Combination of nitrous oxide and lidocaine to prevent withdrawal after rocuronium in children
BackgroundPain at the site of rocuronium injection is a common side-effect in pediatric patients. This prospective, randomized, double-blind study evaluated the efficacy of a combination of nitrous oxide and lidocaine pretreatment on withdrawal response during rocuronium injection in children.Method...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Korean Society of Anesthesiologists
2010-05-01
|
| Series: | Korean Journal of Anesthesiology |
| Subjects: | |
| Online Access: | http://ekja.org/upload/pdf/kjae-58-446.pdf |
| _version_ | 1819073783770644480 |
|---|---|
| author | Hyun-Jeong Kwak Yun Jeong Chae Sook Young Lee Young Jun Kim Jong-Yeop Kim |
| author_facet | Hyun-Jeong Kwak Yun Jeong Chae Sook Young Lee Young Jun Kim Jong-Yeop Kim |
| author_sort | Hyun-Jeong Kwak |
| collection | DOAJ |
| description | BackgroundPain at the site of rocuronium injection is a common side-effect in pediatric patients. This prospective, randomized, double-blind study evaluated the efficacy of a combination of nitrous oxide and lidocaine pretreatment on withdrawal response during rocuronium injection in children.MethodsSixty six pediatric patients, ages 5 to 12 years, were randomly assigned to two groups. The oxygen group received 100% oxygen, and the nitrous oxide group received 50% N2O in oxygen over 2 min. After anesthesia was induced with 2.5% thiopental sodium 5 mg/kg and manual occlusion of the forearm was performed, 1% lidocaine 1 mg/kg was injected over 15 sec. After the occlusion was released, 0.1% rocuronium 0.6 mg/kg was injected over 5 sec. Patient response to rocuronium injection was graded using a 4-point scale.ResultsOverall incidence of withdrawal movements was significantly lower in the nitrous oxide group (1 patients; 3.1%) than in the oxygen group (8 patients; 25.8%) (P = 0.013). No patient in the nitrous oxide group displayed arm or generalized movement (grade 3 or 4) associated with rocuronium injection.ConclusionsThis study demonstrated that a combination of inhaled 50% N2O in O2 and 1 mg/kg lidocaine pretreatment significantly reduced the incidence of rocuronium-induced withdrawal movements in pediatric patients compared with lidocaine pretreatment alone. |
| first_indexed | 2024-12-21T17:59:07Z |
| format | Article |
| id | doaj.art-4038a546d8104dd3822c31102dec424d |
| institution | Directory Open Access Journal |
| issn | 2005-6419 2005-7563 |
| language | English |
| last_indexed | 2024-12-21T17:59:07Z |
| publishDate | 2010-05-01 |
| publisher | Korean Society of Anesthesiologists |
| record_format | Article |
| series | Korean Journal of Anesthesiology |
| spelling | doaj.art-4038a546d8104dd3822c31102dec424d2022-12-21T18:55:07ZengKorean Society of AnesthesiologistsKorean Journal of Anesthesiology2005-64192005-75632010-05-0158544644910.4097/kjae.2010.58.5.4466898Combination of nitrous oxide and lidocaine to prevent withdrawal after rocuronium in childrenHyun-Jeong Kwak0Yun Jeong Chae1Sook Young Lee2Young Jun Kim3Jong-Yeop Kim4Department of Anesthesiology and Pain Medicine, Gil Medical Center, Gachon University of Medicine and Science, Incheon, Korea.Department of Anesthesiology and Pain Medicine, Ajou University School of Medicine, Suwon, Korea.Department of Anesthesiology and Pain Medicine, Ajou University School of Medicine, Suwon, Korea.Department of Anesthesiology and Pain Medicine, Ajou University School of Medicine, Suwon, Korea.Department of Anesthesiology and Pain Medicine, Ajou University School of Medicine, Suwon, Korea.BackgroundPain at the site of rocuronium injection is a common side-effect in pediatric patients. This prospective, randomized, double-blind study evaluated the efficacy of a combination of nitrous oxide and lidocaine pretreatment on withdrawal response during rocuronium injection in children.MethodsSixty six pediatric patients, ages 5 to 12 years, were randomly assigned to two groups. The oxygen group received 100% oxygen, and the nitrous oxide group received 50% N2O in oxygen over 2 min. After anesthesia was induced with 2.5% thiopental sodium 5 mg/kg and manual occlusion of the forearm was performed, 1% lidocaine 1 mg/kg was injected over 15 sec. After the occlusion was released, 0.1% rocuronium 0.6 mg/kg was injected over 5 sec. Patient response to rocuronium injection was graded using a 4-point scale.ResultsOverall incidence of withdrawal movements was significantly lower in the nitrous oxide group (1 patients; 3.1%) than in the oxygen group (8 patients; 25.8%) (P = 0.013). No patient in the nitrous oxide group displayed arm or generalized movement (grade 3 or 4) associated with rocuronium injection.ConclusionsThis study demonstrated that a combination of inhaled 50% N2O in O2 and 1 mg/kg lidocaine pretreatment significantly reduced the incidence of rocuronium-induced withdrawal movements in pediatric patients compared with lidocaine pretreatment alone.http://ekja.org/upload/pdf/kjae-58-446.pdflidocainenitrous oxiderocuroniumwithdrawal |
| spellingShingle | Hyun-Jeong Kwak Yun Jeong Chae Sook Young Lee Young Jun Kim Jong-Yeop Kim Combination of nitrous oxide and lidocaine to prevent withdrawal after rocuronium in children Korean Journal of Anesthesiology lidocaine nitrous oxide rocuronium withdrawal |
| title | Combination of nitrous oxide and lidocaine to prevent withdrawal after rocuronium in children |
| title_full | Combination of nitrous oxide and lidocaine to prevent withdrawal after rocuronium in children |
| title_fullStr | Combination of nitrous oxide and lidocaine to prevent withdrawal after rocuronium in children |
| title_full_unstemmed | Combination of nitrous oxide and lidocaine to prevent withdrawal after rocuronium in children |
| title_short | Combination of nitrous oxide and lidocaine to prevent withdrawal after rocuronium in children |
| title_sort | combination of nitrous oxide and lidocaine to prevent withdrawal after rocuronium in children |
| topic | lidocaine nitrous oxide rocuronium withdrawal |
| url | http://ekja.org/upload/pdf/kjae-58-446.pdf |
| work_keys_str_mv | AT hyunjeongkwak combinationofnitrousoxideandlidocainetopreventwithdrawalafterrocuroniuminchildren AT yunjeongchae combinationofnitrousoxideandlidocainetopreventwithdrawalafterrocuroniuminchildren AT sookyounglee combinationofnitrousoxideandlidocainetopreventwithdrawalafterrocuroniuminchildren AT youngjunkim combinationofnitrousoxideandlidocainetopreventwithdrawalafterrocuroniuminchildren AT jongyeopkim combinationofnitrousoxideandlidocainetopreventwithdrawalafterrocuroniuminchildren |