Global cognitive function correlates with P‐wave dispersion in frail hypertensive older adults
Abstract P‐Wave Dispersion (PWD) is an ECG parameter defined as the difference between the longest and the shortest P‐Wave duration. PWD has been associated with hypertension, a leading cause of age‐related cognitive decline. Moreover, hypertension is associated with vascular dementia and Alzheimer&...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-05-01
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| Series: | The Journal of Clinical Hypertension |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/jch.14439 |
| _version_ | 1797645152186007552 |
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| author | Pasquale Mone Antonella Pansini Francesco Calabrò Stefano De Gennaro Mafalda Esposito Paolo Rinaldi Antonio Colin Fabio Minicucci Antonio Coppola Salvatore Frullone Gaetano Santulli |
| author_facet | Pasquale Mone Antonella Pansini Francesco Calabrò Stefano De Gennaro Mafalda Esposito Paolo Rinaldi Antonio Colin Fabio Minicucci Antonio Coppola Salvatore Frullone Gaetano Santulli |
| author_sort | Pasquale Mone |
| collection | DOAJ |
| description | Abstract P‐Wave Dispersion (PWD) is an ECG parameter defined as the difference between the longest and the shortest P‐Wave duration. PWD has been associated with hypertension, a leading cause of age‐related cognitive decline. Moreover, hypertension is associated with vascular dementia and Alzheimer's Disease. Based on these considerations, we evaluated PWD and global cognitive function in frail hypertensive older adults with a previous diagnosis of cognitive decline. We evaluated consecutive frail hypertensive patients ≥65‐year‐old with a Mini‐Mental State Examination (MMSE) score <26. Patients with evidence of secondary hypertension, history of stroke, myocardial infarction, or therapy with beta‐blockers or acetylcholinesterase inhibitors were excluded. Beta‐blocker therapy causes a significant decrease in PWD; patients treated with acetylcholinesterase inhibitors were not included to avoid confounding effects on cognitive function. By examining 180 patients, we found that PWD significantly correlated with MMSE score. Strikingly, these effects were confirmed in a linear multivariate analysis with a regression model. To our knowledge, this is the first study showing that PWD correlates with global cognitive function in frail hypertensive older adults. |
| first_indexed | 2024-03-11T14:41:59Z |
| format | Article |
| id | doaj.art-404291485fb34bb6b17ddc8f50dec0f3 |
| institution | Directory Open Access Journal |
| issn | 1524-6175 1751-7176 |
| language | English |
| last_indexed | 2024-03-11T14:41:59Z |
| publishDate | 2022-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Journal of Clinical Hypertension |
| spelling | doaj.art-404291485fb34bb6b17ddc8f50dec0f32023-10-30T13:26:49ZengWileyThe Journal of Clinical Hypertension1524-61751751-71762022-05-0124563864310.1111/jch.14439Global cognitive function correlates with P‐wave dispersion in frail hypertensive older adultsPasquale Mone0Antonella Pansini1Francesco Calabrò2Stefano De Gennaro3Mafalda Esposito4Paolo Rinaldi5Antonio Colin6Fabio Minicucci7Antonio Coppola8Salvatore Frullone9Gaetano Santulli10Department of Medicine, Division of Cardiology Wilf Family Cardiovascular Research Institute, Einstein Institute for Aging Research Albert Einstein College of Medicine New York City NY USAASL Avellino Avellino ItalyUniversity of Naples “Federico II” Naples ItalyASL Naples Naples ItalyASL Naples Naples ItalyASL Naples Naples ItalyASL Naples Naples ItalyASL Naples Naples ItalyASL Naples Naples ItalyASL Avellino Avellino ItalyDepartment of Medicine, Division of Cardiology Wilf Family Cardiovascular Research Institute, Einstein Institute for Aging Research Albert Einstein College of Medicine New York City NY USAAbstract P‐Wave Dispersion (PWD) is an ECG parameter defined as the difference between the longest and the shortest P‐Wave duration. PWD has been associated with hypertension, a leading cause of age‐related cognitive decline. Moreover, hypertension is associated with vascular dementia and Alzheimer's Disease. Based on these considerations, we evaluated PWD and global cognitive function in frail hypertensive older adults with a previous diagnosis of cognitive decline. We evaluated consecutive frail hypertensive patients ≥65‐year‐old with a Mini‐Mental State Examination (MMSE) score <26. Patients with evidence of secondary hypertension, history of stroke, myocardial infarction, or therapy with beta‐blockers or acetylcholinesterase inhibitors were excluded. Beta‐blocker therapy causes a significant decrease in PWD; patients treated with acetylcholinesterase inhibitors were not included to avoid confounding effects on cognitive function. By examining 180 patients, we found that PWD significantly correlated with MMSE score. Strikingly, these effects were confirmed in a linear multivariate analysis with a regression model. To our knowledge, this is the first study showing that PWD correlates with global cognitive function in frail hypertensive older adults.https://doi.org/10.1111/jch.14439cognitive functionECGfrailtyhypertensionolder adults |
| spellingShingle | Pasquale Mone Antonella Pansini Francesco Calabrò Stefano De Gennaro Mafalda Esposito Paolo Rinaldi Antonio Colin Fabio Minicucci Antonio Coppola Salvatore Frullone Gaetano Santulli Global cognitive function correlates with P‐wave dispersion in frail hypertensive older adults The Journal of Clinical Hypertension cognitive function ECG frailty hypertension older adults |
| title | Global cognitive function correlates with P‐wave dispersion in frail hypertensive older adults |
| title_full | Global cognitive function correlates with P‐wave dispersion in frail hypertensive older adults |
| title_fullStr | Global cognitive function correlates with P‐wave dispersion in frail hypertensive older adults |
| title_full_unstemmed | Global cognitive function correlates with P‐wave dispersion in frail hypertensive older adults |
| title_short | Global cognitive function correlates with P‐wave dispersion in frail hypertensive older adults |
| title_sort | global cognitive function correlates with p wave dispersion in frail hypertensive older adults |
| topic | cognitive function ECG frailty hypertension older adults |
| url | https://doi.org/10.1111/jch.14439 |
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