NeuroEPO influence on the fetal heart in a placental insufficiency model of rats
<strong>Foundation:</strong> placental insufficiency is the most common cause of intrauterine growth retardation, which can cause cardiovascular alterations. Recently, erythropoietin therapies have been developed that protect hypoxic cardiac tissues.<br /><strong>Objective:&l...
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| Format: | Article |
| Language: | Spanish |
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Centro Provincial de Información de Ciencias Médicas. Cienfuegos
2024-02-01
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| Series: | Medisur |
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| Online Access: | http://medisur.sld.cu/index.php/medisur/article/view/6125 |
| _version_ | 1797277628714975232 |
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| author | Nìnive Nùñez Lòpez Julito Dos Santos Dos Santos Aida María Suàrez Aguiar María Antonia Cruz García Claudia Joffre Frías Carmen Inés Morales Paneque Laura López Marín |
| author_facet | Nìnive Nùñez Lòpez Julito Dos Santos Dos Santos Aida María Suàrez Aguiar María Antonia Cruz García Claudia Joffre Frías Carmen Inés Morales Paneque Laura López Marín |
| author_sort | Nìnive Nùñez Lòpez |
| collection | DOAJ |
| description | <strong>Foundation:</strong> placental insufficiency is the most common cause of intrauterine growth retardation, which can cause cardiovascular alterations. Recently, erythropoietin therapies have been developed that protect hypoxic cardiac tissues.<br /><strong>Objective:</strong> To evaluate the influence of human recombinant erythropoietin with low sialic acid content (NeuroEPO) on the fetal heart in a rat model of placental insufficiency.<br /><strong>Methods:</strong> 14 Wistar rats gestated with unilateral ligation of the right uterine artery on day 16 of gestation were used. That same day, seven rats were administered NeuroEPO (0.5 mg/kg/day subcutaneously for three days) and the rest received placebo. On day 20 of gestation, the fetuses were divided into four groups: a control group, a group with intrauterine growth retardation, a NeuroEPO control group, and a group with intrauterine growth retardation and NeuroEPO. In the fetuses, placental weight, fetal weight and placental efficiency were obtained. In the histological study, the number of cardiomyocytes, number of blood vessels and quantity of collagen fibers were quantified.<br /><strong>Results:</strong> the group with intrauterine growth retardation presented a decrease in fetal weight, the number of cardiomyocytes, the number of blood vessels and an increase in the amount of collagen fibers (p<0.05). When fetuses with intrauterine growth retardation were treated with NeuroEPO, fetal weight increased, although the weight was not similar to the control. The rest of the variables behaved similar to the control.<br /><strong>Conclusions:</strong> the administration of this molecule improved fetal weight and allowed an adequate balance in the development of the fetal heart, perhaps due to the cytoprotective effects of this molecule. |
| first_indexed | 2024-03-07T15:52:08Z |
| format | Article |
| id | doaj.art-4047fabdfe6c4e56b6fddf092c1bfd3c |
| institution | Directory Open Access Journal |
| issn | 1727-897X |
| language | Spanish |
| last_indexed | 2024-03-07T15:52:08Z |
| publishDate | 2024-02-01 |
| publisher | Centro Provincial de Información de Ciencias Médicas. Cienfuegos |
| record_format | Article |
| series | Medisur |
| spelling | doaj.art-4047fabdfe6c4e56b6fddf092c1bfd3c2024-03-04T23:09:56ZspaCentro Provincial de Información de Ciencias Médicas. CienfuegosMedisur1727-897X2024-02-012211271372471NeuroEPO influence on the fetal heart in a placental insufficiency model of ratsNìnive Nùñez Lòpez0Julito Dos Santos Dos Santos1Aida María Suàrez Aguiar2María Antonia Cruz García3Claudia Joffre Frías4Carmen Inés Morales Paneque5Laura López Marín6Universidad de Ciencias Médicas de La Habana. ICBP Victoria de Girón. La Habana. Cuba.Universidad Nacional Timor Lorosa´e (untl). Facultad de Medicina e Ciência da Saúde. Angola.Universidad de Ciencias Médicas de La Habana. ICBP Victoria de Girón. La Habana. Cuba.Universidad de Ciencias Médicas de La Habana. ICBP Victoria de Girón. La Habana. Cuba.Universidad de Ciencias Médicas de La Habana. ICBP Victoria de Girón. La Habana. Cuba.Universidad de Ciencias Médicas de La Habana. ICBP Victoria de Girón. La Habana. Cuba.Instituto de Nefrología. La Habana. Cuba.<strong>Foundation:</strong> placental insufficiency is the most common cause of intrauterine growth retardation, which can cause cardiovascular alterations. Recently, erythropoietin therapies have been developed that protect hypoxic cardiac tissues.<br /><strong>Objective:</strong> To evaluate the influence of human recombinant erythropoietin with low sialic acid content (NeuroEPO) on the fetal heart in a rat model of placental insufficiency.<br /><strong>Methods:</strong> 14 Wistar rats gestated with unilateral ligation of the right uterine artery on day 16 of gestation were used. That same day, seven rats were administered NeuroEPO (0.5 mg/kg/day subcutaneously for three days) and the rest received placebo. On day 20 of gestation, the fetuses were divided into four groups: a control group, a group with intrauterine growth retardation, a NeuroEPO control group, and a group with intrauterine growth retardation and NeuroEPO. In the fetuses, placental weight, fetal weight and placental efficiency were obtained. In the histological study, the number of cardiomyocytes, number of blood vessels and quantity of collagen fibers were quantified.<br /><strong>Results:</strong> the group with intrauterine growth retardation presented a decrease in fetal weight, the number of cardiomyocytes, the number of blood vessels and an increase in the amount of collagen fibers (p<0.05). When fetuses with intrauterine growth retardation were treated with NeuroEPO, fetal weight increased, although the weight was not similar to the control. The rest of the variables behaved similar to the control.<br /><strong>Conclusions:</strong> the administration of this molecule improved fetal weight and allowed an adequate balance in the development of the fetal heart, perhaps due to the cytoprotective effects of this molecule.http://medisur.sld.cu/index.php/medisur/article/view/6125hipoxia fetalcorazón fetalinsuficiencia placentariaeritropoeitina |
| spellingShingle | Nìnive Nùñez Lòpez Julito Dos Santos Dos Santos Aida María Suàrez Aguiar María Antonia Cruz García Claudia Joffre Frías Carmen Inés Morales Paneque Laura López Marín NeuroEPO influence on the fetal heart in a placental insufficiency model of rats Medisur hipoxia fetal corazón fetal insuficiencia placentaria eritropoeitina |
| title | NeuroEPO influence on the fetal heart in a placental insufficiency model of rats |
| title_full | NeuroEPO influence on the fetal heart in a placental insufficiency model of rats |
| title_fullStr | NeuroEPO influence on the fetal heart in a placental insufficiency model of rats |
| title_full_unstemmed | NeuroEPO influence on the fetal heart in a placental insufficiency model of rats |
| title_short | NeuroEPO influence on the fetal heart in a placental insufficiency model of rats |
| title_sort | neuroepo influence on the fetal heart in a placental insufficiency model of rats |
| topic | hipoxia fetal corazón fetal insuficiencia placentaria eritropoeitina |
| url | http://medisur.sld.cu/index.php/medisur/article/view/6125 |
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