Improving CAR T-Cell Persistence

Improving CAR T-Cell Persistence

Over the last decade remarkable progress has been made in enhancing the efficacy of CAR T therapies. However, the clinical benefits are still limited, especially in solid tumors. Even in hematological settings, patients that respond to CAR T therapies remain at risk of relapsing due to several facto...

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Bibliographic Details
Main Authors: Violena Pietrobon, Lauren Anne Todd, Anghsumala Goswami, Ofir Stefanson, Zhifen Yang, Francesco Marincola
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:International Journal of Molecular Sciences
Subjects:
persistence
exhaustion
CAR
lymphodepletion
culturing conditions
stemness
Online Access:https://www.mdpi.com/1422-0067/22/19/10828

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