CD19 chimeric antigen receptor T-cell therapy following autologous stem cell transplantation against relapsed or refractory Burkitt lymphoma/leukemia: A case report and literature review
Burkitt lymphoma or leukemia (BL) is a highly aggressive non-Hodgkin lymphoma. Older age (over 60 years old) and the presence of high-risk factors (such as abdominal mass, high levels of the serum lactic dehydrogenase, Ann Arbor stage II-IV and so on) usually predict a poorer outcome. Chimeric antig...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.932254/full |
| _version_ | 1817977995072110592 |
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| author | Mingyu Ye Lei Gao Tao Wang Jiechen Yu Jiaping Gui Jianmin Yang |
| author_facet | Mingyu Ye Lei Gao Tao Wang Jiechen Yu Jiaping Gui Jianmin Yang |
| author_sort | Mingyu Ye |
| collection | DOAJ |
| description | Burkitt lymphoma or leukemia (BL) is a highly aggressive non-Hodgkin lymphoma. Older age (over 60 years old) and the presence of high-risk factors (such as abdominal mass, high levels of the serum lactic dehydrogenase, Ann Arbor stage II-IV and so on) usually predict a poorer outcome. Chimeric antigen receptor T cells (CART) have achieved remarkable success in the treatment of B-cell leukemia and lymphoma. Here, for the first time, we report a 61-year-old, high-risk BL patient with autologous stem cell transplantation (ASCT) bridging therapy prior to CART as consolidation therapy. Our findings demonstrate that the combination of ASCT and CART for BL is safe and feasible. |
| first_indexed | 2024-04-13T22:23:39Z |
| format | Article |
| id | doaj.art-4064e0edcfbb4967a425f09cd6256d30 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-13T22:23:39Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-4064e0edcfbb4967a425f09cd6256d302022-12-22T02:27:07ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-10-011210.3389/fonc.2022.932254932254CD19 chimeric antigen receptor T-cell therapy following autologous stem cell transplantation against relapsed or refractory Burkitt lymphoma/leukemia: A case report and literature reviewMingyu YeLei GaoTao WangJiechen YuJiaping GuiJianmin YangBurkitt lymphoma or leukemia (BL) is a highly aggressive non-Hodgkin lymphoma. Older age (over 60 years old) and the presence of high-risk factors (such as abdominal mass, high levels of the serum lactic dehydrogenase, Ann Arbor stage II-IV and so on) usually predict a poorer outcome. Chimeric antigen receptor T cells (CART) have achieved remarkable success in the treatment of B-cell leukemia and lymphoma. Here, for the first time, we report a 61-year-old, high-risk BL patient with autologous stem cell transplantation (ASCT) bridging therapy prior to CART as consolidation therapy. Our findings demonstrate that the combination of ASCT and CART for BL is safe and feasible.https://www.frontiersin.org/articles/10.3389/fonc.2022.932254/fullBurkitt lymphomaleukemiaCD19chimeric antigen receptor T-cellautologous stem cell transplantation |
| spellingShingle | Mingyu Ye Lei Gao Tao Wang Jiechen Yu Jiaping Gui Jianmin Yang CD19 chimeric antigen receptor T-cell therapy following autologous stem cell transplantation against relapsed or refractory Burkitt lymphoma/leukemia: A case report and literature review Frontiers in Oncology Burkitt lymphoma leukemia CD19 chimeric antigen receptor T-cell autologous stem cell transplantation |
| title | CD19 chimeric antigen receptor T-cell therapy following autologous stem cell transplantation against relapsed or refractory Burkitt lymphoma/leukemia: A case report and literature review |
| title_full | CD19 chimeric antigen receptor T-cell therapy following autologous stem cell transplantation against relapsed or refractory Burkitt lymphoma/leukemia: A case report and literature review |
| title_fullStr | CD19 chimeric antigen receptor T-cell therapy following autologous stem cell transplantation against relapsed or refractory Burkitt lymphoma/leukemia: A case report and literature review |
| title_full_unstemmed | CD19 chimeric antigen receptor T-cell therapy following autologous stem cell transplantation against relapsed or refractory Burkitt lymphoma/leukemia: A case report and literature review |
| title_short | CD19 chimeric antigen receptor T-cell therapy following autologous stem cell transplantation against relapsed or refractory Burkitt lymphoma/leukemia: A case report and literature review |
| title_sort | cd19 chimeric antigen receptor t cell therapy following autologous stem cell transplantation against relapsed or refractory burkitt lymphoma leukemia a case report and literature review |
| topic | Burkitt lymphoma leukemia CD19 chimeric antigen receptor T-cell autologous stem cell transplantation |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.932254/full |
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