Involvement of superior colliculus in complex figure detection of mice
Object detection is an essential function of the visual system. Although the visual cortex plays an important role in object detection, the superior colliculus can support detection when the visual cortex is ablated or silenced. Moreover, it has been shown that superficial layers of mouse SC (sSC) e...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2024-01-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/83708 |
| _version_ | 1797346487761371136 |
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| author | J Leonie Cazemier Robin Haak TK Loan Tran Ann TY Hsu Medina Husic Brandon D Peri Lisa Kirchberger Matthew W Self Pieter Roelfsema J Alexander Heimel |
| author_facet | J Leonie Cazemier Robin Haak TK Loan Tran Ann TY Hsu Medina Husic Brandon D Peri Lisa Kirchberger Matthew W Self Pieter Roelfsema J Alexander Heimel |
| author_sort | J Leonie Cazemier |
| collection | DOAJ |
| description | Object detection is an essential function of the visual system. Although the visual cortex plays an important role in object detection, the superior colliculus can support detection when the visual cortex is ablated or silenced. Moreover, it has been shown that superficial layers of mouse SC (sSC) encode visual features of complex objects, and that this code is not inherited from the primary visual cortex. This suggests that mouse sSC may provide a significant contribution to complex object vision. Here, we use optogenetics to show that mouse sSC is involved in figure detection based on differences in figure contrast, orientation, and phase. Additionally, our neural recordings show that in mouse sSC, image elements that belong to a figure elicit stronger activity than those same elements when they are part of the background. The discriminability of this neural code is higher for correct trials than for incorrect trials. Our results provide new insight into the behavioral relevance of the visual processing that takes place in sSC. |
| first_indexed | 2024-03-08T11:34:11Z |
| format | Article |
| id | doaj.art-40377a451fab4f6fadaad07d5953e4ac |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-03-08T11:34:11Z |
| publishDate | 2024-01-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-40377a451fab4f6fadaad07d5953e4ac2024-01-25T15:29:47ZengeLife Sciences Publications LtdeLife2050-084X2024-01-011310.7554/eLife.83708Involvement of superior colliculus in complex figure detection of miceJ Leonie Cazemier0https://orcid.org/0000-0003-2875-6283Robin Haak1TK Loan Tran2Ann TY Hsu3Medina Husic4Brandon D Peri5Lisa Kirchberger6Matthew W Self7https://orcid.org/0000-0001-5731-579XPieter Roelfsema8https://orcid.org/0000-0002-1625-0034J Alexander Heimel9https://orcid.org/0000-0002-5291-4184Department of Circuits, Structure & Function, The Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences (KNAW), Amsterdam, NetherlandsDepartment of Circuits, Structure & Function, The Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences (KNAW), Amsterdam, NetherlandsDepartment of Circuits, Structure & Function, The Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences (KNAW), Amsterdam, NetherlandsDepartment of Circuits, Structure & Function, The Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences (KNAW), Amsterdam, NetherlandsDepartment of Circuits, Structure & Function, The Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences (KNAW), Amsterdam, NetherlandsDepartment of Circuits, Structure & Function, The Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences (KNAW), Amsterdam, NetherlandsDepartment of Vision and Cognition, The Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences (KNAW), Amsterdam, NetherlandsDepartment of Vision and Cognition, The Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences (KNAW), Amsterdam, NetherlandsDepartment of Vision and Cognition, The Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences (KNAW), Amsterdam, Netherlands; Department of Integrative Neurophysiology, VU University, Amsterdam, Netherlands; Department of Psychiatry, Academic Medical Centre, Amsterdam, Netherlands; Laboratory of Visual Brain Therapy, Sorbonne Université, Institut National de la Santé et de la Recherche Médicale, Centre National de la Recherche Scientifique, Institut de la Vision, Paris, FranceDepartment of Circuits, Structure & Function, The Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences (KNAW), Amsterdam, NetherlandsObject detection is an essential function of the visual system. Although the visual cortex plays an important role in object detection, the superior colliculus can support detection when the visual cortex is ablated or silenced. Moreover, it has been shown that superficial layers of mouse SC (sSC) encode visual features of complex objects, and that this code is not inherited from the primary visual cortex. This suggests that mouse sSC may provide a significant contribution to complex object vision. Here, we use optogenetics to show that mouse sSC is involved in figure detection based on differences in figure contrast, orientation, and phase. Additionally, our neural recordings show that in mouse sSC, image elements that belong to a figure elicit stronger activity than those same elements when they are part of the background. The discriminability of this neural code is higher for correct trials than for incorrect trials. Our results provide new insight into the behavioral relevance of the visual processing that takes place in sSC.https://elifesciences.org/articles/83708superior colliculusvisionelectrophysiologyobject detectionoptogenetics |
| spellingShingle | J Leonie Cazemier Robin Haak TK Loan Tran Ann TY Hsu Medina Husic Brandon D Peri Lisa Kirchberger Matthew W Self Pieter Roelfsema J Alexander Heimel Involvement of superior colliculus in complex figure detection of mice eLife superior colliculus vision electrophysiology object detection optogenetics |
| title | Involvement of superior colliculus in complex figure detection of mice |
| title_full | Involvement of superior colliculus in complex figure detection of mice |
| title_fullStr | Involvement of superior colliculus in complex figure detection of mice |
| title_full_unstemmed | Involvement of superior colliculus in complex figure detection of mice |
| title_short | Involvement of superior colliculus in complex figure detection of mice |
| title_sort | involvement of superior colliculus in complex figure detection of mice |
| topic | superior colliculus vision electrophysiology object detection optogenetics |
| url | https://elifesciences.org/articles/83708 |
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