Exploring the promising potential of induced pluripotent stem cells in cancer research and therapy
Abstract The advent of iPSCs has brought about a significant transformation in stem cell research, opening up promising avenues for advancing cancer treatment. The formation of cancer is a multifaceted process influenced by genetic, epigenetic, and environmental factors. iPSCs offer a distinctive pl...
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-11-01
|
| Series: | Molecular Cancer |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12943-023-01873-0 |
| _version_ | 1797415825953521664 |
|---|---|
| author | Matin Chehelgerdi Fereshteh Behdarvand Dehkordi Mohammad Chehelgerdi Hamidreza Kabiri Hosein Salehian-Dehkordi Mohammad Abdolvand Sharareh Salmanizadeh Mohsen Rashidi Anoosha Niazmand Saba Ahmadi Sara Feizbakhshan Saber Kabiri Nasimeh Vatandoost Tayebeh Ranjbarnejad |
| author_facet | Matin Chehelgerdi Fereshteh Behdarvand Dehkordi Mohammad Chehelgerdi Hamidreza Kabiri Hosein Salehian-Dehkordi Mohammad Abdolvand Sharareh Salmanizadeh Mohsen Rashidi Anoosha Niazmand Saba Ahmadi Sara Feizbakhshan Saber Kabiri Nasimeh Vatandoost Tayebeh Ranjbarnejad |
| author_sort | Matin Chehelgerdi |
| collection | DOAJ |
| description | Abstract The advent of iPSCs has brought about a significant transformation in stem cell research, opening up promising avenues for advancing cancer treatment. The formation of cancer is a multifaceted process influenced by genetic, epigenetic, and environmental factors. iPSCs offer a distinctive platform for investigating the origin of cancer, paving the way for novel approaches to cancer treatment, drug testing, and tailored medical interventions. This review article will provide an overview of the science behind iPSCs, the current limitations and challenges in iPSC-based cancer therapy, the ethical and social implications, and the comparative analysis with other stem cell types for cancer treatment. The article will also discuss the applications of iPSCs in tumorigenesis, the future of iPSCs in tumorigenesis research, and highlight successful case studies utilizing iPSCs in tumorigenesis research. The conclusion will summarize the advancements made in iPSC-based tumorigenesis research and the importance of continued investment in iPSC research to unlock the full potential of these cells. |
| first_indexed | 2024-03-09T05:55:10Z |
| format | Article |
| id | doaj.art-404a3a42ecac476f8ca2203a51f2f778 |
| institution | Directory Open Access Journal |
| issn | 1476-4598 |
| language | English |
| last_indexed | 2024-03-09T05:55:10Z |
| publishDate | 2023-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Cancer |
| spelling | doaj.art-404a3a42ecac476f8ca2203a51f2f7782023-12-03T12:14:25ZengBMCMolecular Cancer1476-45982023-11-01221111110.1186/s12943-023-01873-0Exploring the promising potential of induced pluripotent stem cells in cancer research and therapyMatin Chehelgerdi0Fereshteh Behdarvand Dehkordi1Mohammad Chehelgerdi2Hamidreza Kabiri3Hosein Salehian-Dehkordi4Mohammad Abdolvand5Sharareh Salmanizadeh6Mohsen Rashidi7Anoosha Niazmand8Saba Ahmadi9Sara Feizbakhshan10Saber Kabiri11Nasimeh Vatandoost12Tayebeh Ranjbarnejad13Novin Genome (NG) Lab, Research and Development Center for BiotechnologyNovin Genome (NG) Lab, Research and Development Center for BiotechnologyNovin Genome (NG) Lab, Research and Development Center for BiotechnologyNovin Genome (NG) Lab, Research and Development Center for BiotechnologyCollege of Animal Science and Technology, China Agricultural UniversityDepartment of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical ScienceDepartment of Cell and Molecular Biology and Microbiology, Faculty of Biological Science and Technology, University of IsfahanDepartment Pharmacology, Faculty of Medicine, Mazandaran University of Medical SciencesDepartment of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical ScienceDepartment of Molecular and Medical Genetics, Tbilisi State Medical UniversityDepartment of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical ScienceNovin Genome (NG) Lab, Research and Development Center for BiotechnologyPediatric Inherited Diseases Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical