Association between niacin and mortality among patients with cancer in the NHANES retrospective cohort
Abstract Background The vitamin niacin is used as a lipid-regulating supplement, but it is unknown whether niacin has a positive influence on cancer prognosis. In this study, we examine the relationship between niacin intake and mortality among patients with cancer. Methods Our study utilized all av...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-11-01
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| Series: | BMC Cancer |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12885-022-10265-4 |
| _version_ | 1798016813617905664 |
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| author | Hongan Ying Lijie Gao Nansheng Liao Xijuan Xu Wenfeng Yu Weiwen Hong |
| author_facet | Hongan Ying Lijie Gao Nansheng Liao Xijuan Xu Wenfeng Yu Weiwen Hong |
| author_sort | Hongan Ying |
| collection | DOAJ |
| description | Abstract Background The vitamin niacin is used as a lipid-regulating supplement, but it is unknown whether niacin has a positive influence on cancer prognosis. In this study, we examine the relationship between niacin intake and mortality among patients with cancer. Methods Our study utilized all available continuous data from the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2014. Multivariable Cox regression models were applied in order to investigate dietary niacin intake’s association with mortality. We compared the survival probability between groups of low and high niacin intake by plotting Kaplan-Meier curves. An analysis of subgroups was used to investigate heterogeneity sources. Results A total of 3504 participants were included in the cohort, with 1054 deaths. One thousand eight hundred forty-seven participants (52.3%) were female, 2548 participants (73.4%) were white, and the mean age (SE) was 65.38 years (0.32). According to multivariate logistic regression analysis, niacin intake was negatively associated with mortality outcomes in patients with cancer, with P values below 0.05 in all models. In subgroup analyses based on sex, age, and BMI, the association persisted. The Kaplan-Meier curves indicate that high niacin intake groups have better survival rates than low intake groups. Niacin supplementation improved cancer mortality but not all-cause mortality. Conclusion According to our study, higher dietary niacin intake was associated with lower mortality in cancer patients. Niacin supplements improved cancer survival rates, but not all causes of mortality. |
| first_indexed | 2024-04-11T15:56:40Z |
| format | Article |
| id | doaj.art-404919f6afb243d3bcdcb99382260429 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-04-11T15:56:40Z |
| publishDate | 2022-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-404919f6afb243d3bcdcb993822604292022-12-22T04:15:08ZengBMCBMC Cancer1471-24072022-11-012211910.1186/s12885-022-10265-4Association between niacin and mortality among patients with cancer in the NHANES retrospective cohortHongan Ying0Lijie Gao1Nansheng Liao2Xijuan Xu3Wenfeng Yu4Weiwen Hong5Department of Geriatrics, Taizhou First People’s HospitalDepartment of Rehabilitation, Zhujiang Hospital of Southern Medical UniversityDepartment of General Surgery, Taizhou First People’s HospitalDepartment of Anus & Intestine Surgery, Taizhou First People’s HospitalDepartment of Anus & Intestine Surgery, Taizhou First People’s HospitalDepartment of Anus & Intestine Surgery, Taizhou First People’s HospitalAbstract Background The vitamin niacin is used as a lipid-regulating supplement, but it is unknown whether niacin has a positive influence on cancer prognosis. In this study, we examine the relationship between niacin intake and mortality among patients with cancer. Methods Our study utilized all available continuous data from the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2014. Multivariable Cox regression models were applied in order to investigate dietary niacin intake’s association with mortality. We compared the survival probability between groups of low and high niacin intake by plotting Kaplan-Meier curves. An analysis of subgroups was used to investigate heterogeneity sources. Results A total of 3504 participants were included in the cohort, with 1054 deaths. One thousand eight hundred forty-seven participants (52.3%) were female, 2548 participants (73.4%) were white, and the mean age (SE) was 65.38 years (0.32). According to multivariate logistic regression analysis, niacin intake was negatively associated with mortality outcomes in patients with cancer, with P values below 0.05 in all models. In subgroup analyses based on sex, age, and BMI, the association persisted. The Kaplan-Meier curves indicate that high niacin intake groups have better survival rates than low intake groups. Niacin supplementation improved cancer mortality but not all-cause mortality. Conclusion According to our study, higher dietary niacin intake was associated with lower mortality in cancer patients. Niacin supplements improved cancer survival rates, but not all causes of mortality.https://doi.org/10.1186/s12885-022-10265-4NiacinMortalityCancerRetrospective cohort |
| spellingShingle | Hongan Ying Lijie Gao Nansheng Liao Xijuan Xu Wenfeng Yu Weiwen Hong Association between niacin and mortality among patients with cancer in the NHANES retrospective cohort BMC Cancer Niacin Mortality Cancer Retrospective cohort |
| title | Association between niacin and mortality among patients with cancer in the NHANES retrospective cohort |
| title_full | Association between niacin and mortality among patients with cancer in the NHANES retrospective cohort |
| title_fullStr | Association between niacin and mortality among patients with cancer in the NHANES retrospective cohort |
| title_full_unstemmed | Association between niacin and mortality among patients with cancer in the NHANES retrospective cohort |
| title_short | Association between niacin and mortality among patients with cancer in the NHANES retrospective cohort |
| title_sort | association between niacin and mortality among patients with cancer in the nhanes retrospective cohort |
| topic | Niacin Mortality Cancer Retrospective cohort |
| url | https://doi.org/10.1186/s12885-022-10265-4 |
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