Effects of Chrysoeriol on Adipogenesis and Lipolysis in 3T3-L1 Adipocytes
We examined the effect of chrysoeriol on adipogenesis and lipolysis and elucidated the underlying molecular mechanisms. Chrysoeriol inhibited fat deposition in adipocytes. Treatment with chrysoeriol suppressed the expression of peroxisome proliferator-activated receptor γ, fatty acid synthase, fatty...
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| Format: | Article |
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MDPI AG
2022-12-01
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| Series: | Foods |
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| Online Access: | https://www.mdpi.com/2304-8158/12/1/172 |
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| author | Jinhee Song Hana Lee Huijin Heo Junsoo Lee Younghwa Kim |
| author_facet | Jinhee Song Hana Lee Huijin Heo Junsoo Lee Younghwa Kim |
| author_sort | Jinhee Song |
| collection | DOAJ |
| description | We examined the effect of chrysoeriol on adipogenesis and lipolysis and elucidated the underlying molecular mechanisms. Chrysoeriol inhibited fat deposition in adipocytes. Treatment with chrysoeriol suppressed the expression of peroxisome proliferator-activated receptor γ, fatty acid synthase, fatty acid-binding protein, CCAAT/enhancer-binding proteins (C/EBP) α, C/EBPβ, and sterol regulatory element-binding protein-1. In addition, chrysoeriol significantly elevated the activation of 5′-adenosine monophosphate-activated protein kinase. Moreover, chrysoeriol increased free glycerol and fatty acid levels and promoted lipolysis in adipocytes. Overexpression of adipose triglyceride lipase and hormone-sensitive lipase by chrysoeriol led to increased lipolysis in 3T3-L1 adipocytes. Taken together, chrysoeriol showed anti-adipogenic and lipolytic properties in adipocytes. |
| first_indexed | 2024-03-11T10:00:40Z |
| format | Article |
| id | doaj.art-4033bcbe214344fba4accf312b60cb61 |
| institution | Directory Open Access Journal |
| issn | 2304-8158 |
| language | English |
| last_indexed | 2024-03-11T10:00:40Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Foods |
| spelling | doaj.art-4033bcbe214344fba4accf312b60cb612023-11-16T15:23:23ZengMDPI AGFoods2304-81582022-12-0112117210.3390/foods12010172Effects of Chrysoeriol on Adipogenesis and Lipolysis in 3T3-L1 AdipocytesJinhee Song0Hana Lee1Huijin Heo2Junsoo Lee3Younghwa Kim4Department of Food Science and Biotechnology, Chungbuk National University, Cheongju 28644, Republic of KoreaDepartment of Food Science and Biotechnology, Chungbuk National University, Cheongju 28644, Republic of KoreaDepartment of Food Science and Biotechnology, Chungbuk National University, Cheongju 28644, Republic of KoreaDepartment of Food Science and Biotechnology, Chungbuk National University, Cheongju 28644, Republic of KoreaDepartment of Food Science and Biotechnology, Kyungsung University, Busan 48434, Republic of KoreaWe examined the effect of chrysoeriol on adipogenesis and lipolysis and elucidated the underlying molecular mechanisms. Chrysoeriol inhibited fat deposition in adipocytes. Treatment with chrysoeriol suppressed the expression of peroxisome proliferator-activated receptor γ, fatty acid synthase, fatty acid-binding protein, CCAAT/enhancer-binding proteins (C/EBP) α, C/EBPβ, and sterol regulatory element-binding protein-1. In addition, chrysoeriol significantly elevated the activation of 5′-adenosine monophosphate-activated protein kinase. Moreover, chrysoeriol increased free glycerol and fatty acid levels and promoted lipolysis in adipocytes. Overexpression of adipose triglyceride lipase and hormone-sensitive lipase by chrysoeriol led to increased lipolysis in 3T3-L1 adipocytes. Taken together, chrysoeriol showed anti-adipogenic and lipolytic properties in adipocytes.https://www.mdpi.com/2304-8158/12/1/172chrysoerioladipogenesislipolysisAMPK pathwayadipocytes |
| spellingShingle | Jinhee Song Hana Lee Huijin Heo Junsoo Lee Younghwa Kim Effects of Chrysoeriol on Adipogenesis and Lipolysis in 3T3-L1 Adipocytes Foods chrysoeriol adipogenesis lipolysis AMPK pathway adipocytes |
| title | Effects of Chrysoeriol on Adipogenesis and Lipolysis in 3T3-L1 Adipocytes |
| title_full | Effects of Chrysoeriol on Adipogenesis and Lipolysis in 3T3-L1 Adipocytes |
| title_fullStr | Effects of Chrysoeriol on Adipogenesis and Lipolysis in 3T3-L1 Adipocytes |
| title_full_unstemmed | Effects of Chrysoeriol on Adipogenesis and Lipolysis in 3T3-L1 Adipocytes |
| title_short | Effects of Chrysoeriol on Adipogenesis and Lipolysis in 3T3-L1 Adipocytes |
| title_sort | effects of chrysoeriol on adipogenesis and lipolysis in 3t3 l1 adipocytes |
| topic | chrysoeriol adipogenesis lipolysis AMPK pathway adipocytes |
| url | https://www.mdpi.com/2304-8158/12/1/172 |
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