SciencesDepartment of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical ScienceAbstract The advent of iPSCs has brought about a significant transformation in stem cell research, opening up promising avenues for advancing cancer treatment. The formation of cancer is a multifaceted process influenced by genetic, epigenetic, and environmental factors. iPSCs offer a distinctive platform for investigating the origin of cancer, paving the way for novel approaches to cancer treatment, drug testing, and tailored medical interventions. This review article will provide an overview of the science behind iPSCs, the current limitations and challenges in iPSC-based cancer therapy, the ethical and social implications, and the comparative analysis with other stem cell types for cancer treatment. The article will also discuss the applications of iPSCs in tumorigenesis, the future of iPSCs in tumorigenesis research, and highlight successful case studies utilizing iPSCs in tumorigenesis research. The conclusion will summarize the advancements made in iPSC-based tumorigenesis research and the importance of continued investment in iPSC research to unlock the full potential of these cells.https://doi.org/10.1186/s12943-023-01873-0Induced pluripotent stem cellsTumorigenesisTherapyRegenerative medicinePersonalized medicineImmunotherapies |
| spellingShingle | Matin Chehelgerdi Fereshteh Behdarvand Dehkordi Mohammad Chehelgerdi Hamidreza Kabiri Hosein Salehian-Dehkordi Mohammad Abdolvand Sharareh Salmanizadeh Mohsen Rashidi Anoosha Niazmand Saba Ahmadi Sara Feizbakhshan Saber Kabiri Nasimeh Vatandoost Tayebeh Ranjbarnejad Exploring the promising potential of induced pluripotent stem cells in cancer research and therapy Molecular Cancer Induced pluripotent stem cells Tumorigenesis Therapy Regenerative medicine Personalized medicine Immunotherapies |
| title | Exploring the promising potential of induced pluripotent stem cells in cancer research and therapy |
| title_full | Exploring the promising potential of induced pluripotent stem cells in cancer research and therapy |
| title_fullStr | Exploring the promising potential of induced pluripotent stem cells in cancer research and therapy |
| title_full_unstemmed | Exploring the promising potential of induced pluripotent stem cells in cancer research and therapy |
| title_short | Exploring the promising potential of induced pluripotent stem cells in cancer research and therapy |
| title_sort | exploring the promising potential of induced pluripotent stem cells in cancer research and therapy |
| topic | Induced pluripotent stem cells Tumorigenesis Therapy Regenerative medicine Personalized medicine Immunotherapies |
| url | https://doi.org/10.1186/s12943-023-01873-0 |
| work_keys_str_mv | AT matinchehelgerdi exploringthepromisingpotentialofinducedpluripotentstemcellsincancerresearchandtherapy AT fereshtehbehdarvanddehkordi exploringthepromisingpotentialofinducedpluripotentstemcellsincancerresearchandtherapy AT mohammadchehelgerdi exploringthepromisingpotentialofinducedpluripotentstemcellsincancerresearchandtherapy AT hamidrezakabiri exploringthepromisingpotentialofinducedpluripotentstemcellsincancerresearchandtherapy AT hoseinsalehiandehkordi exploringthepromisingpotentialofinducedpluripotentstemcellsincancerresearchandtherapy AT mohammadabdolvand exploringthepromisingpotentialofinducedpluripotentstemcellsincancerresearchandtherapy AT shararehsalmanizadeh exploringthepromisingpotentialofinducedpluripotentstemcellsincancerresearchandtherapy AT mohsenrashidi exploringthepromisingpotentialofinducedpluripotentstemcellsincancerresearchandtherapy AT anooshaniazmand exploringthepromisingpotentialofinducedpluripotentstemcellsincancerresearchandtherapy AT sabaahmadi exploringthepromisingpotentialofinducedpluripotentstemcellsincancerresearchandtherapy AT sarafeizbakhshan exploringthepromisingpotentialofinducedpluripotentstemcellsincancerresearchandtherapy AT saberkabiri exploringthepromisingpotentialofinducedpluripotentstemcellsincancerresearchandtherapy AT nasimehvatandoost exploringthepromisingpotentialofinducedpluripotentstemcellsincancerresearchandtherapy AT tayebehranjbarnejad exploringthepromisingpotentialofinducedpluripotentstemcellsincancerresearchandtherapy |