A systematic review on the impact of gastrointestinal microbiota composition and function on cognition in healthy infants and children
Evidence from animal models or children with neurodevelopmental disorders has implicated the gut microbiome (GM) in neurocognitive development. However, even subclinical impairement of cognition can have negative consequences, as cognition serves as the foundation for skills necessary to succeed in...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2023.1171970/full |
| _version_ | 1827926387787300864 |
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| author | Arden L. McMath Miriam Aguilar-Lopez Miriam Aguilar-Lopez Corinne N. Cannavale Naiman A. Khan Naiman A. Khan Naiman A. Khan Naiman A. Khan Sharon M. Donovan Sharon M. Donovan |
| author_facet | Arden L. McMath Miriam Aguilar-Lopez Miriam Aguilar-Lopez Corinne N. Cannavale Naiman A. Khan Naiman A. Khan Naiman A. Khan Naiman A. Khan Sharon M. Donovan Sharon M. Donovan |
| author_sort | Arden L. McMath |
| collection | DOAJ |
| description | Evidence from animal models or children with neurodevelopmental disorders has implicated the gut microbiome (GM) in neurocognitive development. However, even subclinical impairement of cognition can have negative consequences, as cognition serves as the foundation for skills necessary to succeed in school, vocation and socially. The present study aims to identify gut microbiome characteristics or changes in gut microbiome characteristics that consistently associate with cognitive outcomes in healthy, neurotypical infants and children. Of the 1,520 articles identified in the search, 23 were included in qualitative synthesis after applying exclusion criteria. Most studies were cross-sectional and focused on behavior or motor and language skills. Bifidobacterium, Bacteroides, Clostridia, Prevotella, and Roseburia were related to these aspects of cognition across several studies. While these results support the role of GM in cognitive development, higher quality studies focused on more complex cognition are needed to understand the extent to which the GM contributes to cognitive development. |
| first_indexed | 2024-03-13T05:37:23Z |
| format | Article |
| id | doaj.art-4047b6fdb44b448f9b82f6c4da0cd968 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-03-13T05:37:23Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-4047b6fdb44b448f9b82f6c4da0cd9682023-06-14T05:19:13ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2023-06-011710.3389/fnins.2023.11719701171970A systematic review on the impact of gastrointestinal microbiota composition and function on cognition in healthy infants and childrenArden L. McMath0Miriam Aguilar-Lopez1Miriam Aguilar-Lopez2Corinne N. Cannavale3Naiman A. Khan4Naiman A. Khan5Naiman A. Khan6Naiman A. Khan7Sharon M. Donovan8Sharon M. Donovan9Division of Nutritional Sciences, University of Illinois Urbana-Champaign, Urbana, IL, United StatesDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, TX, United StatesTexas Children’s Microbiome Center, Department of Pathology, Texas Children’s Hospital, Houston, TX, United StatesDepartment of Kinesiology and Community Health, University of Illinois Urbana-Champaign, Urbana, IL, United StatesDivision of Nutritional Sciences, University of Illinois Urbana-Champaign, Urbana, IL, United StatesDepartment of Kinesiology and Community Health, University of Illinois Urbana-Champaign, Urbana, IL, United StatesNeuroscience Program, University of Illinois Urbana-Champaign, Champaign, IL, United StatesBeckman Institute for Advanced Science and Technology, University of Illinois Urbana-Champaign, Champaign, IL, United StatesDivision of Nutritional Sciences, University of Illinois Urbana-Champaign, Urbana, IL, United StatesDepartment of Food Science and Human Nutrition, University of Illinois Urbana-Champaign, Urbana, IL, United StatesEvidence from animal models or children with neurodevelopmental disorders has implicated the gut microbiome (GM) in neurocognitive development. However, even subclinical impairement of cognition can have negative consequences, as cognition serves as the foundation for skills necessary to succeed in school, vocation and socially. The present study aims to identify gut microbiome characteristics or changes in gut microbiome characteristics that consistently associate with cognitive outcomes in healthy, neurotypical infants and children. Of the 1,520 articles identified in the search, 23 were included in qualitative synthesis after applying exclusion criteria. Most studies were cross-sectional and focused on behavior or motor and language skills. Bifidobacterium, Bacteroides, Clostridia, Prevotella, and Roseburia were related to these aspects of cognition across several studies. While these results support the role of GM in cognitive development, higher quality studies focused on more complex cognition are needed to understand the extent to which the GM contributes to cognitive development.https://www.frontiersin.org/articles/10.3389/fnins.2023.1171970/fullgut microbiomeinfancychildhoodbehaviorcognition |
| spellingShingle | Arden L. McMath Miriam Aguilar-Lopez Miriam Aguilar-Lopez Corinne N. Cannavale Naiman A. Khan Naiman A. Khan Naiman A. Khan Naiman A. Khan Sharon M. Donovan Sharon M. Donovan A systematic review on the impact of gastrointestinal microbiota composition and function on cognition in healthy infants and children Frontiers in Neuroscience gut microbiome infancy childhood behavior cognition |
| title | A systematic review on the impact of gastrointestinal microbiota composition and function on cognition in healthy infants and children |
| title_full | A systematic review on the impact of gastrointestinal microbiota composition and function on cognition in healthy infants and children |
| title_fullStr | A systematic review on the impact of gastrointestinal microbiota composition and function on cognition in healthy infants and children |
| title_full_unstemmed | A systematic review on the impact of gastrointestinal microbiota composition and function on cognition in healthy infants and children |
| title_short | A systematic review on the impact of gastrointestinal microbiota composition and function on cognition in healthy infants and children |
| title_sort | systematic review on the impact of gastrointestinal microbiota composition and function on cognition in healthy infants and children |
| topic | gut microbiome infancy childhood behavior cognition |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2023.1171970/full |
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