Indispensable role of immunophenotyping in diagnosing leukemic phase of blastic plasmacytoid dendritic cell neoplasm without cutaneous manifestation
Blastic plasmacytoid dendritic cell neoplasm usually presents as skin lesions. Diagnostic error occurs when it primarily presents in leukemic phase without skin involvement. Triad of CD4, CD56 and CD123 immunophenotype expression is essential to avoid misdiagnosis of this rare hematological malignan...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | Leukemia Research Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213048922000292 |
| _version_ | 1828331989986443264 |
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| author | Hareem Alam Nabiha Saeed Anila Rashid |
| author_facet | Hareem Alam Nabiha Saeed Anila Rashid |
| author_sort | Hareem Alam |
| collection | DOAJ |
| description | Blastic plasmacytoid dendritic cell neoplasm usually presents as skin lesions. Diagnostic error occurs when it primarily presents in leukemic phase without skin involvement. Triad of CD4, CD56 and CD123 immunophenotype expression is essential to avoid misdiagnosis of this rare hematological malignancy. Here we describe a patient who presented in overt leukemic phase of BPDCN highlighting diagnostic challenges encountered that resulted in delayed diagnosis and poor outcome. |
| first_indexed | 2024-04-13T20:59:42Z |
| format | Article |
| id | doaj.art-4044bc02a19c409184144aa63bbf63e1 |
| institution | Directory Open Access Journal |
| issn | 2213-0489 |
| language | English |
| last_indexed | 2024-04-13T20:59:42Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Leukemia Research Reports |
| spelling | doaj.art-4044bc02a19c409184144aa63bbf63e12022-12-22T02:30:10ZengElsevierLeukemia Research Reports2213-04892022-01-0117100317Indispensable role of immunophenotyping in diagnosing leukemic phase of blastic plasmacytoid dendritic cell neoplasm without cutaneous manifestationHareem Alam0Nabiha Saeed1Anila Rashid2Section of Hematology & Transfusion Medicine, Department of Pathology and Laboratory Medicine, Aga Khan University Hospital, Karachi, PakistanDepartment of Oncology, Aga Khan University Hospital, Karachi, PakistanSection of Hematology & Transfusion Medicine, Department of Pathology and Laboratory Medicine, Aga Khan University Hospital, Karachi, Pakistan; Corresponding author.Blastic plasmacytoid dendritic cell neoplasm usually presents as skin lesions. Diagnostic error occurs when it primarily presents in leukemic phase without skin involvement. Triad of CD4, CD56 and CD123 immunophenotype expression is essential to avoid misdiagnosis of this rare hematological malignancy. Here we describe a patient who presented in overt leukemic phase of BPDCN highlighting diagnostic challenges encountered that resulted in delayed diagnosis and poor outcome.http://www.sciencedirect.com/science/article/pii/S2213048922000292Blastic plasmacytoid dendritic cell neoplasmPlasmacytoid dendritic cellsLeukemiaImmunophenotypingFlowcytometry |
| spellingShingle | Hareem Alam Nabiha Saeed Anila Rashid Indispensable role of immunophenotyping in diagnosing leukemic phase of blastic plasmacytoid dendritic cell neoplasm without cutaneous manifestation Leukemia Research Reports Blastic plasmacytoid dendritic cell neoplasm Plasmacytoid dendritic cells Leukemia Immunophenotyping Flowcytometry |
| title | Indispensable role of immunophenotyping in diagnosing leukemic phase of blastic plasmacytoid dendritic cell neoplasm without cutaneous manifestation |
| title_full | Indispensable role of immunophenotyping in diagnosing leukemic phase of blastic plasmacytoid dendritic cell neoplasm without cutaneous manifestation |
| title_fullStr | Indispensable role of immunophenotyping in diagnosing leukemic phase of blastic plasmacytoid dendritic cell neoplasm without cutaneous manifestation |
| title_full_unstemmed | Indispensable role of immunophenotyping in diagnosing leukemic phase of blastic plasmacytoid dendritic cell neoplasm without cutaneous manifestation |
| title_short | Indispensable role of immunophenotyping in diagnosing leukemic phase of blastic plasmacytoid dendritic cell neoplasm without cutaneous manifestation |
| title_sort | indispensable role of immunophenotyping in diagnosing leukemic phase of blastic plasmacytoid dendritic cell neoplasm without cutaneous manifestation |
| topic | Blastic plasmacytoid dendritic cell neoplasm Plasmacytoid dendritic cells Leukemia Immunophenotyping Flowcytometry |
| url | http://www.sciencedirect.com/science/article/pii/S2213048922000292 |
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