Transient Receptor Potential Ankyrin-1 (TRPA1) Block Protects against Loss of White Matter Function during Ischaemia in the Mouse Optic Nerve

Transient Receptor Potential Ankyrin-1 (TRPA1) Block Protects against Loss of White Matter Function during Ischaemia in the Mouse Optic Nerve

Oligodendrocytes produce myelin, which provides insulation to axons and speeds up neuronal transmission. In ischaemic conditions, myelin is damaged, resulting in mental and physical disabilities. Recent evidence suggests that oligodendrocyte damage during ischaemia can be mediated by Transient Recep...

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Bibliographic Details
Main Authors: Wendy Lajoso, Grace Flower, Vincenzo Giacco, Anjuli Kaul, Circe La Mache, Andra Brăban, Angela Roxas, Nicola B. Hamilton
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Pharmaceuticals
Subjects:
transient receptor potential ankyrin-1 (TRPA1)
oxygen and glucose deprivation
ischaemia
oligodendrocytes
optic nerve
myelin
Online Access:https://www.mdpi.com/1424-8247/14/9/909

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