Amelioration of oxidative stress, inflammation and tumor promotion by Tin oxide-Sodium alginate-Polyethylene glycol-Allyl isothiocyanate nanocomposites on the 1,2-Dimethylhydrazine induced colon carcinogenesis in rats
Background: Colorectal cancer (CRC) is a frequently diagnosed cancer that primarily affects the digestive system and an imperative cause of mortalities worldwide. Objective: In this work, we formulated the Tin oxide-Sodium alginate-Polyethylene glycol-Allyl isothiocyanate nanocomposites (SAP-Ally-NC...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-08-01
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| Series: | Arabian Journal of Chemistry |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878535221002537 |
| _version_ | 1818640378923843584 |
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| author | Wei Wei Rongxian Li Qinghang Liu Vidya Devanathadesikan Seshadri Vishnu Priya Veeraraghavan Krishna Mohan Surapaneni Thamaraiselvan Rengarajan |
| author_facet | Wei Wei Rongxian Li Qinghang Liu Vidya Devanathadesikan Seshadri Vishnu Priya Veeraraghavan Krishna Mohan Surapaneni Thamaraiselvan Rengarajan |
| author_sort | Wei Wei |
| collection | DOAJ |
| description | Background: Colorectal cancer (CRC) is a frequently diagnosed cancer that primarily affects the digestive system and an imperative cause of mortalities worldwide. Objective: In this work, we formulated the Tin oxide-Sodium alginate-Polyethylene glycol-Allyl isothiocyanate nanocomposites (SAP-Ally-NCs) and investigated its anticancer role against the DMH-provoked CRC in rats. Methodology: The formulated SAP-Ally-NCs were characterized different techniques. The CRC was provoked to the rats via injecting 20 mg/kg of DMH and then administered with the formulated SAP-Ally-NCs for 16 weeks. The bodyweight changes and the polyp’s incidences were detected and tabulated. The status of lipid peroxidation and antioxidant enzymes were studied by standard techniques. The inflammatory markers and xenobiotic enzymes level was scrutinized using respective kits. The mRNA expressions of various signaling molecules were examined by RT-PCR. The liver and colon tissues were examined microscopically to detect the histological changes. Results: The formulated SAP-Ally-NCs treatment appreciably improved the body weight gain and suppressed the polyp’s incidences in the DMH-challenged animals. SAP-Ally-NCs treated animals were demonstrated the notable reduction in the lipid peroxidation and inflammatory cytokines and elevated the antioxidant enzymes i.e. CAT and SOD activity. SAP-Ally-NCs administered animals exhibited the noticeable reduction in the expression of PCNA, cyclin-D1, iNOS, and COX-2 in the colon tissues. The histological findings also unveiled the therapeutic role of SAP-Ally-NCs. Conclusion: In conclusion, the SAP-Ally-NCs demonstrated the potent anticancer action against the DMH-provoked CRC in rats. In future, it could be a potent chemotherapeutic agent to the CRC. |
| first_indexed | 2024-12-16T23:10:20Z |
| format | Article |
| id | doaj.art-40332831eec14764bbdfba5954155596 |
| institution | Directory Open Access Journal |
| issn | 1878-5352 |
| language | English |
| last_indexed | 2024-12-16T23:10:20Z |
| publishDate | 2021-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Arabian Journal of Chemistry |
| spelling | doaj.art-40332831eec14764bbdfba59541555962022-12-21T22:12:26ZengElsevierArabian Journal of Chemistry1878-53522021-08-01148103238Amelioration of oxidative stress, inflammation and tumor promotion by Tin oxide-Sodium alginate-Polyethylene glycol-Allyl isothiocyanate nanocomposites on the 1,2-Dimethylhydrazine induced colon carcinogenesis in ratsWei Wei0Rongxian Li1Qinghang Liu2Vidya Devanathadesikan Seshadri3Vishnu Priya Veeraraghavan4Krishna Mohan Surapaneni5Thamaraiselvan Rengarajan6Department of Anorectal, Xinxiang Central Hospital, The Fourth Clinical College of Xinxiang Medical University, Xinxiang City, Henan Province 453000, ChinaDepartment of Anorectal, Xinxiang Central Hospital, The Fourth Clinical College of Xinxiang Medical University, Xinxiang City, Henan Province 453000, ChinaDepartment of Anorectal, Xinxiang Central Hospital, The Fourth Clinical College of Xinxiang Medical University, Xinxiang City, Henan Province 453000, ChinaDepartment of Pharmacology & Toxicology, College of Pharmacy, Prince Sattam Bin Abdul Aziz University, Al-Kharj, Saudi