocytes proliferation in culture, we suggest...

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Bibliographic Details
Main Authors: Valery I. Turobov, Alexey V. Danilkovich, Alexei B. Shevelev, Yulia K. Biryukova, Natalia V. Pozdniakova, Viatcheslav N. Azev, Arkady N. Murashev, Valery M. Lipkin, Igor P. Udovichenko
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Pharmacology
Subjects:
multiple sclerosis
peptide drugs
immunosuppressors
immunocortin
animal model
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2018.00113/full

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