Enhanced IFNα Signaling Promotes Ligand-Independent Activation of ERα to Promote Aromatase Inhibitor Resistance in Breast Cancer

Enhanced IFNα Signaling Promotes Ligand-Independent Activation of ERα to Promote Aromatase Inhibitor Resistance in Breast Cancer

Aromatase inhibitors (AIs) reduce estrogen levels up to 98% as the standard practice to treat postmenopausal women with estrogen receptor-positive (ER+) breast cancer. However, approximately 30% of ER+ breast cancers develop resistance to treatment. Enhanced interferon-alpha (IFNα) signaling is upre...

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Bibliographic Details
Main Authors: Taylor E. Escher, Prasad Dandawate, Afreen Sayed, Christy R. Hagan, Shrikant Anant, Joan Lewis-Wambi
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Cancers
Subjects:
breast cancer
aromatase inhibitor
estrogen deprivation
AI resistance
estrogen receptor
interferon alpha
Online Access:https://www.mdpi.com/2072-6694/13/20/5130

Internet

https://www.mdpi.com/2072-6694/13/20/5130

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