Hotspots of Somatic Genetic Variation in Pituitary Neuroendocrine Tumors

Hotspots of Somatic Genetic Variation in Pituitary Neuroendocrine Tumors

The most common genetic drivers of pituitary neuroendocrine tumors (PitNETs) lie within mutational hotspots, which are genomic regions where variants tend to cluster. Some of these hotspot defects are unique to PitNETs, while others are associated with additional neoplasms. Hotspot variants in <i...

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Bibliographic Details
Main Authors: Mariana Torres-Morán, Alexa L. Franco-Álvarez, Rosa G. Rebollar-Vega, Laura C. Hernández-Ramírez
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Cancers
Subjects:
genetic driver
mutational hotspot
pituitary neuroendocrine tumor
somatic variant
druggable target
Online Access:https://www.mdpi.com/2072-6694/15/23/5685

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