P2X7 receptor contributes to long-term neuroinflammation and cognitive impairment in sepsis-surviving mice

P2X7 receptor contributes to long-term neuroinflammation and cognitive impairment in sepsis-surviving mice

Introduction: Sepsis is defined as a multifactorial debilitating condition with high risks of death. The intense inflammatory response causes deleterious effects on the brain, a condition called sepsis-associated encephalopathy. Neuroinflammation or pathogen recognition are able to stress cells, res...

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Main Authors: Vinícius Santos Alves, Joyce Pereira da Silva, Fabiana Cristina Rodrigues, Suzana Maria Bernardino Araújo, André Luiz Gouvêa, Raíssa Leite-Aguiar, Stephanie Alexia Cristina Silva Santos, Milla Souza Pessoa da Silva, Fernanda Silva Ferreira, Eduardo Peil Marques, Beatriz Amanda Barbosa Rangel dos Passos, Tatiana Maron-Gutierrez, Eleonora Kurtenbach, Robson da Costa, Cláudia Pinto Figueiredo, Angela T. S. Wyse, Robson Coutinho-Silva, Luiz Eduardo Baggio Savio
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Pharmacology
Subjects:
sepsis-associated encephalopathy
P2X7 receptor
cognitive impairment
neuroinflammation
Brilliant Blue G
acetylcholinesterase
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1179723/full

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