Fate of the molar dental lamina in the monophyodont mouse.
The successional dental lamina (SDL) plays an essential role in the development of replacement teeth in diphyodont and polyphyodont animals. A morphologically similar structure, the rudimental successional dental lamina (RSDL), has been described in monophyodont (only one tooth generation) lizards o...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4444311?pdf=render |
| _version_ | 1817982804731887616 |
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| author | Hana Dosedělová Jana Dumková Hervé Lesot Kristýna Glocová Michaela Kunová Abigail S Tucker Iva Veselá Pavel Krejčí František Tichý Aleš Hampl Marcela Buchtová |
| author_facet | Hana Dosedělová Jana Dumková Hervé Lesot Kristýna Glocová Michaela Kunová Abigail S Tucker Iva Veselá Pavel Krejčí František Tichý Aleš Hampl Marcela Buchtová |
| author_sort | Hana Dosedělová |
| collection | DOAJ |
| description | The successional dental lamina (SDL) plays an essential role in the development of replacement teeth in diphyodont and polyphyodont animals. A morphologically similar structure, the rudimental successional dental lamina (RSDL), has been described in monophyodont (only one tooth generation) lizards on the lingual side of the developing functional tooth. This rudimentary lamina regresses, which has been proposed to play a role in preventing the formation of future generations of teeth. A similar rudimentary lingual structure has been reported associated with the first molar in the monophyodont mouse, and we show that this structure is common to all murine molars. Intriguingly, a lingual lamina is also observed on the non-replacing molars of other diphyodont mammals (pig and hedgehog), initially appearing very similar to the successional dental lamina on the replacing teeth. We have analyzed the morphological as well as ultrastructural changes that occur during the development and loss of this molar lamina in the mouse, from its initiation at late embryonic stages to its disappearance at postnatal stages. We show that loss appears to be driven by a reduction in cell proliferation, down-regulation of the progenitor marker Sox2, with only a small number of cells undergoing programmed cell death. The lingual lamina was associated with the dental stalk, a short epithelial connection between the tooth germ and the oral epithelium. The dental stalk remained in contact with the oral epithelium throughout tooth development up to eruption when connective tissue and numerous capillaries progressively invaded the dental stalk. The buccal side of the dental stalk underwent keratinisation and became part of the gingival epithelium, while most of the lingual cells underwent programmed cell death and the tissue directly above the erupting tooth was shed into the oral cavity. |
| first_indexed | 2024-04-13T23:25:02Z |
| format | Article |
| id | doaj.art-4059da165f884b958c46e129d1e8c126 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-13T23:25:02Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-4059da165f884b958c46e129d1e8c1262022-12-22T02:25:06ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01105e012754310.1371/journal.pone.0127543Fate of the molar dental lamina in the monophyodont mouse.Hana DosedělováJana DumkováHervé LesotKristýna GlocováMichaela KunováAbigail S TuckerIva VeseláPavel KrejčíFrantišek TichýAleš HamplMarcela BuchtováThe successional dental lamina (SDL) plays an essential role in the development of replacement teeth in diphyodont and polyphyodont animals. A morphologically similar structure, the rudimental successional dental lamina (RSDL), has been described in monophyodont (only one tooth generation) lizards on the lingual side of the developing functional tooth. This rudimentary lamina regresses, which has been proposed to play a role in preventing the formation of future generations of teeth. A similar rudimentary lingual structure has been reported associated with the first molar in the monophyodont mouse, and we show that this structure is common to all murine molars. Intriguingly, a lingual lamina is also observed on the non-replacing molars of other diphyodont mammals (pig and hedgehog), initially appearing very similar to the successional dental lamina on the replacing teeth. We have analyzed the morphological as well as ultrastructural changes that occur during the development and loss of this molar lamina in the mouse, from its initiation at late embryonic stages to its disappearance at postnatal stages. We show that loss appears to be driven by a reduction in cell proliferation, down-regulation of the progenitor marker Sox2, with only a small number of cells undergoing programmed cell death. The lingual lamina was associated with the dental stalk, a short epithelial connection between the tooth germ and the oral epithelium. The dental stalk remained in contact with the oral epithelium throughout tooth development up to eruption when connective tissue and numerous capillaries progressively invaded the dental stalk. The buccal side of the dental stalk underwent keratinisation and became part of the gingival epithelium, while most of the lingual cells underwent programmed cell death and the tissue directly above the erupting tooth was shed into the oral cavity.http://europepmc.org/articles/PMC4444311?pdf=render |
| spellingShingle | Hana Dosedělová Jana Dumková Hervé Lesot Kristýna Glocová Michaela Kunová Abigail S Tucker Iva Veselá Pavel Krejčí František Tichý Aleš Hampl Marcela Buchtová Fate of the molar dental lamina in the monophyodont mouse. PLoS ONE |
| title | Fate of the molar dental lamina in the monophyodont mouse. |
| title_full | Fate of the molar dental lamina in the monophyodont mouse. |
| title_fullStr | Fate of the molar dental lamina in the monophyodont mouse. |
| title_full_unstemmed | Fate of the molar dental lamina in the monophyodont mouse. |
| title_short | Fate of the molar dental lamina in the monophyodont mouse. |
| title_sort | fate of the molar dental lamina in the monophyodont mouse |
| url | http://europepmc.org/articles/PMC4444311?pdf=render |
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