Successful discontinuation of immunoglobulin G replacement at age 10 in a patient with immunoglobulin G2 deficiency
Context: Immunoglobulin G2 deficiency that persists beyond the age of 6 years is likely to be permanent. Case report: We report on a young Japanese female, diagnosed as having immunoglobulin G2 deficiency and low anti-pneumococcal immunoglobulin G2 antibody levels when 3 years old, with a subsequent...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2017-10-01
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| Series: | SAGE Open Medical Case Reports |
| Online Access: | https://doi.org/10.1177/2050313X17736421 |
| _version_ | 1818279970863054848 |
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| author | Masayoshi Shinjoh Yukio Sakiyama Shinichiro Sekiguchi Takao Takahashi |
| author_facet | Masayoshi Shinjoh Yukio Sakiyama Shinichiro Sekiguchi Takao Takahashi |
| author_sort | Masayoshi Shinjoh |
| collection | DOAJ |
| description | Context: Immunoglobulin G2 deficiency that persists beyond the age of 6 years is likely to be permanent. Case report: We report on a young Japanese female, diagnosed as having immunoglobulin G2 deficiency and low anti-pneumococcal immunoglobulin G2 antibody levels when 3 years old, with a subsequent medical history of frequent respiratory infections and asthma. Monthly intravenous immunoglobulin replacement therapy was started at 4 years of age. After 8 years of age, an anti-pneumococcal immunoglobulin G2 trough level could be maintained with administration intervals longer than 6 weeks, and after 9 years and 10 months of age, therapy was discontinued. The frequency of hospital admissions was reduced by the introduction of the replacement therapy (from 8.4 times/year before the introduction to 1.1 times/year during the therapy). The patient was also able to discontinue daily medications for asthma, and serum immunoglobulin G2 was maintained at a normal level even after the cessation of replacement therapy. Conclusion: Termination of immunoglobulin replacement therapy in a patient with a symptomatic immunoglobulin G2 deficiency is possible, even for a child older than 6 years. |
| first_indexed | 2024-12-12T23:41:48Z |
| format | Article |
| id | doaj.art-4061b7c50fe94068baca02234bd0b5a8 |
| institution | Directory Open Access Journal |
| issn | 2050-313X |
| language | English |
| last_indexed | 2024-12-12T23:41:48Z |
| publishDate | 2017-10-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | SAGE Open Medical Case Reports |
| spelling | doaj.art-4061b7c50fe94068baca02234bd0b5a82022-12-22T00:07:05ZengSAGE PublishingSAGE Open Medical Case Reports2050-313X2017-10-01510.1177/2050313X17736421Successful discontinuation of immunoglobulin G replacement at age 10 in a patient with immunoglobulin G2 deficiencyMasayoshi Shinjoh0Yukio Sakiyama1Shinichiro Sekiguchi2Takao Takahashi3Department of Pediatrics, Keio University School of Medicine, Tokyo, JapanDepartment of Pediatrics, Youtei Clinic, Kutchan, JapanDepartment of Pediatrics, Keio University School of Medicine, Tokyo, JapanDepartment of Pediatrics, Keio University School of Medicine, Tokyo, JapanContext: Immunoglobulin G2 deficiency that persists beyond the age of 6 years is likely to be permanent. Case report: We report on a young Japanese female, diagnosed as having immunoglobulin G2 deficiency and low anti-pneumococcal immunoglobulin G2 antibody levels when 3 years old, with a subsequent medical history of frequent respiratory infections and asthma. Monthly intravenous immunoglobulin replacement therapy was started at 4 years of age. After 8 years of age, an anti-pneumococcal immunoglobulin G2 trough level could be maintained with administration intervals longer than 6 weeks, and after 9 years and 10 months of age, therapy was discontinued. The frequency of hospital admissions was reduced by the introduction of the replacement therapy (from 8.4 times/year before the introduction to 1.1 times/year during the therapy). The patient was also able to discontinue daily medications for asthma, and serum immunoglobulin G2 was maintained at a normal level even after the cessation of replacement therapy. Conclusion: Termination of immunoglobulin replacement therapy in a patient with a symptomatic immunoglobulin G2 deficiency is possible, even for a child older than 6 years.https://doi.org/10.1177/2050313X17736421 |
| spellingShingle | Masayoshi Shinjoh Yukio Sakiyama Shinichiro Sekiguchi Takao Takahashi Successful discontinuation of immunoglobulin G replacement at age 10 in a patient with immunoglobulin G2 deficiency SAGE Open Medical Case Reports |
| title | Successful discontinuation of immunoglobulin G replacement at age 10 in a patient with immunoglobulin G2 deficiency |
| title_full | Successful discontinuation of immunoglobulin G replacement at age 10 in a patient with immunoglobulin G2 deficiency |
| title_fullStr | Successful discontinuation of immunoglobulin G replacement at age 10 in a patient with immunoglobulin G2 deficiency |
| title_full_unstemmed | Successful discontinuation of immunoglobulin G replacement at age 10 in a patient with immunoglobulin G2 deficiency |
| title_short | Successful discontinuation of immunoglobulin G replacement at age 10 in a patient with immunoglobulin G2 deficiency |
| title_sort | successful discontinuation of immunoglobulin g replacement at age 10 in a patient with immunoglobulin g2 deficiency |
| url | https://doi.org/10.1177/2050313X17736421 |
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