Novel Diagnostic Methods for Infective Endocarditis
Infective endocarditis (IE) remains a dangerous disease and continues to have a high mortality rate. Unfortunately, despite continuous improvements in diagnostic methods, in many cases, blood cultures remain negative, and the pathogen causing endocarditis is unknown. This makes targeted therapy and...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/25/2/1245 |
| _version_ | 1797339737898352640 |
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| author | Anna Burban Dorota Słupik Aleksandra Reda Ewa Szczerba Marcin Grabowski Agnieszka Kołodzińska |
| author_facet | Anna Burban Dorota Słupik Aleksandra Reda Ewa Szczerba Marcin Grabowski Agnieszka Kołodzińska |
| author_sort | Anna Burban |
| collection | DOAJ |
| description | Infective endocarditis (IE) remains a dangerous disease and continues to have a high mortality rate. Unfortunately, despite continuous improvements in diagnostic methods, in many cases, blood cultures remain negative, and the pathogen causing endocarditis is unknown. This makes targeted therapy and the selection of appropriate antibiotics impossible. Therefore, we present what methods can be used to identify the pathogen in infective endocarditis. These are mainly molecular methods, including PCR and MGS, as well as imaging methods using radiotracers, which offer more possibilities for diagnosing IE. However, they are still not widely used in the diagnosis of IE. The article summarizes in which cases we should choose them and what we are most hopeful about in further research into the diagnosis of IE. In addition, registered clinical trials that are currently underway for the diagnosis of IE are also presented. |
| first_indexed | 2024-03-08T09:52:42Z |
| format | Article |
| id | doaj.art-405d700d3e2d4b528311c79296522500 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-08T09:52:42Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-405d700d3e2d4b528311c792965225002024-01-29T13:58:47ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672024-01-01252124510.3390/ijms25021245Novel Diagnostic Methods for Infective EndocarditisAnna Burban0Dorota Słupik1Aleksandra Reda2Ewa Szczerba3Marcin Grabowski4Agnieszka Kołodzińska51st Chair and Department of Cardiology, Medical University of Warsaw, 02-097 Warsaw, Poland1st Chair and Department of Cardiology, Medical University of Warsaw, 02-097 Warsaw, Poland1st Chair and Department of Cardiology, Medical University of Warsaw, 02-097 Warsaw, Poland1st Chair and Department of Cardiology, Medical University of Warsaw, 02-097 Warsaw, Poland1st Chair and Department of Cardiology, Medical University of Warsaw, 02-097 Warsaw, Poland1st Chair and Department of Cardiology, Medical University of Warsaw, 02-097 Warsaw, PolandInfective endocarditis (IE) remains a dangerous disease and continues to have a high mortality rate. Unfortunately, despite continuous improvements in diagnostic methods, in many cases, blood cultures remain negative, and the pathogen causing endocarditis is unknown. This makes targeted therapy and the selection of appropriate antibiotics impossible. Therefore, we present what methods can be used to identify the pathogen in infective endocarditis. These are mainly molecular methods, including PCR and MGS, as well as imaging methods using radiotracers, which offer more possibilities for diagnosing IE. However, they are still not widely used in the diagnosis of IE. The article summarizes in which cases we should choose them and what we are most hopeful about in further research into the diagnosis of IE. In addition, registered clinical trials that are currently underway for the diagnosis of IE are also presented.https://www.mdpi.com/1422-0067/25/2/1245infective endocarditisPET/CT tracers16S/18S rRNA PCRmolecular diagnosis |
| spellingShingle | Anna Burban Dorota Słupik Aleksandra Reda Ewa Szczerba Marcin Grabowski Agnieszka Kołodzińska Novel Diagnostic Methods for Infective Endocarditis International Journal of Molecular Sciences infective endocarditis PET/CT tracers 16S/18S rRNA PCR molecular diagnosis |
| title | Novel Diagnostic Methods for Infective Endocarditis |
| title_full | Novel Diagnostic Methods for Infective Endocarditis |
| title_fullStr | Novel Diagnostic Methods for Infective Endocarditis |
| title_full_unstemmed | Novel Diagnostic Methods for Infective Endocarditis |
| title_short | Novel Diagnostic Methods for Infective Endocarditis |
| title_sort | novel diagnostic methods for infective endocarditis |
| topic | infective endocarditis PET/CT tracers 16S/18S rRNA PCR molecular diagnosis |
| url | https://www.mdpi.com/1422-0067/25/2/1245 |
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