Differentiated Thyroid Cancer in Children in the Last 20 Years: A Regional Study in Romania
Pediatric thyroid carcinoma is a current area of interest, because there are few studies in this field; the current classification and treatment guidelines are extrapolated from adults, sometimes leading to overly aggressive treatments or incomplete treatment of the disease. The purpose of this retr...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/9/11/3617 |
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| author | Andreea-Ioana Ștefan Andra Piciu Simona Sorana Căinap Katalin Gabora Doina Piciu |
| author_facet | Andreea-Ioana Ștefan Andra Piciu Simona Sorana Căinap Katalin Gabora Doina Piciu |
| author_sort | Andreea-Ioana Ștefan |
| collection | DOAJ |
| description | Pediatric thyroid carcinoma is a current area of interest, because there are few studies in this field; the current classification and treatment guidelines are extrapolated from adults, sometimes leading to overly aggressive treatments or incomplete treatment of the disease. The purpose of this retrospective study is to analyze the presentation, diagnosis, treatment, complications, and outcome of children diagnosed with thyroid cancer in the last two decades (2000–2018) at the Oncological Institute “Prof. Dr. Ion Chiricuță” Cluj-Napoca (IOCN) Romania, a tertiary center in a region with environmental influences from both the nuclear fallout of the Chernobyl accident and from iodine deficiency. The results were compared with those obtained in a previous study carried out in the same institution between 1991–2010, and with those obtained in a similar study carried out in Netherlands between 1970–2013, a cohort of children not exposed to the post-Chernobyl fallout. We statistically analyzed 62 patients. Papillary form was present in the majority of cases, and we highlighted the occurrence of thyroid microcarcinoma in children. A total of 85.4% of patients received radioiodine, the total activity being significantly lower compared with the data from literature. In our study, the prognosis of the disease was excellent, with 100% overall survival. |
| first_indexed | 2024-03-10T14:57:43Z |
| format | Article |
| id | doaj.art-403cd40f08334cd6987373dd3edc79b5 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T14:57:43Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-403cd40f08334cd6987373dd3edc79b52023-11-20T20:25:37ZengMDPI AGJournal of Clinical Medicine2077-03832020-11-01911361710.3390/jcm9113617Differentiated Thyroid Cancer in Children in the Last 20 Years: A Regional Study in RomaniaAndreea-Ioana Ștefan0Andra Piciu1Simona Sorana Căinap2Katalin Gabora3Doina Piciu4Doctoral School of Iuliu Hațieganu, University of Medicine and Pharmacy, 400012 Cluj-Napoca, RomaniaDepartment of Medical Oncology Iuliu Hațieganu, University of Medicine and Pharmacy, 400012 Cluj-Napoca, RomaniaDepartment of Mother and Child, “Iuliu Hațieganu”, University of Medicine and Pharmacy, 400177 Cluj-Napoca, RomaniaDoctoral School of Iuliu Hațieganu, University of Medicine and Pharmacy, 400012 Cluj-Napoca, RomaniaDoctoral School of Iuliu Hațieganu, University of Medicine and Pharmacy, 400012 Cluj-Napoca, RomaniaPediatric thyroid carcinoma is a current area of interest, because there are few studies in this field; the current classification and treatment guidelines are extrapolated from adults, sometimes leading to overly aggressive treatments or incomplete treatment of the disease. The purpose of this retrospective study is to analyze the presentation, diagnosis, treatment, complications, and outcome of children diagnosed with thyroid cancer in the last two decades (2000–2018) at the Oncological Institute “Prof. Dr. Ion Chiricuță” Cluj-Napoca (IOCN) Romania, a tertiary center in a region with environmental influences from both the nuclear fallout of the Chernobyl accident and from iodine deficiency. The results were compared with those obtained in a previous study carried out in the same institution between 1991–2010, and with those obtained in a similar study carried out in Netherlands between 1970–2013, a cohort of children not exposed to the post-Chernobyl fallout. We statistically analyzed 62 patients. Papillary form was present in the majority of cases, and we highlighted the occurrence of thyroid microcarcinoma in children. A total of 85.4% of patients received radioiodine, the total activity being significantly lower compared with the data from literature. In our study, the prognosis of the disease was excellent, with 100% overall survival.https://www.mdpi.com/2077-0383/9/11/3617pediatric differentiated thyroid cancer |
| spellingShingle | Andreea-Ioana Ștefan Andra Piciu Simona Sorana Căinap Katalin Gabora Doina Piciu Differentiated Thyroid Cancer in Children in the Last 20 Years: A Regional Study in Romania Journal of Clinical Medicine pediatric differentiated thyroid cancer |
| title | Differentiated Thyroid Cancer in Children in the Last 20 Years: A Regional Study in Romania |
| title_full | Differentiated Thyroid Cancer in Children in the Last 20 Years: A Regional Study in Romania |
| title_fullStr | Differentiated Thyroid Cancer in Children in the Last 20 Years: A Regional Study in Romania |
| title_full_unstemmed | Differentiated Thyroid Cancer in Children in the Last 20 Years: A Regional Study in Romania |
| title_short | Differentiated Thyroid Cancer in Children in the Last 20 Years: A Regional Study in Romania |
| title_sort | differentiated thyroid cancer in children in the last 20 years a regional study in romania |
| topic | pediatric differentiated thyroid cancer |
| url | https://www.mdpi.com/2077-0383/9/11/3617 |
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