Simultaneous Upregulation of Elastolytic and Elastogenic Factors Are Necessary for Regulated Collateral Diameter Expansion

Simultaneous Upregulation of Elastolytic and Elastogenic Factors Are Necessary for Regulated Collateral Diameter Expansion

Background: During arteriogenesis, outward remodeling of the arterial wall expands luminal diameter to produce increased conductance in developing collaterals. We have previously shown that diameter expansion without loss of internal elastic lamina (IEL) integrity requires both degradation of elasti...

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Bibliographic Details
Main Authors: Elizabeth Andraska, Nolan Skirtich, Dylan McCreary, Rohan Kulkarni, Edith Tzeng, Ryan McEnaney
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
arteriogenesis
elastic fiber
extracellular matrix
remodeling
collateral
arterial occlusive disease
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2021.762094/full

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