Study on the antiepyleptic activity of the new amide derivative of valproic acid and 1,3,4-thiadiazole
Aim – experimental evaluation of the antiepileptic activity of a new amide derivative of valproic acid and 1,3,4-thiadiazole.Materials and Methods: The antiepileptic activity of valprazolamide (N- (5-ethyl-1,3,4-thiadiazol-2-yl) -2-propylpentanamide) was tested in mice using the model of maximal ele...
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| Format: | Article |
| Language: | Russian |
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IRBIS LLC
2020-01-01
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| Series: | Эпилепсия и пароксизмальные состояния |
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| Online Access: | https://www.epilepsia.su/jour/article/view/501 |
| _version_ | 1797879365250318336 |
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| author | A. S. Malygin |
| author_facet | A. S. Malygin |
| author_sort | A. S. Malygin |
| collection | DOAJ |
| description | Aim – experimental evaluation of the antiepileptic activity of a new amide derivative of valproic acid and 1,3,4-thiadiazole.Materials and Methods: The antiepileptic activity of valprazolamide (N- (5-ethyl-1,3,4-thiadiazol-2-yl) -2-propylpentanamide) was tested in mice using the model of maximal electroshock and also the antagonism model with pentylenetetrazole. Neurotoxicity was assessed with the rotating rod test and the probit analysis. The therapeutic and protective index and the ED50 values were calculated for each experimental model of epilepsy.Results: The ED50 values of valprazolamide (intraperitoneally) in mice with seizures induced by pentylenetetrazole or maximal electroshock were 74.5 (46.8-106.4) mg/kg or 138.4 (97.2-197.2) mg/kg, respectively.Conclusion: The new amide derivative of valproic acid and 1,3,4-thiadiazole (valprazolamide) has an antiepileptic activity.The author declares no financial support or conflict of interest with respect to this publication. |
| first_indexed | 2024-04-10T02:47:35Z |
| format | Article |
| id | doaj.art-403bba13ae0344d985ad6ccb56c5747a |
| institution | Directory Open Access Journal |
| issn | 2077-8333 2311-4088 |
| language | Russian |
| last_indexed | 2024-04-10T02:47:35Z |
| publishDate | 2020-01-01 |
| publisher | IRBIS LLC |
| record_format | Article |
| series | Эпилепсия и пароксизмальные состояния |
| spelling | doaj.art-403bba13ae0344d985ad6ccb56c5747a2023-03-13T07:44:17ZrusIRBIS LLCЭпилепсия и пароксизмальные состояния2077-83332311-40882020-01-0111435736310.17749/2077-8333.2019.11.4.357-363467Study on the antiepyleptic activity of the new amide derivative of valproic acid and 1,3,4-thiadiazoleA. S. Malygin0Tver State Medical UniversityAim – experimental evaluation of the antiepileptic activity of a new amide derivative of valproic acid and 1,3,4-thiadiazole.Materials and Methods: The antiepileptic activity of valprazolamide (N- (5-ethyl-1,3,4-thiadiazol-2-yl) -2-propylpentanamide) was tested in mice using the model of maximal electroshock and also the antagonism model with pentylenetetrazole. Neurotoxicity was assessed with the rotating rod test and the probit analysis. The therapeutic and protective index and the ED50 values were calculated for each experimental model of epilepsy.Results: The ED50 values of valprazolamide (intraperitoneally) in mice with seizures induced by pentylenetetrazole or maximal electroshock were 74.5 (46.8-106.4) mg/kg or 138.4 (97.2-197.2) mg/kg, respectively.Conclusion: The new amide derivative of valproic acid and 1,3,4-thiadiazole (valprazolamide) has an antiepileptic activity.The author declares no financial support or conflict of interest with respect to this publication.https://www.epilepsia.su/jour/article/view/501antiepileptic drugsvalproic acidpentylenetetrazole-induced seizuresmaximal electroshock |
| spellingShingle | A. S. Malygin Study on the antiepyleptic activity of the new amide derivative of valproic acid and 1,3,4-thiadiazole Эпилепсия и пароксизмальные состояния antiepileptic drugs valproic acid pentylenetetrazole-induced seizures maximal electroshock |
| title | Study on the antiepyleptic activity of the new amide derivative of valproic acid and 1,3,4-thiadiazole |
| title_full | Study on the antiepyleptic activity of the new amide derivative of valproic acid and 1,3,4-thiadiazole |
| title_fullStr | Study on the antiepyleptic activity of the new amide derivative of valproic acid and 1,3,4-thiadiazole |
| title_full_unstemmed | Study on the antiepyleptic activity of the new amide derivative of valproic acid and 1,3,4-thiadiazole |
| title_short | Study on the antiepyleptic activity of the new amide derivative of valproic acid and 1,3,4-thiadiazole |
| title_sort | study on the antiepyleptic activity of the new amide derivative of valproic acid and 1 3 4 thiadiazole |
| topic | antiepileptic drugs valproic acid pentylenetetrazole-induced seizures maximal electroshock |
| url | https://www.epilepsia.su/jour/article/view/501 |
| work_keys_str_mv | AT asmalygin studyontheantiepylepticactivityofthenewamidederivativeofvalproicacidand134thiadiazole |