The association between soluble klotho and cardiovascular parameters in chronic kidney disease: results from the KNOW-CKD study
Abstract Background Klotho, a protein linked to aging, has emerged as a pivotal player in mineral bone metabolism and might explain the relationship between chronic kidney disease (CKD) and cardiovascular disease (CVD). The present study aimed to investigate the association between serum klotho and...
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| Format: | Article |
| Language: | English |
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BMC
2018-03-01
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| Series: | BMC Nephrology |
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| Online Access: | http://link.springer.com/article/10.1186/s12882-018-0851-3 |
| _version_ | 1818992826262749184 |
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| author | Hyo Jin Kim Eunjeong Kang Yun Kyu Oh Yeong Hoon Kim Seung Hyeok Han Tae Hyun Yoo Dong-Wan Chae Joongyub Lee Curie Ahn Kook-Hwan Oh |
| author_facet | Hyo Jin Kim Eunjeong Kang Yun Kyu Oh Yeong Hoon Kim Seung Hyeok Han Tae Hyun Yoo Dong-Wan Chae Joongyub Lee Curie Ahn Kook-Hwan Oh |
| author_sort | Hyo Jin Kim |
| collection | DOAJ |
| description | Abstract Background Klotho, a protein linked to aging, has emerged as a pivotal player in mineral bone metabolism and might explain the relationship between chronic kidney disease (CKD) and cardiovascular disease (CVD). The present study aimed to investigate the association between serum klotho and cardiac parameters from a large-scale Korean CKD cohort. Methods We analyzed 2101 participants from KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease (KNOW-CKD) cohort who had been measured for serum klotho levels. Left ventricular hypertrophy evaluated by left ventricular mass index (LVMI) and arterial stiffness measured by brachial-to-ankle pulse wave velocity (baPWV) were explored as cardiovascular parameters. Results Patients were 53.6 ± 12.2 years old and 61.1% were male. The mean estimated glomerular filtration rate (eGFR) was 53.0 ± 30.7 mL/min/1.73m2. The median serum klotho level was 536 (interquartile range [IQR]: 420–667) pg/mL. Advanced CKD stages were associated with lower serum klotho levels (P < 0.001, P for linear trend < 0.001). Ascending quartiles of klotho were significantly associated with decreased LMVI (P < 0.001, P for linear trend< 0.001). A multivariable linear regression model showed serum klotho had a significant inverse association with LVMI (β − 0.04; 95% CI [confidence interval] -0.004, − 0.00007; P = 0.041). However, there was no significant association between serum klotho and baPWV after adjustment (β 0.003; 95% CI -0.04, 0.05; P = 0.876). Trial registration This trial was registered on ClinicalTrials.gov on 28 June 2012 (NCT01630486). Conclusions Serum klotho was an independent biomarker of LVMI, but not arterial stiffness. |
| first_indexed | 2024-12-20T20:32:20Z |
| format | Article |
| id | doaj.art-40577a861175400d8505721109403ed8 |
| institution | Directory Open Access Journal |
| issn | 1471-2369 |
| language | English |
| last_indexed | 2024-12-20T20:32:20Z |
| publishDate | 2018-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Nephrology |
| spelling | doaj.art-40577a861175400d8505721109403ed82022-12-21T19:27:20ZengBMCBMC Nephrology1471-23692018-03-011911810.1186/s12882-018-0851-3The association between soluble klotho and cardiovascular parameters in chronic kidney disease: results from the KNOW-CKD studyHyo Jin Kim0Eunjeong Kang1Yun Kyu Oh2Yeong Hoon Kim3Seung Hyeok Han4Tae Hyun Yoo5Dong-Wan Chae6Joongyub Lee7Curie Ahn8Kook-Hwan Oh9Department of Internal Medicine, Dongguk University College of MedicineDepartment of Internal Medicine, Seoul National University College of MedicineDepartment of Internal Medicine, Seoul National University College of MedicineDepartment of Internal Medicine, Inje University, Busan Paik HospitalDepartment of Internal Medicine, Yonsei University College of MedicineDepartment of Internal Medicine, Yonsei University College of MedicineDepartment of Internal Medicine, Seoul National University College of MedicineMedical Research Collaborating Center, Seoul National University Hospital and Seoul, National University College of MedicineDepartment of Internal Medicine, Seoul National University College of MedicineDepartment of Internal Medicine, Seoul National University College of MedicineAbstract Background Klotho, a protein linked to aging, has emerged as a pivotal player in mineral bone metabolism and might explain the relationship between chronic kidney disease (CKD) and cardiovascular disease (CVD). The present study aimed to investigate the association between serum klotho and cardiac parameters from a large-scale Korean CKD cohort. Methods We analyzed 2101 participants from KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease (KNOW-CKD) cohort who had been measured for serum klotho levels. Left ventricular hypertrophy evaluated by left ventricular mass index (LVMI) and arterial stiffness measured by brachial-to-ankle pulse wave velocity (baPWV) were explored as cardiovascular parameters. Results Patients were 53.6 ± 12.2 years old and 61.1% were male. The mean estimated glomerular filtration rate (eGFR) was 53.0 ± 30.7 mL/min/1.73m2. The median serum klotho level was 536 (interquartile range [IQR]: 420–667) pg/mL. Advanced CKD stages were associated with lower serum klotho levels (P < 0.001, P for linear trend < 0.001). Ascending quartiles of klotho were significantly associated with decreased LMVI (P < 0.001, P for linear trend< 0.001). A multivariable linear regression model showed serum klotho had a significant inverse association with LVMI (β − 0.04; 95% CI [confidence interval] -0.004, − 0.00007; P = 0.041). However, there was no significant association between serum klotho and baPWV after adjustment (β 0.003; 95% CI -0.04, 0.05; P = 0.876). Trial registration This trial was registered on ClinicalTrials.gov on 28 June 2012 (NCT01630486). Conclusions Serum klotho was an independent biomarker of LVMI, but not arterial stiffness.http://link.springer.com/article/10.1186/s12882-018-0851-3Serum klothoSoluble klothoChronic kidney diseaseLeft ventricular mass indexLeft ventricular hypertrophyPulse wave velocity |
| spellingShingle | Hyo Jin Kim Eunjeong Kang Yun Kyu Oh Yeong Hoon Kim Seung Hyeok Han Tae Hyun Yoo Dong-Wan Chae Joongyub Lee Curie Ahn Kook-Hwan Oh The association between soluble klotho and cardiovascular parameters in chronic kidney disease: results from the KNOW-CKD study BMC Nephrology Serum klotho Soluble klotho Chronic kidney disease Left ventricular mass index Left ventricular hypertrophy Pulse wave velocity |
| title | The association between soluble klotho and cardiovascular parameters in chronic kidney disease: results from the KNOW-CKD study |
| title_full | The association between soluble klotho and cardiovascular parameters in chronic kidney disease: results from the KNOW-CKD study |
| title_fullStr | The association between soluble klotho and cardiovascular parameters in chronic kidney disease: results from the KNOW-CKD study |
| title_full_unstemmed | The association between soluble klotho and cardiovascular parameters in chronic kidney disease: results from the KNOW-CKD study |
| title_short | The association between soluble klotho and cardiovascular parameters in chronic kidney disease: results from the KNOW-CKD study |
| title_sort | association between soluble klotho and cardiovascular parameters in chronic kidney disease results from the know ckd study |
| topic | Serum klotho Soluble klotho Chronic kidney disease Left ventricular mass index Left ventricular hypertrophy Pulse wave velocity |
| url | http://link.springer.com/article/10.1186/s12882-018-0851-3 |
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