Metformin Ameliorates Inflammation and Airway Remodeling of Experimental Allergic Asthma in Mice by Restoring AMPKα Activity

Metformin Ameliorates Inflammation and Airway Remodeling of Experimental Allergic Asthma in Mice by Restoring AMPKα Activity

Metformin has been involved in modulating inflammatory state and inhibiting cell proliferation and angiogenesis. This study aimed to determine whether metformin alleviates airway inflammation and remodeling of experimental allergic asthma and elucidate the underlying mechanism. We sensitized and cha...

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Bibliographic Details
Main Authors: Wenxian Ma, Qiaoyan Jin, Haiqin Guo, Xinpeng Han, Lingbin Xu, Shemin Lu, Changgui Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Pharmacology
Subjects:
asthma
airway inflammation
airway remodeling
metformin
AMPK
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.780148/full

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