Recovery and Visualization of 3D Structure of Chromosomes from Tomographic Reconstruction Images
<p/> <p>The objectives of this work include automatic recovery and visualization of a 3D chromosome structure from a sequence of 2D tomographic reconstruction images taken through the nucleus of a cell. Structure is very important for biologists as it affects chromosome functions, behavi...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2006-01-01
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| Series: | EURASIP Journal on Advances in Signal Processing |
| Online Access: | http://dx.doi.org/10.1155/ASP/2006/45684 |
| _version_ | 1817993747338625024 |
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| author | Tsap Leonid V Babu Sabarish Liao Pao-Chuan Shin Min C |
| author_facet | Tsap Leonid V Babu Sabarish Liao Pao-Chuan Shin Min C |
| author_sort | Tsap Leonid V |
| collection | DOAJ |
| description | <p/> <p>The objectives of this work include automatic recovery and visualization of a 3D chromosome structure from a sequence of 2D tomographic reconstruction images taken through the nucleus of a cell. Structure is very important for biologists as it affects chromosome functions, behavior of the cell, and its state. Analysis of chromosome structure is significant in the detection of diseases, identification of chromosomal abnormalities, study of DNA structural conformation, in-depth study of chromosomal surface morphology, observation of in vivo behavior of the chromosomes over time, and in monitoring environmental gene mutations. The methodology incorporates thresholding based on a histogram analysis with a polyline splitting algorithm, contour extraction via active contours, and detection of the 3D chromosome structure by establishing corresponding regions throughout the slices. Visualization using point cloud meshing generates a 3D surface. The 3D triangular mesh of the chromosomes provides surface detail and allows a user to interactively analyze chromosomes using visualization software.</p> |
| first_indexed | 2024-04-14T01:42:58Z |
| format | Article |
| id | doaj.art-40599b2cb11c4e0c99fd06f8c129ae43 |
| institution | Directory Open Access Journal |
| issn | 1687-6172 1687-6180 |
| language | English |
| last_indexed | 2024-04-14T01:42:58Z |
| publishDate | 2006-01-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | EURASIP Journal on Advances in Signal Processing |
| spelling | doaj.art-40599b2cb11c4e0c99fd06f8c129ae432022-12-22T02:19:38ZengSpringerOpenEURASIP Journal on Advances in Signal Processing1687-61721687-61802006-01-0120061045684Recovery and Visualization of 3D Structure of Chromosomes from Tomographic Reconstruction ImagesTsap Leonid VBabu SabarishLiao Pao-ChuanShin Min C<p/> <p>The objectives of this work include automatic recovery and visualization of a 3D chromosome structure from a sequence of 2D tomographic reconstruction images taken through the nucleus of a cell. Structure is very important for biologists as it affects chromosome functions, behavior of the cell, and its state. Analysis of chromosome structure is significant in the detection of diseases, identification of chromosomal abnormalities, study of DNA structural conformation, in-depth study of chromosomal surface morphology, observation of in vivo behavior of the chromosomes over time, and in monitoring environmental gene mutations. The methodology incorporates thresholding based on a histogram analysis with a polyline splitting algorithm, contour extraction via active contours, and detection of the 3D chromosome structure by establishing corresponding regions throughout the slices. Visualization using point cloud meshing generates a 3D surface. The 3D triangular mesh of the chromosomes provides surface detail and allows a user to interactively analyze chromosomes using visualization software.</p>http://dx.doi.org/10.1155/ASP/2006/45684 |
| spellingShingle | Tsap Leonid V Babu Sabarish Liao Pao-Chuan Shin Min C Recovery and Visualization of 3D Structure of Chromosomes from Tomographic Reconstruction Images EURASIP Journal on Advances in Signal Processing |
| title | Recovery and Visualization of 3D Structure of Chromosomes from Tomographic Reconstruction Images |
| title_full | Recovery and Visualization of 3D Structure of Chromosomes from Tomographic Reconstruction Images |
| title_fullStr | Recovery and Visualization of 3D Structure of Chromosomes from Tomographic Reconstruction Images |
| title_full_unstemmed | Recovery and Visualization of 3D Structure of Chromosomes from Tomographic Reconstruction Images |
| title_short | Recovery and Visualization of 3D Structure of Chromosomes from Tomographic Reconstruction Images |
| title_sort | recovery and visualization of 3d structure of chromosomes from tomographic reconstruction images |
| url | http://dx.doi.org/10.1155/ASP/2006/45684 |
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