ArabiaDepartment of Biochemistry, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai 600 077, IndiaDepartment of Biochemistry, Panimalar Medical College Hospital & Research Institute, Varadharajapuram, Poonamallee, Chennai 600 123, IndiaScigen Research and Innovation Pvt. Ltd., Periyar Technology Business Incubator, Thanjavur, Tamil Nadu, India; Corresponding author.Background: Colorectal cancer (CRC) is a frequently diagnosed cancer that primarily affects the digestive system and an imperative cause of mortalities worldwide. Objective: In this work, we formulated the Tin oxide-Sodium alginate-Polyethylene glycol-Allyl isothiocyanate nanocomposites (SAP-Ally-NCs) and investigated its anticancer role against the DMH-provoked CRC in rats. Methodology: The formulated SAP-Ally-NCs were characterized different techniques. The CRC was provoked to the rats via injecting 20 mg/kg of DMH and then administered with the formulated SAP-Ally-NCs for 16 weeks. The bodyweight changes and the polyp’s incidences were detected and tabulated. The status of lipid peroxidation and antioxidant enzymes were studied by standard techniques. The inflammatory markers and xenobiotic enzymes level was scrutinized using respective kits. The mRNA expressions of various signaling molecules were examined by RT-PCR. The liver and colon tissues were examined microscopically to detect the histological changes. Results: The formulated SAP-Ally-NCs treatment appreciably improved the body weight gain and suppressed the polyp’s incidences in the DMH-challenged animals. SAP-Ally-NCs treated animals were demonstrated the notable reduction in the lipid peroxidation and inflammatory cytokines and elevated the antioxidant enzymes i.e. CAT and SOD activity. SAP-Ally-NCs administered animals exhibited the noticeable reduction in the expression of PCNA, cyclin-D1, iNOS, and COX-2 in the colon tissues. The histological findings also unveiled the therapeutic role of SAP-Ally-NCs. Conclusion: In conclusion, the SAP-Ally-NCs demonstrated the potent anticancer action against the DMH-provoked CRC in rats. In future, it could be a potent chemotherapeutic agent to the CRC.http://www.sciencedirect.com/science/article/pii/S1878535221002537Colon cancerOxidative stressInflammationAllyl isothiocyanate1,2-Dimethyl hydrazine |
| spellingShingle | Wei Wei Rongxian Li Qinghang Liu Vidya Devanathadesikan Seshadri Vishnu Priya Veeraraghavan Krishna Mohan Surapaneni Thamaraiselvan Rengarajan Amelioration of oxidative stress, inflammation and tumor promotion by Tin oxide-Sodium alginate-Polyethylene glycol-Allyl isothiocyanate nanocomposites on the 1,2-Dimethylhydrazine induced colon carcinogenesis in rats Arabian Journal of Chemistry Colon cancer Oxidative stress Inflammation Allyl isothiocyanate 1,2-Dimethyl hydrazine |
| title | Amelioration of oxidative stress, inflammation and tumor promotion by Tin oxide-Sodium alginate-Polyethylene glycol-Allyl isothiocyanate nanocomposites on the 1,2-Dimethylhydrazine induced colon carcinogenesis in rats |
| title_full | Amelioration of oxidative stress, inflammation and tumor promotion by Tin oxide-Sodium alginate-Polyethylene glycol-Allyl isothiocyanate nanocomposites on the 1,2-Dimethylhydrazine induced colon carcinogenesis in rats |
| title_fullStr | Amelioration of oxidative stress, inflammation and tumor promotion by Tin oxide-Sodium alginate-Polyethylene glycol-Allyl isothiocyanate nanocomposites on the 1,2-Dimethylhydrazine induced colon carcinogenesis in rats |
| title_full_unstemmed | Amelioration of oxidative stress, inflammation and tumor promotion by Tin oxide-Sodium alginate-Polyethylene glycol-Allyl isothiocyanate nanocomposites on the 1,2-Dimethylhydrazine induced colon carcinogenesis in rats |
| title_short | Amelioration of oxidative stress, inflammation and tumor promotion by Tin oxide-Sodium alginate-Polyethylene glycol-Allyl isothiocyanate nanocomposites on the 1,2-Dimethylhydrazine induced colon carcinogenesis in rats |
| title_sort | amelioration of oxidative stress inflammation and tumor promotion by tin oxide sodium alginate polyethylene glycol allyl isothiocyanate nanocomposites on the 1 2 dimethylhydrazine induced colon carcinogenesis in rats |
| topic | Colon cancer Oxidative stress Inflammation Allyl isothiocyanate 1,2-Dimethyl hydrazine |
| url | http://www.sciencedirect.com/science/article/pii/S1878535221002537 |
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