Significant Association Between Bone-Specific Alkaline Phosphatase and Vascular Calcification of the Hand Arteries in Male Hemodialysis Patients
Background/Aims: Bone-specific alkaline phosphatase (BAP) hydrolyzes pyrophosphate, which inhibits vascular calcification. We examined association between serum BAP and vascular calcification of male hemodialysis patients. Methods: Hand roentgenography of 167 male maintenance hemodialysis patients w...
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| Format: | Article |
| Language: | English |
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Karger Publishers
2014-09-01
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| Series: | Kidney & Blood Pressure Research |
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| Online Access: | http://www.karger.com/Article/FullText/355807 |
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| author | Eiji Ishimura Senji Okuno Hisanori Okazaki Kyoko Norimine Kenjiro Yamakawa Tomoyuki Yamakawa Shigeichi Shoji Yoshiki Nishizawa Masaaki Inaba |
| author_facet | Eiji Ishimura Senji Okuno Hisanori Okazaki Kyoko Norimine Kenjiro Yamakawa Tomoyuki Yamakawa Shigeichi Shoji Yoshiki Nishizawa Masaaki Inaba |
| author_sort | Eiji Ishimura |
| collection | DOAJ |
| description | Background/Aims: Bone-specific alkaline phosphatase (BAP) hydrolyzes pyrophosphate, which inhibits vascular calcification. We examined association between serum BAP and vascular calcification of male hemodialysis patients. Methods: Hand roentgenography of 167 male maintenance hemodialysis patients was conducted, and visible vascular calcification of the hand arteries was evaluated. Serum levels of 3 bone formation markers (BAP, osteocalcin, and N-terminal propeptide of type I collagen) and 2 bone resorption markers (C-terminal telopeptide of type I collagen, and cross-linked N-telopeptide of type I collagen) were measured, along with serum intact parathyroid hormone (PTH). Results: Of 167 patients, visible vascular calcification was seen in 37 patients. Among the bone formation and resorption markers, serum BAP was significantly higher in patients with vascular calcification than in those without (pConclusions: Higher serum BAP, but not other bone markers, is significantly associated with the presence of vascular calcification in male hemodialysis patients. |
| first_indexed | 2024-12-11T22:24:07Z |
| format | Article |
| id | doaj.art-40378681873a440a83934928b5c5ab6d |
| institution | Directory Open Access Journal |
| issn | 1420-4096 1423-0143 |
| language | English |
| last_indexed | 2024-12-11T22:24:07Z |
| publishDate | 2014-09-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Kidney & Blood Pressure Research |
| spelling | doaj.art-40378681873a440a83934928b5c5ab6d2022-12-22T00:48:21ZengKarger PublishersKidney & Blood Pressure Research1420-40961423-01432014-09-0139429930710.1159/000355807355807Significant Association Between Bone-Specific Alkaline Phosphatase and Vascular Calcification of the Hand Arteries in Male Hemodialysis PatientsEiji IshimuraSenji OkunoHisanori OkazakiKyoko NorimineKenjiro YamakawaTomoyuki YamakawaShigeichi ShojiYoshiki NishizawaMasaaki InabaBackground/Aims: Bone-specific alkaline phosphatase (BAP) hydrolyzes pyrophosphate, which inhibits vascular calcification. We examined association between serum BAP and vascular calcification of male hemodialysis patients. Methods: Hand roentgenography of 167 male maintenance hemodialysis patients was conducted, and visible vascular calcification of the hand arteries was evaluated. Serum levels of 3 bone formation markers (BAP, osteocalcin, and N-terminal propeptide of type I collagen) and 2 bone resorption markers (C-terminal telopeptide of type I collagen, and cross-linked N-telopeptide of type I collagen) were measured, along with serum intact parathyroid hormone (PTH). Results: Of 167 patients, visible vascular calcification was seen in 37 patients. Among the bone formation and resorption markers, serum BAP was significantly higher in patients with vascular calcification than in those without (pConclusions: Higher serum BAP, but not other bone markers, is significantly associated with the presence of vascular calcification in male hemodialysis patients.http://www.karger.com/Article/FullText/355807Bone formation markersBone resorption markersHemodialysisVascular calcificationBone-specific alkaline phosphatase |
| spellingShingle | Eiji Ishimura Senji Okuno Hisanori Okazaki Kyoko Norimine Kenjiro Yamakawa Tomoyuki Yamakawa Shigeichi Shoji Yoshiki Nishizawa Masaaki Inaba Significant Association Between Bone-Specific Alkaline Phosphatase and Vascular Calcification of the Hand Arteries in Male Hemodialysis Patients Kidney & Blood Pressure Research Bone formation markers Bone resorption markers Hemodialysis Vascular calcification Bone-specific alkaline phosphatase |
| title | Significant Association Between Bone-Specific Alkaline Phosphatase and Vascular Calcification of the Hand Arteries in Male Hemodialysis Patients |
| title_full | Significant Association Between Bone-Specific Alkaline Phosphatase and Vascular Calcification of the Hand Arteries in Male Hemodialysis Patients |
| title_fullStr | Significant Association Between Bone-Specific Alkaline Phosphatase and Vascular Calcification of the Hand Arteries in Male Hemodialysis Patients |
| title_full_unstemmed | Significant Association Between Bone-Specific Alkaline Phosphatase and Vascular Calcification of the Hand Arteries in Male Hemodialysis Patients |
| title_short | Significant Association Between Bone-Specific Alkaline Phosphatase and Vascular Calcification of the Hand Arteries in Male Hemodialysis Patients |
| title_sort | significant association between bone specific alkaline phosphatase and vascular calcification of the hand arteries in male hemodialysis patients |
| topic | Bone formation markers Bone resorption markers Hemodialysis Vascular calcification Bone-specific alkaline phosphatase |
| url | http://www.karger.com/Article/FullText/355807 |
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