Influence of Renal Impairment and Genetic Subtypes on Warfarin Control in Japanese Patients

Influence of Renal Impairment and Genetic Subtypes on Warfarin Control in Japanese Patients

The genotypes of vitamin K epoxide reductase complex 1 (<i>VKORC1</i>) and cytochrome P450 2C9 (<i>CYP2C9</i>) can influence therapeutic warfarin doses. Conversely, nongenetic factors, especially renal function, are associated with warfarin maintenance doses; however, the opt...

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Bibliographic Details
Main Authors: Tomotaka Tanaka, Masafumi Ihara, Kazuki Fukuma, Haruko Yamamoto, Kazuo Washida, Shunsuke Kimura, Akiko Kada, Shigeki Miyata, Toshiyuki Miyata, Kazuyuki Nagatsuka
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Genes
Subjects:
warfarin
pharmacogenetics
dosing algorithm
renal impairment
<i>CYP2C9</i>
<i>VKORC1</i>
Online Access:https://www.mdpi.com/2073-4425/12/10/1537

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