Detection of SARS Coronavirus in Patients with Suspected SARS
Cases of severe acute respiratory syndrome (SARS) were investigated for SARS coronavirus (SARS-CoV) through RNA tests, serologic response, and viral culture. Of 537 specimens from patients in whom SARS was clinically diagnosed, 332 (60%) had SARS-CoV RNA in one or more clinical specimens, compared w...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2004-02-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/10/2/03-0610_article |
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| author | Kwok H. Chan Leo L.L.M. Poon V.C.C. Cheng Yi Guan I.F.N. Hung Joseph S.M. Peiris Loretta Y.C. Yam Wing H. Seto Kwok Y. Yuen Joseph S. Malik Peiris |
| author_facet | Kwok H. Chan Leo L.L.M. Poon V.C.C. Cheng Yi Guan I.F.N. Hung Joseph S.M. Peiris Loretta Y.C. Yam Wing H. Seto Kwok Y. Yuen Joseph S. Malik Peiris |
| author_sort | Kwok H. Chan |
| collection | DOAJ |
| description | Cases of severe acute respiratory syndrome (SARS) were investigated for SARS coronavirus (SARS-CoV) through RNA tests, serologic response, and viral culture. Of 537 specimens from patients in whom SARS was clinically diagnosed, 332 (60%) had SARS-CoV RNA in one or more clinical specimens, compared with 1 (0.3%) of 332 samples from controls. Of 417 patients with clinical SARS from whom paired serum samples were available, 92% had an antibody response. Rates of viral RNA positivity increased progressively and peaked at day 11 after onset of illness. Although viral RNA remained detectable in respiratory secretions and stool and urine specimens for >30 days in some patients, virus could not be cultured after week 3 of illness. Nasopharyngeal aspirates, throat swabs, or sputum samples were the most useful clinical specimens in the first 5 days of illness, but later in the illness viral RNA could be detected more readily in stool specimens. |
| first_indexed | 2024-12-11T18:17:57Z |
| format | Article |
| id | doaj.art-4055efb2b24a4cd89d2442b9d820860b |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-11T18:17:57Z |
| publishDate | 2004-02-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-4055efb2b24a4cd89d2442b9d820860b2022-12-22T00:55:21ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592004-02-0110229429910.3201/eid1002.030610Detection of SARS Coronavirus in Patients with Suspected SARSKwok H. ChanLeo L.L.M. PoonV.C.C. ChengYi GuanI.F.N. HungJoseph S.M. PeirisLoretta Y.C. YamWing H. SetoKwok Y. YuenJoseph S. Malik PeirisCases of severe acute respiratory syndrome (SARS) were investigated for SARS coronavirus (SARS-CoV) through RNA tests, serologic response, and viral culture. Of 537 specimens from patients in whom SARS was clinically diagnosed, 332 (60%) had SARS-CoV RNA in one or more clinical specimens, compared with 1 (0.3%) of 332 samples from controls. Of 417 patients with clinical SARS from whom paired serum samples were available, 92% had an antibody response. Rates of viral RNA positivity increased progressively and peaked at day 11 after onset of illness. Although viral RNA remained detectable in respiratory secretions and stool and urine specimens for >30 days in some patients, virus could not be cultured after week 3 of illness. Nasopharyngeal aspirates, throat swabs, or sputum samples were the most useful clinical specimens in the first 5 days of illness, but later in the illness viral RNA could be detected more readily in stool specimens.https://wwwnc.cdc.gov/eid/article/10/2/03-0610_articleSARSsevere acute respiratory syndromeSARS coronavirusvirusepidemiologytransmission |
| spellingShingle | Kwok H. Chan Leo L.L.M. Poon V.C.C. Cheng Yi Guan I.F.N. Hung Joseph S.M. Peiris Loretta Y.C. Yam Wing H. Seto Kwok Y. Yuen Joseph S. Malik Peiris Detection of SARS Coronavirus in Patients with Suspected SARS Emerging Infectious Diseases SARS severe acute respiratory syndrome SARS coronavirus virus epidemiology transmission |
| title | Detection of SARS Coronavirus in Patients with Suspected SARS |
| title_full | Detection of SARS Coronavirus in Patients with Suspected SARS |
| title_fullStr | Detection of SARS Coronavirus in Patients with Suspected SARS |
| title_full_unstemmed | Detection of SARS Coronavirus in Patients with Suspected SARS |
| title_short | Detection of SARS Coronavirus in Patients with Suspected SARS |
| title_sort | detection of sars coronavirus in patients with suspected sars |
| topic | SARS severe acute respiratory syndrome SARS coronavirus virus epidemiology transmission |
| url | https://wwwnc.cdc.gov/eid/article/10/2/03-0610_article |
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