Conservation and Enhanced Binding of SARS-CoV-2 Omicron Spike Protein to Coreceptor Neuropilin-1 Predicted by Docking Analysis
The Omicron variant of SARS-CoV-2 bears peptide sequence alterations that correlate with a higher infectivity than was observed in the original SARS-CoV-2 isolated from Wuhan, China. We analyzed the CendR motif of spike protein and performed in silico molecular docking with neuropilin-1 (Nrp1), a re...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Infectious Disease Reports |
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| Online Access: | https://www.mdpi.com/2036-7449/14/2/29 |
| _version_ | 1797434551271686144 |
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| author | Piyush Baindara Dinata Roy Santi M. Mandal Adam G. Schrum |
| author_facet | Piyush Baindara Dinata Roy Santi M. Mandal Adam G. Schrum |
| author_sort | Piyush Baindara |
| collection | DOAJ |
| description | The Omicron variant of SARS-CoV-2 bears peptide sequence alterations that correlate with a higher infectivity than was observed in the original SARS-CoV-2 isolated from Wuhan, China. We analyzed the CendR motif of spike protein and performed in silico molecular docking with neuropilin-1 (Nrp1), a receptor–ligand interaction known to support infection by the original variant. Our analysis predicts conserved and slightly increased energetic favorability of binding for Omicron CendR:Nrp1. We propose that the viral spike:Nrp1 coreceptor pathway may contribute to the infectivity of the Omicron variant of SARS-CoV-2. |
| first_indexed | 2024-03-09T10:34:58Z |
| format | Article |
| id | doaj.art-403cc96dbe6341a4b385e227d3fc560c |
| institution | Directory Open Access Journal |
| issn | 2036-7449 |
| language | English |
| last_indexed | 2024-03-09T10:34:58Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Infectious Disease Reports |
| spelling | doaj.art-403cc96dbe6341a4b385e227d3fc560c2023-12-01T21:01:04ZengMDPI AGInfectious Disease Reports2036-74492022-03-0114224324910.3390/idr14020029Conservation and Enhanced Binding of SARS-CoV-2 Omicron Spike Protein to Coreceptor Neuropilin-1 Predicted by Docking AnalysisPiyush Baindara0Dinata Roy1Santi M. Mandal2Adam G. Schrum3Departments of Molecular Microbiology & Immunology, Surgery, and Biomedical, Biological, & Chemical Engineering, School of Medicine, College of Engineering, University of Missouri, Columbia, MO 65211, USADepartment of Zoology, Mizoram University, Aizawl 796004, Mizoram, IndiaCentral Research Facility, Indian Institute of Technology Kharagpur, Kharagpur 721302, West Bengal, IndiaDepartments of Molecular Microbiology & Immunology, Surgery, and Biomedical, Biological, & Chemical Engineering, School of Medicine, College of Engineering, University of Missouri, Columbia, MO 65211, USAThe Omicron variant of SARS-CoV-2 bears peptide sequence alterations that correlate with a higher infectivity than was observed in the original SARS-CoV-2 isolated from Wuhan, China. We analyzed the CendR motif of spike protein and performed in silico molecular docking with neuropilin-1 (Nrp1), a receptor–ligand interaction known to support infection by the original variant. Our analysis predicts conserved and slightly increased energetic favorability of binding for Omicron CendR:Nrp1. We propose that the viral spike:Nrp1 coreceptor pathway may contribute to the infectivity of the Omicron variant of SARS-CoV-2.https://www.mdpi.com/2036-7449/14/2/29SARS-CoV-2Omicronspike proteinneuropilin-1CendRCOVID-19 |
| spellingShingle | Piyush Baindara Dinata Roy Santi M. Mandal Adam G. Schrum Conservation and Enhanced Binding of SARS-CoV-2 Omicron Spike Protein to Coreceptor Neuropilin-1 Predicted by Docking Analysis Infectious Disease Reports SARS-CoV-2 Omicron spike protein neuropilin-1 CendR COVID-19 |
| title | Conservation and Enhanced Binding of SARS-CoV-2 Omicron Spike Protein to Coreceptor Neuropilin-1 Predicted by Docking Analysis |
| title_full | Conservation and Enhanced Binding of SARS-CoV-2 Omicron Spike Protein to Coreceptor Neuropilin-1 Predicted by Docking Analysis |
| title_fullStr | Conservation and Enhanced Binding of SARS-CoV-2 Omicron Spike Protein to Coreceptor Neuropilin-1 Predicted by Docking Analysis |
| title_full_unstemmed | Conservation and Enhanced Binding of SARS-CoV-2 Omicron Spike Protein to Coreceptor Neuropilin-1 Predicted by Docking Analysis |
| title_short | Conservation and Enhanced Binding of SARS-CoV-2 Omicron Spike Protein to Coreceptor Neuropilin-1 Predicted by Docking Analysis |
| title_sort | conservation and enhanced binding of sars cov 2 omicron spike protein to coreceptor neuropilin 1 predicted by docking analysis |
| topic | SARS-CoV-2 Omicron spike protein neuropilin-1 CendR COVID-19 |
| url | https://www.mdpi.com/2036-7449/14/2/29 |
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