Susceptibility of Toxoplasma gondii to autophagy in human cells relies on multiple interacting parasite loci

Susceptibility of Toxoplasma gondii to autophagy in human cells relies on multiple interacting parasite loci

ABSTRACTAutophagy contributes to innate immunity by targeting intracellular pathogens for elimination. Previous studies identified a non-canonical autophagy pathway that controls Toxoplasma gondii infection in a strain-dependent manner in interferon gamma-activated human cells. Ubiquitination of unk...

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Bibliographic Details
Main Authors: Nicholas Rinkenberger, Alex Rosenberg, Joshua B. Radke, Jaya Bhushan, Tadakimi Tomita, Louis M. Weiss, L. David Sibley
Format: Article
Language:English
Published: American Society for Microbiology 2024-01-01
Series:mBio
Subjects:
intracellular parasite
genetic mapping
quantitative trait locus
linkage analysis
secretory proteins
dense granule proteins
Online Access:https://journals.asm.org/doi/10.1128/mbio.02595-23

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