Exploring the Effects of Short-Term Daily Intake of <i>Nitraria retusa</i> Tea on Lipid Profile: A Pre-Post, Uncontrolled Pilot Study in Both Healthy and Overweight/Obese Adults
In the present study, we aimed to explore the feasibility, compliance, and potential benefits of <i>Nitraria retusa</i> extract (NRE) intervention in both healthy (BMI ≤ 24.9 Kg/m<sup>2</sup>) and overweight/obese adults (BMI > 25 Kg/m<sup>2</sup>). A total of...
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MDPI AG
2023-08-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/16/3649 |
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| author | Aicha Laouani Hana Nasrallah Awatef Sassi Farhana Ferdousi Feten Zar Kalai Yosra Hasni Khalifa Limem Hiroko Isoda Saad Saguem |
| author_facet | Aicha Laouani Hana Nasrallah Awatef Sassi Farhana Ferdousi Feten Zar Kalai Yosra Hasni Khalifa Limem Hiroko Isoda Saad Saguem |
| author_sort | Aicha Laouani |
| collection | DOAJ |
| description | In the present study, we aimed to explore the feasibility, compliance, and potential benefits of <i>Nitraria retusa</i> extract (NRE) intervention in both healthy (BMI ≤ 24.9 Kg/m<sup>2</sup>) and overweight/obese adults (BMI > 25 Kg/m<sup>2</sup>). A total of 98 participants, including 37 healthy individuals and 61 overweight/obese adults, were randomly assigned to either a low-dose (500 mg/day) or a high-dose (2000 mg/day) NRE intervention group. Plasma lipid biomarkers, liver and kidney functions, general hematology, and blood glucose levels were measured at the baseline and 10 days after intervention. While the lipid profile of the healthy participants did not show any statistically significant changes, the obese participants in the high-dose group experienced a significant decrease in triglyceride levels (within-group difference <i>p</i> value = 0.004) and an increase in HDL levels (within-group <i>p</i> value < 0.001). No significant differences were observed in other parameters, indicating that NRE at the given doses was safe. Furthermore, the study had impressive compliance and acceptability, with over 90% of participants completing the intervention and diligently following the study protocol. This pilot study represents the first investigation into the feasibility, acceptability, and potential benefits of NRE intervention on lipid profiles in human volunteers. |
| first_indexed | 2024-03-10T23:40:24Z |
| format | Article |
| id | doaj.art-40594ac2e3d240508b33f4b10c5e98ea |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T23:40:24Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-40594ac2e3d240508b33f4b10c5e98ea2023-11-19T02:31:14ZengMDPI AGNutrients2072-66432023-08-011516364910.3390/nu15163649Exploring the Effects of Short-Term Daily Intake of <i>Nitraria retusa</i> Tea on Lipid Profile: A Pre-Post, Uncontrolled Pilot Study in Both Healthy and Overweight/Obese AdultsAicha Laouani0Hana Nasrallah1Awatef Sassi2Farhana Ferdousi3Feten Zar Kalai4Yosra Hasni5Khalifa Limem6Hiroko Isoda7Saad Saguem8Laboratory of Metabolic Biophysics and Applied Pharmacology, Faculty of Medicine, University of Sousse, Sousse 4002, TunisiaLaboratory of Metabolic Biophysics and Applied Pharmacology, Faculty of Medicine, University of Sousse, Sousse 4002, TunisiaLaboratory of Metabolic Biophysics and Applied Pharmacology, Faculty of Medicine, University of Sousse, Sousse 4002, TunisiaFaculty of Life and Environmental Sciences, University of Tsukuba, Tsukuba 305-8572, JapanAlliance for Research on the Mediterranean and North Africa (ARENA), University of Tsukuba, Tsukuba 305-8572, JapanEndocrinology-Diabetology Department, Farhat Hached Hospital, Sousse 4003, TunisiaDepartment of Biochemistry, Faulty of Medicine, University of Sousse, Sousse 4002, TunisiaFaculty of Life and Environmental Sciences, University of Tsukuba, Tsukuba 305-8572, JapanLaboratory of Metabolic Biophysics and Applied Pharmacology, Faculty of Medicine, University of Sousse, Sousse 4002, TunisiaIn the present study, we aimed to explore the feasibility, compliance, and potential benefits of <i>Nitraria retusa</i> extract (NRE) intervention in both healthy (BMI ≤ 24.9 Kg/m<sup>2</sup>) and overweight/obese adults (BMI > 25 Kg/m<sup>2</sup>). A total of 98 participants, including 37 healthy individuals and 61 overweight/obese adults, were randomly assigned to either a low-dose (500 mg/day) or a high-dose (2000 mg/day) NRE intervention group. Plasma lipid biomarkers, liver and kidney functions, general hematology, and blood glucose levels were measured at the baseline and 10 days after intervention. While the lipid profile of the healthy participants did not show any statistically significant changes, the obese participants in the high-dose group experienced a significant decrease in triglyceride levels (within-group difference <i>p</i> value = 0.004) and an increase in HDL levels (within-group <i>p</i> value < 0.001). No significant differences were observed in other parameters, indicating that NRE at the given doses was safe. Furthermore, the study had impressive compliance and acceptability, with over 90% of participants completing the intervention and diligently following the study protocol. This pilot study represents the first investigation into the feasibility, acceptability, and potential benefits of NRE intervention on lipid profiles in human volunteers.https://www.mdpi.com/2072-6643/15/16/3649<i>Nitraria retusa</i>HDLtriglycerideoverweightobesitydyslipidemia |
| spellingShingle | Aicha Laouani Hana Nasrallah Awatef Sassi Farhana Ferdousi Feten Zar Kalai Yosra Hasni Khalifa Limem Hiroko Isoda Saad Saguem Exploring the Effects of Short-Term Daily Intake of <i>Nitraria retusa</i> Tea on Lipid Profile: A Pre-Post, Uncontrolled Pilot Study in Both Healthy and Overweight/Obese Adults Nutrients <i>Nitraria retusa</i> HDL triglyceride overweight obesity dyslipidemia |
| title | Exploring the Effects of Short-Term Daily Intake of <i>Nitraria retusa</i> Tea on Lipid Profile: A Pre-Post, Uncontrolled Pilot Study in Both Healthy and Overweight/Obese Adults |
| title_full | Exploring the Effects of Short-Term Daily Intake of <i>Nitraria retusa</i> Tea on Lipid Profile: A Pre-Post, Uncontrolled Pilot Study in Both Healthy and Overweight/Obese Adults |
| title_fullStr | Exploring the Effects of Short-Term Daily Intake of <i>Nitraria retusa</i> Tea on Lipid Profile: A Pre-Post, Uncontrolled Pilot Study in Both Healthy and Overweight/Obese Adults |
| title_full_unstemmed | Exploring the Effects of Short-Term Daily Intake of <i>Nitraria retusa</i> Tea on Lipid Profile: A Pre-Post, Uncontrolled Pilot Study in Both Healthy and Overweight/Obese Adults |
| title_short | Exploring the Effects of Short-Term Daily Intake of <i>Nitraria retusa</i> Tea on Lipid Profile: A Pre-Post, Uncontrolled Pilot Study in Both Healthy and Overweight/Obese Adults |
| title_sort | exploring the effects of short term daily intake of i nitraria retusa i tea on lipid profile a pre post uncontrolled pilot study in both healthy and overweight obese adults |
| topic | <i>Nitraria retusa</i> HDL triglyceride overweight obesity dyslipidemia |
| url | https://www.mdpi.com/2072-6643/15/16/3649 |
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