Enhancing myocardial function with cardiac contractility modulation: potential and challenges
Abstract Cardiac contractility modulation (CCM) offers a novel therapeutic avenue for heart failure patients, particularly those unresponsive to cardiac resynchronization therapy within specific QRS duration ranges. This review elucidates CCM's mechanistic underpinnings, its impact on myocardia...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-02-01
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| Series: | ESC Heart Failure |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ehf2.14575 |
| _version_ | 1797348413667278848 |
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| author | Zihan Li Qiming Liu Shenghua Zhou Yichao Xiao |
| author_facet | Zihan Li Qiming Liu Shenghua Zhou Yichao Xiao |
| author_sort | Zihan Li |
| collection | DOAJ |
| description | Abstract Cardiac contractility modulation (CCM) offers a novel therapeutic avenue for heart failure patients, particularly those unresponsive to cardiac resynchronization therapy within specific QRS duration ranges. This review elucidates CCM's mechanistic underpinnings, its impact on myocardial function, and utility across patient demographics. However, CCM is limited by insufficient data on mortality and hospitalization rate reductions, as well as the need for specialized device implantation skills. While prevailing research has concentrated on left ventricular effects, a knowledge gap persists for other patient subsets. Future inquiries should address combinatory treatment strategies, extended usage and the impact of atrial fibrillation on device implantation. Such expanded studies could refine therapeutic outcomes and widen the scope of beneficiaries. |
| first_indexed | 2024-03-08T12:05:32Z |
| format | Article |
| id | doaj.art-403cec2d4c604e9fb32778b1f468bdc0 |
| institution | Directory Open Access Journal |
| issn | 2055-5822 |
| language | English |
| last_indexed | 2024-03-08T12:05:32Z |
| publishDate | 2024-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | ESC Heart Failure |
| spelling | doaj.art-403cec2d4c604e9fb32778b1f468bdc02024-01-23T08:40:25ZengWileyESC Heart Failure2055-58222024-02-0111111210.1002/ehf2.14575Enhancing myocardial function with cardiac contractility modulation: potential and challengesZihan Li0Qiming Liu1Shenghua Zhou2Yichao Xiao3Department of Cardiovascular Medicine, Second Xiangya Hospital Central South University Changsha ChinaDepartment of Cardiovascular Medicine, Second Xiangya Hospital Central South University Changsha ChinaDepartment of Cardiovascular Medicine, Second Xiangya Hospital Central South University Changsha ChinaDepartment of Cardiovascular Medicine, Second Xiangya Hospital Central South University Changsha ChinaAbstract Cardiac contractility modulation (CCM) offers a novel therapeutic avenue for heart failure patients, particularly those unresponsive to cardiac resynchronization therapy within specific QRS duration ranges. This review elucidates CCM's mechanistic underpinnings, its impact on myocardial function, and utility across patient demographics. However, CCM is limited by insufficient data on mortality and hospitalization rate reductions, as well as the need for specialized device implantation skills. While prevailing research has concentrated on left ventricular effects, a knowledge gap persists for other patient subsets. Future inquiries should address combinatory treatment strategies, extended usage and the impact of atrial fibrillation on device implantation. Such expanded studies could refine therapeutic outcomes and widen the scope of beneficiaries.https://doi.org/10.1002/ehf2.14575Cardiac contractility modulationCardiac devicesDevice implantationHeart failure |
| spellingShingle | Zihan Li Qiming Liu Shenghua Zhou Yichao Xiao Enhancing myocardial function with cardiac contractility modulation: potential and challenges ESC Heart Failure Cardiac contractility modulation Cardiac devices Device implantation Heart failure |
| title | Enhancing myocardial function with cardiac contractility modulation: potential and challenges |
| title_full | Enhancing myocardial function with cardiac contractility modulation: potential and challenges |
| title_fullStr | Enhancing myocardial function with cardiac contractility modulation: potential and challenges |
| title_full_unstemmed | Enhancing myocardial function with cardiac contractility modulation: potential and challenges |
| title_short | Enhancing myocardial function with cardiac contractility modulation: potential and challenges |
| title_sort | enhancing myocardial function with cardiac contractility modulation potential and challenges |
| topic | Cardiac contractility modulation Cardiac devices Device implantation Heart failure |
| url | https://doi.org/10.1002/ehf2.14575 |
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