Etiology of severe community - acquired pneumonia in adults: results of the first Russian multicenter study
Aim: to study the etiology of severe community - acquired pneumonia (SCAP) in adults in Russian Federation. SCAP is distinguished by high mortality and socio - economic burden. Both etiology and antimicrobial resistance are essential for appropriate antibiotic choice. Materials and methods. A prospe...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | Russian |
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"Consilium Medicum" Publishing house
2020-01-01
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| Series: | Терапевтический архив |
| Subjects: | |
| Online Access: | https://ter-arkhiv.ru/0040-3660/article/viewFile/33736/pdf |
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| author | I A Zakharenkov S A Rachina N N Dekhnich R S Kozlov A I Sinopalnikov N V Ivanchik S B Yatsyshina M A Elkina M V Archipenko S A Gordeeva M S Lebedeva U S Portnyagina |
| author_facet | I A Zakharenkov S A Rachina N N Dekhnich R S Kozlov A I Sinopalnikov N V Ivanchik S B Yatsyshina M A Elkina M V Archipenko S A Gordeeva M S Lebedeva U S Portnyagina |
| author_sort | I A Zakharenkov |
| collection | DOAJ |
| description | Aim: to study the etiology of severe community - acquired pneumonia (SCAP) in adults in Russian Federation. SCAP is distinguished by high mortality and socio - economic burden. Both etiology and antimicrobial resistance are essential for appropriate antibiotic choice. Materials and methods. A prospective cohort study recruited adults with confirmed diagnosis of SCAP admitted to multi - word hospitals of six Russian cities in 2014-2018. Etiology was confirmed by routine culture of blood, respiratory (sputum, endotracheal aspirate or bronchoalveolar lavage) and when appropriate, autopsy samples, urinary antigen tests (L. pneumophila serogroup 1, S. pneumoniae); real - time PCR for identification of “atypical” bacterial pathogens (M. pneumoniae, C. pneumoniae, L. pneumophila) and respiratory viruses (influenza viruses A and B, parainfluenza, human metapneumovirus, etc.) was applied. Results. Altogether 109 patients (60.6% male; mean age 50.8±18.0 years old) with SCAP were enrolled. Etiological agent was identified in 65.1% of patients, S. pneumoniae, rhinovirus, S. aureus and K. pneumoniae were the most commonly isolated pathogens (found in 43.7, 15.5, 14.1 and 11.3% of patients with positive results of microbiological investigations, respectively). Bacteriemia was seen in 14.6% of patients and most commonly associated with S. pneumoniae. Co - infection with 2 or more causative agents was revealed in 36.6% of cases. Combination of bacterial pathogens (mainly S. pneumoniae with S. aureus or/and Enterobacterales) prevailed - 57.7% of cases; associations of bacteria and viruses were identified in 38.5% of patients, different viruses - in one case. Conclusion. S. pneumoniae was the most common pathogen in adults with SCAP. A high rate of respiratory viruses (mainly rhinovirus and influenza viruses) identification both as mixt infection with bacteria and mono - infection should be taken into account. |
| first_indexed | 2024-12-14T21:18:06Z |
| format | Article |
| id | doaj.art-404b0ab847404775a69d7f95d95b42ce |
| institution | Directory Open Access Journal |
| issn | 0040-3660 2309-5342 |
| language | Russian |
| last_indexed | 2024-12-14T21:18:06Z |
| publishDate | 2020-01-01 |
| publisher | "Consilium Medicum" Publishing house |
| record_format | Article |
| series | Терапевтический архив |
