EPHA2 mediates PDGFA activity and functions together with PDGFRA as prognostic marker and therapeutic target in glioblastoma

EPHA2 mediates PDGFA activity and functions together with PDGFRA as prognostic marker and therapeutic target in glioblastoma

Abstract Platelet-derived growth subunit A (PDGFA) plays critical roles in development of glioblastoma (GBM) with substantial evidence from TCGA database analyses and in vivo mouse models. So far, only platelet-derived growth receptor α (PDGFRA) has been identified as receptor for PDGFA. However, PD...

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Main Authors: Qu-Jing Gai, Zhen Fu, Jiang He, Min Mao, Xiao-Xue Yao, Yan Qin, Xi Lan, Lin Zhang, Jing-Ya Miao, Yan-Xia Wang, Jiang Zhu, Fei-Cheng Yang, Hui-Min Lu, Ze-Xuan Yan, Fang-Lin Chen, Yu Shi, Yi-Fang Ping, You-Hong Cui, Xia Zhang, Xindong Liu, Xiao-Hong Yao, Sheng-Qing Lv, Xiu-Wu Bian, Yan Wang
Format: Article
Language:English
Published: Nature Publishing Group 2022-02-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-021-00855-2

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