Prenatal Fine Particulate Matter, Maternal Micronutrient Antioxidant Intake, and Early Childhood Repeated Wheeze: Effect Modification by Race/Ethnicity and Sex
Fine particulate matter (PM<sub>2.5</sub>) potentiates in utero oxidative stress influencing fetal development while antioxidants have potential protective effects. We examined associations among prenatal PM<sub>2.5</sub>, maternal antioxidant intake, and childhood wheeze in...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/11/2/366 |
| _version_ | 1797483190765486080 |
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| author | Yueh-Hsiu Mathilda Chiu Kecia N. Carroll Brent A. Coull Srimathi Kannan Ander Wilson Rosalind J. Wright |
| author_facet | Yueh-Hsiu Mathilda Chiu Kecia N. Carroll Brent A. Coull Srimathi Kannan Ander Wilson Rosalind J. Wright |
| author_sort | Yueh-Hsiu Mathilda Chiu |
| collection | DOAJ |
| description | Fine particulate matter (PM<sub>2.5</sub>) potentiates in utero oxidative stress influencing fetal development while antioxidants have potential protective effects. We examined associations among prenatal PM<sub>2.5</sub>, maternal antioxidant intake, and childhood wheeze in an urban pregnancy cohort (<i>n</i> = 530). Daily PM<sub>2.5</sub> exposure over gestation was estimated using a satellite-based spatiotemporally resolved model. Mothers completed the modified Block98 food frequency questionnaire. Average energy-adjusted percentile intake of β-carotene, vitamins (A, C, E), and trace minerals (zinc, magnesium, selenium) constituted an antioxidant index (AI). Maternal-reported child wheeze was ascertained up to 4.1 ± 2.8 years. Bayesian distributed lag interaction models (BDLIMs) were used to examine time-varying associations between prenatal PM<sub>2.5</sub> and repeated wheeze (≥2 episodes) and effect modification by AI, race/ethnicity, and child sex. Covariates included maternal age, education, asthma, and temperature. Women were 39% Black and 33% Hispanic, 36% with ≤high school education; 21% of children had repeated wheeze. Higher AI was associated with decreased wheeze in Blacks (OR = 0.37 (0.19–0.73), per IQR increase). BDLIMs identified a sensitive window for PM<sub>2.5</sub> effects on wheeze among boys born to Black mothers with low AI (at 33–40 weeks gestation; OR = 1.74 (1.19–2.54), per µg/m<sup>3</sup> increase in PM<sub>2.5</sub>). Relationships among prenatal PM<sub>2.5</sub>, antioxidant intake, and child wheeze were modified by race/ethnicity and sex. |
| first_indexed | 2024-03-09T22:43:23Z |
| format | Article |
| id | doaj.art-40327c3b3dca4339a8b7f63eb1a764b8 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-09T22:43:23Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-40327c3b3dca4339a8b7f63eb1a764b82023-11-23T18:32:42ZengMDPI AGAntioxidants2076-39212022-02-0111236610.3390/antiox11020366Prenatal Fine Particulate Matter, Maternal Micronutrient Antioxidant Intake, and Early Childhood Repeated Wheeze: Effect Modification by Race/Ethnicity and SexYueh-Hsiu Mathilda Chiu0Kecia N. Carroll1Brent A. Coull2Srimathi Kannan3Ander Wilson4Rosalind J. Wright5Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, P.O. Box 1057, New York, NY 10029, USADepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, P.O. Box 1057, New York, NY 10029, USADepartment of Biostatistics, Harvard TH Chan School of Public Health, Harvard University, Boston, MA 02115, USADivision of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48105, USADepartment of Statistics, Colorado State University, Fort Collins, CO 80523, USADepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, P.O. Box 1057, New York, NY 10029, USAFine particulate matter (PM<sub>2.5</sub>) potentiates in utero oxidative stress influencing fetal development while antioxidants have potential protective effects. We examined associations among prenatal PM<sub>2.5</sub>, maternal antioxidant intake, and childhood wheeze in an urban pregnancy cohort (<i>n</i> = 530). Daily PM<sub>2.5</sub> exposure over gestation was estimated using a satellite-based spatiotemporally resolved model. Mothers completed the modified Block98 food frequency questionnaire. Average energy-adjusted percentile intake of β-carotene, vitamins (A, C, E), and trace minerals (zinc, magnesium, selenium) constituted an antioxidant index (AI). Maternal-reported child wheeze was ascertained up to 4.1 ± 2.8 years. Bayesian distributed lag interaction models (BDLIMs) were used to examine time-varying associations between prenatal PM<sub>2.5</sub> and repeated wheeze (≥2 episodes) and effect modification by AI, race/ethnicity, and child sex. Covariates included maternal age, education, asthma, and temperature. Women were 39% Black and 33% Hispanic, 36% with ≤high school education; 21% of children had repeated wheeze. Higher AI was associated with decreased wheeze in Blacks (OR = 0.37 (0.19–0.73), per IQR increase). BDLIMs identified a sensitive window for PM<sub>2.5</sub> effects on wheeze among boys born to Black mothers with low AI (at 33–40 weeks gestation; OR = 1.74 (1.19–2.54), per µg/m<sup>3</sup> increase in PM<sub>2.5</sub>). Relationships among prenatal PM<sub>2.5</sub>, antioxidant intake, and child wheeze were modified by race/ethnicity and sex.https://www.mdpi.com/2076-3921/11/2/366prenatal air pollution exposurechildhood wheezeantioxidant intakerace and ethnicitysex differencedevelopmental origins of health and disease |
| spellingShingle | Yueh-Hsiu Mathilda Chiu Kecia N. Carroll Brent A. Coull Srimathi Kannan Ander Wilson Rosalind J. Wright Prenatal Fine Particulate Matter, Maternal Micronutrient Antioxidant Intake, and Early Childhood Repeated Wheeze: Effect Modification by Race/Ethnicity and Sex Antioxidants prenatal air pollution exposure childhood wheeze antioxidant intake race and ethnicity sex difference developmental origins of health and disease |
| title | Prenatal Fine Particulate Matter, Maternal Micronutrient Antioxidant Intake, and Early Childhood Repeated Wheeze: Effect Modification by Race/Ethnicity and Sex |
| title_full | Prenatal Fine Particulate Matter, Maternal Micronutrient Antioxidant Intake, and Early Childhood Repeated Wheeze: Effect Modification by Race/Ethnicity and Sex |
| title_fullStr | Prenatal Fine Particulate Matter, Maternal Micronutrient Antioxidant Intake, and Early Childhood Repeated Wheeze: Effect Modification by Race/Ethnicity and Sex |
| title_full_unstemmed | Prenatal Fine Particulate Matter, Maternal Micronutrient Antioxidant Intake, and Early Childhood Repeated Wheeze: Effect Modification by Race/Ethnicity and Sex |
| title_short | Prenatal Fine Particulate Matter, Maternal Micronutrient Antioxidant Intake, and Early Childhood Repeated Wheeze: Effect Modification by Race/Ethnicity and Sex |
| title_sort | prenatal fine particulate matter maternal micronutrient antioxidant intake and early childhood repeated wheeze effect modification by race ethnicity and sex |
| topic | prenatal air pollution exposure childhood wheeze antioxidant intake race and ethnicity sex difference developmental origins of health and disease |
| url | https://www.mdpi.com/2076-3921/11/2/366 |
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