Rare variant analysis for family-based design.

Rare variant analysis for family-based design.

Genome-wide association studies have been able to identify disease associations with many common variants; however most of the estimated genetic contribution explained by these variants appears to be very modest. Rare variants are thought to have larger effect sizes compared to common SNPs but effec...

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Bibliographic Details
Main Authors:	Gourab De, Wai-Ki Yip, Iuliana Ionita-Laza, Nan Laird
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2013-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC3546113?pdf=render

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