Three-Step Synthesis of the Antiepileptic Drug Candidate Pynegabine

Three-Step Synthesis of the Antiepileptic Drug Candidate Pynegabine

Pynegabine, an antiepileptic drug candidate in phase I clinical trials, is a structural analog of the marketed drug retigabine with improved chemical stability, strong efficacy, and a better safety margin. The reported shortest synthetic route for pynegabine contains six steps and involves the manip...

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Bibliographic Details
Main Authors: Yi-Jing Sun, Ya-Ling Gong, Shi-Chao Lu, Shi-Peng Zhang, Shu Xu
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Molecules
Subjects:
antiepileptic drug
pynegabine
Buchwald–Hartwig cross coupling
Online Access:https://www.mdpi.com/1420-3049/28/13/4888

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