Two New Isoprenoid Flavonoids from <i>Sophora flavescens</i> with Antioxidant and Cytotoxic Activities
<i>Sophora flavescens</i> is a regularly used traditional Chinese medicine. In an attempt to discover adequate active agents, the isoprenoid flavonoids from <i>S. flavescens</i> were further investigated. In this work, two new compounds (<b>1</b>–<b>2</b&...
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MDPI AG
2021-11-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/23/7228 |
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| author | Jingjing Li Yan Lin Lei He Rongxiu Ou Tao Chen Xu Zhang Qirui Li Zhu Zeng Qingde Long |
| author_facet | Jingjing Li Yan Lin Lei He Rongxiu Ou Tao Chen Xu Zhang Qirui Li Zhu Zeng Qingde Long |
| author_sort | Jingjing Li |
| collection | DOAJ |
| description | <i>Sophora flavescens</i> is a regularly used traditional Chinese medicine. In an attempt to discover adequate active agents, the isoprenoid flavonoids from <i>S. flavescens</i> were further investigated. In this work, two new compounds (<b>1</b>–<b>2</b>, kurarinol A-B) together with 26 known ones (<b>3</b>–<b>28</b>) were isolated and elucidated on the basis of extensive NMR, UV and MS analyses. Furthermore, the antioxidant activity of all constituents was assessed through ABTS, PTIO and DPPH methodologies and also were evaluated for cytotoxic activity by three tumor cell lines (HepG2, A549 and MCF7) and one human normal cell line (LO2 cells). As a result, a multitude of components revealed significant inhibitory activity. In particular, compound <b>1</b>–<b>2</b> (kurarinol A-B), two new flavanonols derivatives, exhibited the most potent ABTS inhibitory activity with IC<sub>50</sub> of 1.21 µg/mL and 1.81 µg/mL, respectively. Meanwhile, the new compound <b>1</b> demonstrated remarkable cytotoxicity against three cancer cells lines with IC<sub>50</sub> values ranging from 7.50–10.55 μM but showed little effect on the normal cell. The two new isoprenoid flavonoids could be promising antioxidant and anti-tumor nature agents. |
| first_indexed | 2024-03-10T04:47:11Z |
| format | Article |
| id | doaj.art-4056d7c22d53473ba6ed79df2311c3e1 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T04:47:11Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-4056d7c22d53473ba6ed79df2311c3e12023-11-23T02:49:29ZengMDPI AGMolecules1420-30492021-11-012623722810.3390/molecules26237228Two New Isoprenoid Flavonoids from <i>Sophora flavescens</i> with Antioxidant and Cytotoxic ActivitiesJingjing Li0Yan Lin1Lei He2Rongxiu Ou3Tao Chen4Xu Zhang5Qirui Li6Zhu Zeng7Qingde Long8Guizhou Provincial Key Laboratory of Pharmaceutics, Guiyang 550025, ChinaGuizhou Provincial Key Laboratory of Pharmaceutics, Guiyang 550025, ChinaGuizhou Provincial Key Laboratory of Pharmaceutics, Guiyang 550025, ChinaGuizhou Provincial Key Laboratory of Pharmaceutics, Guiyang 550025, ChinaGuizhou Provincial Key Laboratory of Pharmaceutics, Guiyang 550025, ChinaGuizhou Provincial Key Laboratory of Pharmaceutics, Guiyang 550025, ChinaGuizhou Provincial Key Laboratory of Pharmaceutics, Guiyang 550025, ChinaGuizhou Provincial Key Laboratory of Pharmaceutics, Guiyang 550025, ChinaGuizhou Provincial Key Laboratory of Pharmaceutics, Guiyang 550025, China<i>Sophora flavescens</i> is a regularly used traditional Chinese medicine. In an attempt to discover adequate active agents, the isoprenoid flavonoids from <i>S. flavescens</i> were further investigated. In this work, two new compounds (<b>1</b>–<b>2</b>, kurarinol A-B) together with 26 known ones (<b>3</b>–<b>28</b>) were isolated and elucidated on the basis of extensive NMR, UV and MS analyses. Furthermore, the antioxidant activity of all constituents was assessed through ABTS, PTIO and DPPH methodologies and also were evaluated for cytotoxic activity by three tumor cell lines (HepG2, A549 and MCF7) and one human normal cell line (LO2 cells). As a result, a multitude of components revealed significant inhibitory activity. In particular, compound <b>1</b>–<b>2</b> (kurarinol A-B), two new flavanonols derivatives, exhibited the most potent ABTS inhibitory activity with IC<sub>50</sub> of 1.21 µg/mL and 1.81 µg/mL, respectively. Meanwhile, the new compound <b>1</b> demonstrated remarkable cytotoxicity against three cancer cells lines with IC<sub>50</sub> values ranging from 7.50–10.55 μM but showed little effect on the normal cell. The two new isoprenoid flavonoids could be promising antioxidant and anti-tumor nature agents.https://www.mdpi.com/1420-3049/26/23/7228<i>Sophora flavescens</i>isoprenoid flavonoidsantioxidant activitycytotoxicity |
| spellingShingle | Jingjing Li Yan Lin Lei He Rongxiu Ou Tao Chen Xu Zhang Qirui Li Zhu Zeng Qingde Long Two New Isoprenoid Flavonoids from <i>Sophora flavescens</i> with Antioxidant and Cytotoxic Activities Molecules <i>Sophora flavescens</i> isoprenoid flavonoids antioxidant activity cytotoxicity |
| title | Two New Isoprenoid Flavonoids from <i>Sophora flavescens</i> with Antioxidant and Cytotoxic Activities |
| title_full | Two New Isoprenoid Flavonoids from <i>Sophora flavescens</i> with Antioxidant and Cytotoxic Activities |
| title_fullStr | Two New Isoprenoid Flavonoids from <i>Sophora flavescens</i> with Antioxidant and Cytotoxic Activities |
| title_full_unstemmed | Two New Isoprenoid Flavonoids from <i>Sophora flavescens</i> with Antioxidant and Cytotoxic Activities |
| title_short | Two New Isoprenoid Flavonoids from <i>Sophora flavescens</i> with Antioxidant and Cytotoxic Activities |
| title_sort | two new isoprenoid flavonoids from i sophora flavescens i with antioxidant and cytotoxic activities |
| topic | <i>Sophora flavescens</i> isoprenoid flavonoids antioxidant activity cytotoxicity |
| url | https://www.mdpi.com/1420-3049/26/23/7228 |
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