Cardiovascular extracellular microRNAs: emerging diagnostic markers and mechanisms of cell-to-cell RNA communication
Cardiovascular diseases are a leading cause of morbidity and mortality in Western societies. It is now well established that microRNAs (miRNAs) are determinant regulators in various medical conditions including cardiovascular diseases. The recent discovery that miRNAs, while associated with differen...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-11-01
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| Series: | Frontiers in Genetics |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fgene.2013.00214/full |
| _version_ | 1818966899252264960 |
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| author | Virginie Kinet Julie Halkein Ellen Dirkx Leon J. De Windt |
| author_facet | Virginie Kinet Julie Halkein Ellen Dirkx Leon J. De Windt |
| author_sort | Virginie Kinet |
| collection | DOAJ |
| description | Cardiovascular diseases are a leading cause of morbidity and mortality in Western societies. It is now well established that microRNAs (miRNAs) are determinant regulators in various medical conditions including cardiovascular diseases. The recent discovery that miRNAs, while associated with different carriers, can be exported out of the cell, has triggered a renewed interest to analyze the potential to use extracellular miRNAs as tools for diagnostic and therapeutic studies. Circulating miRNAs in biological fluids present a technological advantage compared to current diagnostic tools by virtue of their remarkable stability and relative ease of detection rendering them ideal tools for non-invasive and rapid diagnosis. Extracellular miRNAs also represent a novel form of inter-cellular communication by transferring genetic information from a donor cell to a recipient cell. This review briefly summarizes recent insights in the origin, function and diagnostic potential of extracellular miRNAs by focusing on a select number of cardiovascular diseases. |
| first_indexed | 2024-12-20T13:40:14Z |
| format | Article |
| id | doaj.art-4052e5303a3b407f9bbb2f80d09e9a71 |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-12-20T13:40:14Z |
| publishDate | 2013-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-4052e5303a3b407f9bbb2f80d09e9a712022-12-21T19:38:49ZengFrontiers Media S.A.Frontiers in Genetics1664-80212013-11-01410.3389/fgene.2013.0021453550Cardiovascular extracellular microRNAs: emerging diagnostic markers and mechanisms of cell-to-cell RNA communicationVirginie KinetJulie HalkeinEllen DirkxLeon J. De WindtCardiovascular diseases are a leading cause of morbidity and mortality in Western societies. It is now well established that microRNAs (miRNAs) are determinant regulators in various medical conditions including cardiovascular diseases. The recent discovery that miRNAs, while associated with different carriers, can be exported out of the cell, has triggered a renewed interest to analyze the potential to use extracellular miRNAs as tools for diagnostic and therapeutic studies. Circulating miRNAs in biological fluids present a technological advantage compared to current diagnostic tools by virtue of their remarkable stability and relative ease of detection rendering them ideal tools for non-invasive and rapid diagnosis. Extracellular miRNAs also represent a novel form of inter-cellular communication by transferring genetic information from a donor cell to a recipient cell. This review briefly summarizes recent insights in the origin, function and diagnostic potential of extracellular miRNAs by focusing on a select number of cardiovascular diseases.https://www.frontiersin.org/article/10.3389/fgene.2013.00214/fullextracellular microRNAinter-cellular communicationsbiomarkerscardiovascular diseases |
| spellingShingle | Virginie Kinet Julie Halkein Ellen Dirkx Leon J. De Windt Cardiovascular extracellular microRNAs: emerging diagnostic markers and mechanisms of cell-to-cell RNA communication Frontiers in Genetics extracellular microRNA inter-cellular communications biomarkers cardiovascular diseases |
| title | Cardiovascular extracellular microRNAs: emerging diagnostic markers and mechanisms of cell-to-cell RNA communication |
| title_full | Cardiovascular extracellular microRNAs: emerging diagnostic markers and mechanisms of cell-to-cell RNA communication |
| title_fullStr | Cardiovascular extracellular microRNAs: emerging diagnostic markers and mechanisms of cell-to-cell RNA communication |
| title_full_unstemmed | Cardiovascular extracellular microRNAs: emerging diagnostic markers and mechanisms of cell-to-cell RNA communication |
| title_short | Cardiovascular extracellular microRNAs: emerging diagnostic markers and mechanisms of cell-to-cell RNA communication |
| title_sort | cardiovascular extracellular micrornas emerging diagnostic markers and mechanisms of cell to cell rna communication |
| topic | extracellular microRNA inter-cellular communications biomarkers cardiovascular diseases |
| url | https://www.frontiersin.org/article/10.3389/fgene.2013.00214/full |
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