Efficacy of a diarylheptanoid derivative against Leishmania amazonensis
The activity of several diarylheptanoid derivatives (curcuminoids) was previously evaluated against Leishmania amazonensis promastigotes and among them the most active compound was the [1-(4-methoxy-phenyl)-7-(3,4-methoxy-4-hydroxy-phenyl)-1,6-heptadien-3, 5-dione]. This derivative was chosen to be...
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Fundação Oswaldo Cruz (FIOCRUZ)
2003-01-01
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Series: | Memorias do Instituto Oswaldo Cruz |
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Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762003000400024 |
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author | Alves Luciana Vignólio Temporal Rosane Maria Cysne-Finkelstein Léa Leon Leonor Laura |
author_facet | Alves Luciana Vignólio Temporal Rosane Maria Cysne-Finkelstein Léa Leon Leonor Laura |
author_sort | Alves Luciana Vignólio |
collection | DOAJ |
description | The activity of several diarylheptanoid derivatives (curcuminoids) was previously evaluated against Leishmania amazonensis promastigotes and among them the most active compound was the [1-(4-methoxy-phenyl)-7-(3,4-methoxy-4-hydroxy-phenyl)-1,6-heptadien-3, 5-dione]. This derivative was chosen to be assayed in vivo in a treatment trial. For these experiments, the curcuminoid compound was used in a concentration equivalent to the IC50/24 h, obtained from the previous study. Balb/c mice were inoculated subcutaneously in the footpad with L. amazonensis infective promastigotes and 4 weeks after the inoculation, the animals were treated with different schemes, varying from 1 to 3 doses. In all the experiments, Pentamidine Isethionate was used as reference drug under the same experimental conditions. The results showed that one dose was not enough to heal the lesion, however, with 2 and 3 doses the efficiency of the assayed compound was clear. On the other hand, treatment with Pentamidine Isethionate using the three different schemes was not satisfactory when compared to the curcuminoid derivative. |
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issn | 0074-0276 1678-8060 |
language | English |
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spelling | doaj.art-405a35ba12bc4868bbc6bc9c4a271b3b2023-08-02T09:32:28ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80602003-01-01984553555Efficacy of a diarylheptanoid derivative against Leishmania amazonensisAlves Luciana VignólioTemporal Rosane MariaCysne-Finkelstein LéaLeon Leonor LauraThe activity of several diarylheptanoid derivatives (curcuminoids) was previously evaluated against Leishmania amazonensis promastigotes and among them the most active compound was the [1-(4-methoxy-phenyl)-7-(3,4-methoxy-4-hydroxy-phenyl)-1,6-heptadien-3, 5-dione]. This derivative was chosen to be assayed in vivo in a treatment trial. For these experiments, the curcuminoid compound was used in a concentration equivalent to the IC50/24 h, obtained from the previous study. Balb/c mice were inoculated subcutaneously in the footpad with L. amazonensis infective promastigotes and 4 weeks after the inoculation, the animals were treated with different schemes, varying from 1 to 3 doses. In all the experiments, Pentamidine Isethionate was used as reference drug under the same experimental conditions. The results showed that one dose was not enough to heal the lesion, however, with 2 and 3 doses the efficiency of the assayed compound was clear. On the other hand, treatment with Pentamidine Isethionate using the three different schemes was not satisfactory when compared to the curcuminoid derivative.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762003000400024diarylheptanoidtreatment trialLeishmania amazonensisleishmaniasis |
spellingShingle | Alves Luciana Vignólio Temporal Rosane Maria Cysne-Finkelstein Léa Leon Leonor Laura Efficacy of a diarylheptanoid derivative against Leishmania amazonensis Memorias do Instituto Oswaldo Cruz diarylheptanoid treatment trial Leishmania amazonensis leishmaniasis |
title | Efficacy of a diarylheptanoid derivative against Leishmania amazonensis |
title_full | Efficacy of a diarylheptanoid derivative against Leishmania amazonensis |
title_fullStr | Efficacy of a diarylheptanoid derivative against Leishmania amazonensis |
title_full_unstemmed | Efficacy of a diarylheptanoid derivative against Leishmania amazonensis |
title_short | Efficacy of a diarylheptanoid derivative against Leishmania amazonensis |
title_sort | efficacy of a diarylheptanoid derivative against leishmania amazonensis |
topic | diarylheptanoid treatment trial Leishmania amazonensis leishmaniasis |
url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762003000400024 |
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