Kynurenic Acid Levels are Increased in the CSF of Alzheimer’s Disease Patients

Kynurenic Acid Levels are Increased in the CSF of Alzheimer’s Disease Patients

Kynurenic acid (KYNA) is a product of the tryptophan (TRP) metabolism via the kynurenine pathway (KP). This pathway is activated in neurodegenerative disorders, such as Alzheimer´s disease (AD). KYNA is primarily produced by astrocytes and is considered neuroprotective. Thus, altered KYNA levels may...

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Bibliographic Details
Main Authors: Marta González-Sánchez, Javier Jiménez, Arantzazu Narváez, Desiree Antequera, Sara Llamas-Velasco, Alejandro Herrero-San Martín, Jose Antonio Molina Arjona, Adolfo López de Munain, Alberto Lleó Bisa, M.-Pilar Marco, Montserrat Rodríguez-Núñez, David Andrés Pérez-Martínez, Alberto Villarejo-Galende, Fernando Bartolome, Elena Domínguez, Eva Carro
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Biomolecules
Subjects:
Alzheimer´s disease
kynurenine pathway
cerebrospinal fluid
biomarkers
amyloid-β
tau protein
Online Access:https://www.mdpi.com/2218-273X/10/4/571

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