Thyroid Cancer and Psoriasis: A Nested Case–Control Study
Previous researchers have suggested an elevated risk of thyroid cancer (TC) in patients with psoriasis with mixed results. The current study evaluated the relationship of psoriasis with the risk of TC in an adult population. The data from the Korean National Health Insurance Service—Health Screening...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-09-01
|
| Series: | Diagnostics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4418/12/10/2297 |
| _version_ | 1797473895279755264 |
|---|---|
| author | So Young Kim Dae Myoung Yoo Juyong Chung Hyo Geun Choi |
| author_facet | So Young Kim Dae Myoung Yoo Juyong Chung Hyo Geun Choi |
| author_sort | So Young Kim |
| collection | DOAJ |
| description | Previous researchers have suggested an elevated risk of thyroid cancer (TC) in patients with psoriasis with mixed results. The current study evaluated the relationship of psoriasis with the risk of TC in an adult population. The data from the Korean National Health Insurance Service—Health Screening Cohort ≥ 40 years old were analyzed. In total, 6822 patients with TC were equalized with 27,288 control participants using overlap weighting adjustment based on the propensity score. The history of psoriasis was compared between the TC and control groups using multivariable logistic regression analysis. Secondary analyses were conducted according to age, sex, income, region of residence, systolic blood pressure, diastolic blood pressure, fasting blood glucose, total cholesterol, obesity, smoking, alcohol consumption, the Charlson Comorbidity Index scores, hypothyroidism, goiter, thyrotoxicosis, and thyroiditis. The history of psoriasis was not different in patients with TC (overlap-weighted odds ratio (OR) = 1.02, 95% confidence intervals (CI) = 0.85–1.22). The <55-year-old group showed a high rate of TC associated with psoriasis (overlap-weighted OR = 1.69, 95% CI = 1.22–2.36, <i>p</i> = 0.002). The population without hypothyroidism demonstrated an increased rate of TC related to psoriasis (overlap-weighted OR = 1.29, 95% CI = 1.06–1.57, <i>p</i> = 0.012). The patients with hypothyroidism showed a low rate of TC for psoriasis (overlap-weighted OR = 0.59, 95% CI = 0.37–0.96, <i>p</i> = 0.034). None of the other subgroups showed an association between psoriasis and TC. Psoriasis was not related to the risk of TC in the overall adult population. Young adults and populations without hypothyroidism indicated an elevated rate of TC for psoriasis. |
| first_indexed | 2024-03-09T20:23:10Z |
| format | Article |
| id | doaj.art-4044bc21721b4808855c8b061238d25e |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-09T20:23:10Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-4044bc21721b4808855c8b061238d25e2023-11-23T23:42:50ZengMDPI AGDiagnostics2075-44182022-09-011210229710.3390/diagnostics12102297Thyroid Cancer and Psoriasis: A Nested Case–Control StudySo Young Kim0Dae Myoung Yoo1Juyong Chung2Hyo Geun Choi3Bundang CHA Medical Center, Department of Otorhinolaryngology-Head and Neck Surgery, CHA University, Seongnam 13488, KoreaHallym Data Science Laboratory, Hallym University College of Medicine, Anyang 14066, KoreaDepartment of Otorhinolaryngology-Head and Neck Surgery, Wonkwang University School of Medicine, Iksan 54538, KoreaHallym Data Science Laboratory, Hallym University College of Medicine, Anyang 14066, KoreaPrevious researchers have suggested an elevated risk of thyroid cancer (TC) in patients with psoriasis with mixed results. The current study evaluated the relationship of psoriasis with the risk of TC in an adult population. The data from the Korean National Health Insurance Service—Health Screening Cohort ≥ 40 years old were analyzed. In total, 6822 patients with TC were equalized with 27,288 control participants using overlap weighting adjustment based on the propensity score. The history of psoriasis was compared between the TC and control groups using multivariable logistic regression analysis. Secondary analyses were conducted according to age, sex, income, region of residence, systolic blood pressure, diastolic blood pressure, fasting blood glucose, total cholesterol, obesity, smoking, alcohol consumption, the Charlson Comorbidity Index scores, hypothyroidism, goiter, thyrotoxicosis, and thyroiditis. The history of psoriasis was not different in patients with TC (overlap-weighted odds ratio (OR) = 1.02, 95% confidence intervals (CI) = 0.85–1.22). The <55-year-old group showed a high rate of TC associated with psoriasis (overlap-weighted OR = 1.69, 95% CI = 1.22–2.36, <i>p</i> = 0.002). The population without hypothyroidism demonstrated an increased rate of TC related to psoriasis (overlap-weighted OR = 1.29, 95% CI = 1.06–1.57, <i>p</i> = 0.012). The patients with hypothyroidism showed a low rate of TC for psoriasis (overlap-weighted OR = 0.59, 95% CI = 0.37–0.96, <i>p</i> = 0.034). None of the other subgroups showed an association between psoriasis and TC. Psoriasis was not related to the risk of TC in the overall adult population. Young adults and populations without hypothyroidism indicated an elevated rate of TC for psoriasis.https://www.mdpi.com/2075-4418/12/10/2297thyroid cancerpsoriasisrisk factorscohort studies |
| spellingShingle | So Young Kim Dae Myoung Yoo Juyong Chung Hyo Geun Choi Thyroid Cancer and Psoriasis: A Nested Case–Control Study Diagnostics thyroid cancer psoriasis risk factors cohort studies |
| title | Thyroid Cancer and Psoriasis: A Nested Case–Control Study |
| title_full | Thyroid Cancer and Psoriasis: A Nested Case–Control Study |
| title_fullStr | Thyroid Cancer and Psoriasis: A Nested Case–Control Study |
| title_full_unstemmed | Thyroid Cancer and Psoriasis: A Nested Case–Control Study |
| title_short | Thyroid Cancer and Psoriasis: A Nested Case–Control Study |
| title_sort | thyroid cancer and psoriasis a nested case control study |
| topic | thyroid cancer psoriasis risk factors cohort studies |
| url | https://www.mdpi.com/2075-4418/12/10/2297 |
| work_keys_str_mv | AT soyoungkim thyroidcancerandpsoriasisanestedcasecontrolstudy AT daemyoungyoo thyroidcancerandpsoriasisanestedcasecontrolstudy AT juyongchung thyroidcancerandpsoriasisanestedcasecontrolstudy AT hyogeunchoi thyroidcancerandpsoriasisanestedcasecontrolstudy |