Transperineal ultrasonography for treatment response evaluation in children with perianal Crohn’s disease
Purpose This study assessed the performance of transperineal ultrasonography (TPUS) in evaluating the treatment response in children with perianal Crohn’s disease (PACD) compared with pelvic magnetic resonance imaging (MRI). Methods This retrospective study was approved by the Institutional Review B...
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| Format: | Article |
| Language: | English |
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Korean Society of Ultrasound in Medicine
2022-10-01
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| Series: | Ultrasonography |
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| Online Access: | http://www.e-ultrasonography.org/upload/usg-22057.pdf |
| _version_ | 1811243119432171520 |
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| author | Jae Hyeop Jung Young Jin Ryu Ji Young Kim Hye Ran Yang |
| author_facet | Jae Hyeop Jung Young Jin Ryu Ji Young Kim Hye Ran Yang |
| author_sort | Jae Hyeop Jung |
| collection | DOAJ |
| description | Purpose This study assessed the performance of transperineal ultrasonography (TPUS) in evaluating the treatment response in children with perianal Crohn’s disease (PACD) compared with pelvic magnetic resonance imaging (MRI). Methods This retrospective study was approved by the Institutional Review Board of our institution, which waived the requirement for informed consent. Twenty-nine patients (19 boys and 10 girls; median age, 14 years [range, 8 to 18 years]) with 56 fistulas were examined. Each fistula’s thickness and abscess size were measured using both modalities, and treatment response was classified as positive or negative based on each modality. The concordance of the classifications was compared between TPUS and pelvic MRI. A receiver operating characteristic curve (ROC) was used to evaluate the performance of TPUS. Results TPUS found 80.4% (45/56) of the fistulas. On MRI, 39 fistulas (70%) were classified as having positive treatment responses, and the remaining 17 as having no response. The agreement of the classifications between TPUS and MRI was moderate (κ=0.486; P<0.001; Spearman ρ=0.573; P<0.001). Based on the ROC analysis with the MRI findings as a reference to distinguish positive from negative treatment responses, TPUS exhibited sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of 63.3%, 93.3%, 95.0%, 56.0%, and 73.3%, respectively. Conclusion TPUS can be an appropriate adjuvant imaging modality for pelvic MRI to evaluate the treatment response of PACD in children when initial TPUS detects PACD with a location and imaging features comparable to those visualized on MRI. |
| first_indexed | 2024-04-12T14:02:00Z |
| format | Article |
| id | doaj.art-40626690ac014a169d3502da7b4a5370 |
| institution | Directory Open Access Journal |
| issn | 2288-5919 2288-5943 |
| language | English |
| last_indexed | 2024-04-12T14:02:00Z |
| publishDate | 2022-10-01 |
| publisher | Korean Society of Ultrasound in Medicine |
| record_format | Article |
| series | Ultrasonography |
| spelling | doaj.art-40626690ac014a169d3502da7b4a53702022-12-22T03:30:10ZengKorean Society of Ultrasound in MedicineUltrasonography2288-59192288-59432022-10-0141477078110.14366/usg.220571628Transperineal ultrasonography for treatment response evaluation in children with perianal Crohn’s diseaseJae Hyeop Jung0Young Jin Ryu1Ji Young Kim2Hye Ran Yang3 Department of Radiology, Seoul National University Bundang Hospital, Seongnam, Korea Department of Radiology, Seoul National University Bundang Hospital, Seongnam, Korea Department of Radiology, Seoul National University Bundang Hospital, Seongnam, Korea Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam, KoreaPurpose This study assessed the performance of transperineal ultrasonography (TPUS) in evaluating the treatment response in children with perianal Crohn’s disease (PACD) compared with pelvic magnetic resonance imaging (MRI). Methods This retrospective study was approved by the Institutional Review Board of our institution, which waived the requirement for informed consent. Twenty-nine patients (19 boys and 10 girls; median age, 14 years [range, 8 to 18 years]) with 56 fistulas were examined. Each fistula’s thickness and abscess size were measured using both modalities, and treatment response was classified as positive or negative based on each modality. The concordance of the classifications was compared between TPUS and pelvic MRI. A receiver operating characteristic curve (ROC) was used to evaluate the performance of TPUS. Results TPUS found 80.4% (45/56) of the fistulas. On MRI, 39 fistulas (70%) were classified as having positive treatment responses, and the remaining 17 as having no response. The agreement of the classifications between TPUS and MRI was moderate (κ=0.486; P<0.001; Spearman ρ=0.573; P<0.001). Based on the ROC analysis with the MRI findings as a reference to distinguish positive from negative treatment responses, TPUS exhibited sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of 63.3%, 93.3%, 95.0%, 56.0%, and 73.3%, respectively. Conclusion TPUS can be an appropriate adjuvant imaging modality for pelvic MRI to evaluate the treatment response of PACD in children when initial TPUS detects PACD with a location and imaging features comparable to those visualized on MRI.http://www.e-ultrasonography.org/upload/usg-22057.pdfultrasonographyfistulaabscessanal canal |
| spellingShingle | Jae Hyeop Jung Young Jin Ryu Ji Young Kim Hye Ran Yang Transperineal ultrasonography for treatment response evaluation in children with perianal Crohn’s disease Ultrasonography ultrasonography fistula abscess anal canal |
| title | Transperineal ultrasonography for treatment response evaluation in children with perianal Crohn’s disease |
| title_full | Transperineal ultrasonography for treatment response evaluation in children with perianal Crohn’s disease |
| title_fullStr | Transperineal ultrasonography for treatment response evaluation in children with perianal Crohn’s disease |
| title_full_unstemmed | Transperineal ultrasonography for treatment response evaluation in children with perianal Crohn’s disease |
| title_short | Transperineal ultrasonography for treatment response evaluation in children with perianal Crohn’s disease |
| title_sort | transperineal ultrasonography for treatment response evaluation in children with perianal crohn s disease |
| topic | ultrasonography fistula abscess anal canal |
| url | http://www.e-ultrasonography.org/upload/usg-22057.pdf |
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