| spelling | doaj.art-404b0ab847404775a69d7f95d95b42ce2022-12-21T22:47:01Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422020-01-01921364210.26442/00403660.2020.01.00049130464Etiology of severe community - acquired pneumonia in adults: results of the first Russian multicenter studyI A Zakharenkov0S A Rachina1N N Dekhnich2R S Kozlov3A I Sinopalnikov4N V Ivanchik5S B Yatsyshina6M A Elkina7M V Archipenko8S A Gordeeva9M S Lebedeva10U S Portnyagina11Bryansk city hospital №1; The Interregional Association for Clinical Microbiology and Antimicrobial ChemotherapyRUDN UniversitySmolensk State Medical UniversityThe Interregional Association for Clinical Microbiology and Antimicrobial Chemotherapy; Smolensk State Medical UniversityRussian Medical Academy of Postgraduate EducationSmolensk State Medical UniversityCentral Research Institute of EpidemiologyCentral Research Institute of EpidemiologyRegional Clinical Hospital №1P.A. Bayandin Murmansk State Regional Clinical HospitalState Budgetary Healthcare Institution «Saint-Petersburg clinical scientific and practical center for specialised types of medical care (oncological)»M.K. Ammosov Federal North-Eastern UniversityAim: to study the etiology of severe community - acquired pneumonia (SCAP) in adults in Russian Federation. SCAP is distinguished by high mortality and socio - economic burden. Both etiology and antimicrobial resistance are essential for appropriate antibiotic choice. Materials and methods. A prospective cohort study recruited adults with confirmed diagnosis of SCAP admitted to multi - word hospitals of six Russian cities in 2014-2018. Etiology was confirmed by routine culture of blood, respiratory (sputum, endotracheal aspirate or bronchoalveolar lavage) and when appropriate, autopsy samples, urinary antigen tests (L. pneumophila serogroup 1, S. pneumoniae); real - time PCR for identification of “atypical” bacterial pathogens (M. pneumoniae, C. pneumoniae, L. pneumophila) and respiratory viruses (influenza viruses A and B, parainfluenza, human metapneumovirus, etc.) was applied. Results. Altogether 109 patients (60.6% male; mean age 50.8±18.0 years old) with SCAP were enrolled. Etiological agent was identified in 65.1% of patients, S. pneumoniae, rhinovirus, S. aureus and K. pneumoniae were the most commonly isolated pathogens (found in 43.7, 15.5, 14.1 and 11.3% of patients with positive results of microbiological investigations, respectively). Bacteriemia was seen in 14.6% of patients and most commonly associated with S. pneumoniae. Co - infection with 2 or more causative agents was revealed in 36.6% of cases. Combination of bacterial pathogens (mainly S. pneumoniae with S. aureus or/and Enterobacterales) prevailed - 57.7% of cases; associations of bacteria and viruses were identified in 38.5% of patients, different viruses - in one case. Conclusion. S. pneumoniae was the most common pathogen in adults with SCAP. A high rate of respiratory viruses (mainly rhinovirus and influenza viruses) identification both as mixt infection with bacteria and mono - infection should be taken into account.https://ter-arkhiv.ru/0040-3660/article/viewFile/33736/pdfsevere community acquired pneumoniaetiologymicrobiological diagnostics |
| spellingShingle | I A Zakharenkov S A Rachina N N Dekhnich R S Kozlov A I Sinopalnikov N V Ivanchik S B Yatsyshina M A Elkina M V Archipenko S A Gordeeva M S Lebedeva U S Portnyagina Etiology of severe community - acquired pneumonia in adults: results of the first Russian multicenter study Терапевтический архив severe community acquired pneumonia etiology microbiological diagnostics |
| title | Etiology of severe community - acquired pneumonia in adults: results of the first Russian multicenter study |
| title_full | Etiology of severe community - acquired pneumonia in adults: results of the first Russian multicenter study |
| title_fullStr | Etiology of severe community - acquired pneumonia in adults: results of the first Russian multicenter study |
| title_full_unstemmed | Etiology of severe community - acquired pneumonia in adults: results of the first Russian multicenter study |
| title_short | Etiology of severe community - acquired pneumonia in adults: results of the first Russian multicenter study |
| title_sort | etiology of severe community acquired pneumonia in adults results of the first russian multicenter study |
| topic | severe community acquired pneumonia etiology microbiological diagnostics |
| url | https://ter-arkhiv.ru/0040-3660/article/viewFile/33736/pdf |
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