BMP4 drives primed to naïve transition through PGC-like state
Multiple pluripotent states have been described in mouse and human stem cells. Here the authors describe trajectories during BMP4 induced primed to naïve transition, which bifurcates into naïve and trophoblast-like branches with a PGC-like intermediate at the naïve branch.
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-30325-4 |
| _version_ | 1818549627492761600 |
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| author | Shengyong Yu Chunhua Zhou Jiangping He Zhaokai Yao Xingnan Huang Bowen Rong Hong Zhu Shijie Wang Shuyan Chen Xialian Wang Baomei Cai Guoqing Zhao Yuhan Chen Lizhan Xiao He Liu Yue Qin Jing Guo Haokaifeng Wu Zhen Zhang Man Zhang Xiaoyang Zhao Fei Lan Yixuan Wang Jiekai Chen Shangtao Cao Duanqing Pei Jing Liu |
| author_facet | Shengyong Yu Chunhua Zhou Jiangping He Zhaokai Yao Xingnan Huang Bowen Rong Hong Zhu Shijie Wang Shuyan Chen Xialian Wang Baomei Cai Guoqing Zhao Yuhan Chen Lizhan Xiao He Liu Yue Qin Jing Guo Haokaifeng Wu Zhen Zhang Man Zhang Xiaoyang Zhao Fei Lan Yixuan Wang Jiekai Chen Shangtao Cao Duanqing Pei Jing Liu |
| author_sort | Shengyong Yu |
| collection | DOAJ |
| description | Multiple pluripotent states have been described in mouse and human stem cells. Here the authors describe trajectories during BMP4 induced primed to naïve transition, which bifurcates into naïve and trophoblast-like branches with a PGC-like intermediate at the naïve branch. |
| first_indexed | 2024-12-12T08:35:49Z |
| format | Article |
| id | doaj.art-4036486e588644698f0929c8f7056c13 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-12T08:35:49Z |
| publishDate | 2022-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-4036486e588644698f0929c8f7056c132022-12-22T00:30:57ZengNature PortfolioNature Communications2041-17232022-05-0113111510.1038/s41467-022-30325-4BMP4 drives primed to naïve transition through PGC-like stateShengyong Yu0Chunhua Zhou1Jiangping He2Zhaokai Yao3Xingnan Huang4Bowen Rong5Hong Zhu6Shijie Wang7Shuyan Chen8Xialian Wang9Baomei Cai10Guoqing Zhao11Yuhan Chen12Lizhan Xiao13He Liu14Yue Qin15Jing Guo16Haokaifeng Wu17Zhen Zhang18Man Zhang19Xiaoyang Zhao20Fei Lan21Yixuan Wang22Jiekai Chen23Shangtao Cao24Duanqing Pei25Jing Liu26Center for Cell Lineage and Development, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of SciencesCenter for Cell Lineage and Development, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of SciencesCenter for Cell Lineage and Atlas, Bioland LaboratoryState Key Laboratory of Organ Failure Research, Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical UniversityLaboratory of Cell Fate Control, School of Life Sciences, Westlake UniversityShanghai Key Laboratory of Medical Epigenetics, State International Co-laboratory of Medical Epigenetics and Metabolism, Institutes of Biomedical Sciences, Fudan University, and Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Liver Cancer Institute, Zhongshan Hospital, Fudan UniversityCenter for Cell Lineage and Development, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of SciencesGMU-GIBH Joint School of Life Sciences, Guangzhou Medical UniversityCenter for Cell Lineage and Development, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of SciencesGMU-GIBH Joint School of Life Sciences, Guangzhou Medical UniversityCenter for Cell Lineage and Atlas, Bioland LaboratoryCenter for Cell Lineage and Atlas, Bioland LaboratoryState Key Laboratory of Organ Failure Research, Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical UniversityCenter for Cell Lineage and Atlas, Bioland LaboratoryCenter for Cell Lineage and Atlas, Bioland LaboratoryCenter for Cell Lineage and Development, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of SciencesCenter for Cell Lineage and Development, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of SciencesCenter for Cell Lineage and Development, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of SciencesCenter for Cell Lineage and Development, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of SciencesCenter for Cell Lineage and Atlas, Bioland LaboratoryState Key Laboratory of Organ Failure Research, Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical UniversityShanghai Key Laboratory of Medical Epigenetics, State International Co-laboratory of Medical Epigenetics and Metabolism, Institutes of Biomedical Sciences, Fudan University, and Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Liver Cancer Institute, Zhongshan Hospital, Fudan UniversityCenter for Cell Lineage and Development, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of SciencesCenter for Cell Lineage and Development, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of SciencesCenter for Cell Lineage and Atlas, Bioland LaboratoryLaboratory of Cell Fate Control, School of Life Sciences, Westlake UniversityCenter for Cell Lineage and Development, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of SciencesMultiple pluripotent states have been described in mouse and human stem cells. Here the authors describe trajectories during BMP4 induced primed to naïve transition, which bifurcates into naïve and trophoblast-like branches with a PGC-like intermediate at the naïve branch.https://doi.org/10.1038/s41467-022-30325-4 |
| spellingShingle | Shengyong Yu Chunhua Zhou Jiangping He Zhaokai Yao Xingnan Huang Bowen Rong Hong Zhu Shijie Wang Shuyan Chen Xialian Wang Baomei Cai Guoqing Zhao Yuhan Chen Lizhan Xiao He Liu Yue Qin Jing Guo Haokaifeng Wu Zhen Zhang Man Zhang Xiaoyang Zhao Fei Lan Yixuan Wang Jiekai Chen Shangtao Cao Duanqing Pei Jing Liu BMP4 drives primed to naïve transition through PGC-like state Nature Communications |
| title | BMP4 drives primed to naïve transition through PGC-like state |
| title_full | BMP4 drives primed to naïve transition through PGC-like state |
| title_fullStr | BMP4 drives primed to naïve transition through PGC-like state |
| title_full_unstemmed | BMP4 drives primed to naïve transition through PGC-like state |
| title_short | BMP4 drives primed to naïve transition through PGC-like state |
| title_sort | bmp4 drives primed to naive transition through pgc like state |
| url | https://doi.org/10.1038/s41467-022-30325-4 |
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