Increased structural connectivity in high schizotypy
AbstractThe link between brain structural connectivity and schizotypy was explored in two healthy participant cohorts, collected at two different neuroimaging centres, comprising 140 and 115 participants, respectively. The participants completed the Schizotypal Personality Questionna...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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The MIT Press
2023-01-01
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| Series: | Network Neuroscience |
| Online Access: | https://direct.mit.edu/netn/article/7/1/213/113095/Increased-structural-connectivity-in-high |
| _version_ | 1797838294108602368 |
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| author | Eirini Messaritaki Sonya Foley Kali Barawi Ulrich Ettinger Derek K. Jones |
| author_facet | Eirini Messaritaki Sonya Foley Kali Barawi Ulrich Ettinger Derek K. Jones |
| author_sort | Eirini Messaritaki |
| collection | DOAJ |
| description |
AbstractThe link between brain structural connectivity and schizotypy was explored in two healthy participant cohorts, collected at two different neuroimaging centres, comprising 140 and 115 participants, respectively. The participants completed the Schizotypal Personality Questionnaire (SPQ), through which their schizotypy scores were calculated. Diffusion-MRI data were used to perform tractography and to generate the structural brain networks of the participants. The edges of the networks were weighted with the inverse radial diffusivity. Graph theoretical metrics of the default mode, sensorimotor, visual, and auditory subnetworks were derived and their correlation coefficients with the schizotypy scores were calculated. To the best of our knowledge, this is the first time that graph theoretical measures of structural brain networks are investigated in relation to schizotypy. A positive correlation was found between the schizotypy score and the mean node degree and mean clustering coefficient of the sensorimotor and the default mode subnetworks. The nodes driving these correlations were the right postcentral gyrus, the left paracentral lobule, the right superior frontal gyrus, the left parahippocampal gyrus, and the bilateral precuneus, that is, nodes that exhibit compromised functional connectivity in schizophrenia. Implications for schizophrenia and schizotypy are discussed. |
| first_indexed | 2024-04-09T15:39:38Z |
| format | Article |
| id | doaj.art-4064b25428f74d4b9c03c9d56558b895 |
| institution | Directory Open Access Journal |
| issn | 2472-1751 |
| language | English |
| last_indexed | 2024-04-09T15:39:38Z |
| publishDate | 2023-01-01 |
| publisher | The MIT Press |
| record_format | Article |
| series | Network Neuroscience |
| spelling | doaj.art-4064b25428f74d4b9c03c9d56558b8952023-04-27T13:11:14ZengThe MIT PressNetwork Neuroscience2472-17512023-01-017121323310.1162/netn_a_00279Increased structural connectivity in high schizotypyEirini Messaritaki0http://orcid.org/0000-0002-9917-4160Sonya Foley1http://orcid.org/0000-0002-8390-2709Kali Barawi2Ulrich Ettinger3http://orcid.org/0000-0002-0160-0281Derek K. Jones4http://orcid.org/0000-0003-4409-8049Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, UKCardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, UKSchool of Medicine, Cardiff University, Cardiff, UKDepartment of Psychology, University of Bonn, Bonn, GermanyCardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, UK AbstractThe link between brain structural connectivity and schizotypy was explored in two healthy participant cohorts, collected at two different neuroimaging centres, comprising 140 and 115 participants, respectively. The participants completed the Schizotypal Personality Questionnaire (SPQ), through which their schizotypy scores were calculated. Diffusion-MRI data were used to perform tractography and to generate the structural brain networks of the participants. The edges of the networks were weighted with the inverse radial diffusivity. Graph theoretical metrics of the default mode, sensorimotor, visual, and auditory subnetworks were derived and their correlation coefficients with the schizotypy scores were calculated. To the best of our knowledge, this is the first time that graph theoretical measures of structural brain networks are investigated in relation to schizotypy. A positive correlation was found between the schizotypy score and the mean node degree and mean clustering coefficient of the sensorimotor and the default mode subnetworks. The nodes driving these correlations were the right postcentral gyrus, the left paracentral lobule, the right superior frontal gyrus, the left parahippocampal gyrus, and the bilateral precuneus, that is, nodes that exhibit compromised functional connectivity in schizophrenia. Implications for schizophrenia and schizotypy are discussed.https://direct.mit.edu/netn/article/7/1/213/113095/Increased-structural-connectivity-in-high |
| spellingShingle | Eirini Messaritaki Sonya Foley Kali Barawi Ulrich Ettinger Derek K. Jones Increased structural connectivity in high schizotypy Network Neuroscience |
| title | Increased structural connectivity in high schizotypy |
| title_full | Increased structural connectivity in high schizotypy |
| title_fullStr | Increased structural connectivity in high schizotypy |
| title_full_unstemmed | Increased structural connectivity in high schizotypy |
| title_short | Increased structural connectivity in high schizotypy |
| title_sort | increased structural connectivity in high schizotypy |
| url | https://direct.mit.edu/netn/article/7/1/213/113095/Increased-structural-connectivity-in-high |
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